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ChemicalBook >> CAS DataBase List >>N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Structure
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine structure
CAS No.
381168-77-0
Chemical Name:
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Synonyms
ML367;ML367 ，S0161;ML367, 10 mM in DMSO;ML-367,ML367,inhibit,ML 367,Inhibitor;N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine;4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
CBNumber:
CB04248334
Molecular Formula:
C19H12F2N4
Molecular Weight:
334.32
MDL Number:
MOL File:
381168-77-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
ML367 GQA16877 10mg $896.6
ML367 GQA16877 25mg $1462
ML367 GQA16877 50mg $2339
ML367 99.84% CS-0082590 5mg $54
ML367 99.84% CS-0082590 10mg $87
Request For Quotation

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Properties

storage temp. Store at -20°C
solubility DMSO: ≥ 125 mg/mL (373.89 mM)
form Solid
color Light yellow to yellow

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth GQA16877 ML367 381168-77-0 10mg $896.6 2026-06-04 Buy
Biosynth GQA16877 ML367 381168-77-0 25mg $1462 2026-06-04 Buy
Biosynth GQA16877 ML367 381168-77-0 50mg $2339 2026-06-04 Buy
ChemScene CS-0082590 ML367 99.84% 381168-77-0 5mg $54 2026-06-04 Buy
ChemScene CS-0082590 ML367 99.84% 381168-77-0 10mg $87 2026-06-04 Buy
Product number Packaging Price Buy
GQA16877 10mg $896.6 Buy
GQA16877 25mg $1462 Buy
GQA16877 50mg $2339 Buy
CS-0082590 5mg $54 Buy
CS-0082590 10mg $87 Buy

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties,Uses,Production

Uses

ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1].

Biological Activity

ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.

in vitro

ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

Western Blot Analysis

< table class="zh_use_1"> Cell Line: HEK293T cells Concentration: 0-40 μM in the presence or absence of 20 μM 5-Furd Incubation Time: 16 hours Result: Inhibited the increased ATAD5 protein levels induced by 5-Furd.

target

References

[1] Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program. PMID:24479200

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Suppliers

Global( 38)Suppliers
TargetValue
ATAD5
()
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32998 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
Aladdin Scientific 		tp@aladdinsci.com United States 57473 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4860 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 13636370518 shyysw007@163.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 7997 62
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
BOC Sciences 65
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62

View Lastest Price from N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ML367 pictures 2026-07-27 ML367
381168-77-0
 $40.00-129.00 99.39% 10g TargetMol Chemicals Inc.
  • ML367 pictures
  • ML367
    381168-77-0
  • $40.00-129.00
  • 99.39%
  • TargetMol Chemicals Inc.

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Spectrum

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine(381168-77-0)1HNMR

381168-77-0(N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine)Related Search:

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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML367 4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)- ML-367,ML367,inhibit,ML 367,Inhibitor ML367, 10 mM in DMSO ML367 ，S0161 381168-77-0 C19H12F2N4