Neocuproine
- CAS No.
- 484-11-7
- Chemical Name:
- Neocuproine
- Synonyms
- 2,9-DIMETHYL-1,10-PHENANTHROLINE;DMPHEN;Mephen;2,9-Dimethylphenanthroline;2,9-dimethyl-10-phenanthroline;2,9-Dimethyl-o-phenanthroline;VUF 7738;NEOCUPROINE;Cuproin,neo;Neo-Cuproin
- CBNumber:
- CB0429520
- Molecular Formula:
- C14H12N2
- Molecular Weight:
- 208.26
- MDL Number:
- MFCD00004973
- MOL File:
- 484-11-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 159-164 °C |
|---|---|
| Boiling point | 337.46°C (rough estimate) |
| Density | 1.1345 (rough estimate) |
| bulk density | 280kg/m3 |
| refractive index | 1.6152 (estimate) |
| RTECS | SF8380000 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear |
| form | crystalline |
| pka | 6.01±0.30(Predicted) |
| color | white to beige |
| Water Solubility | slightly soluble |
| Sensitive | Light Sensitive |
| Merck | 6449 |
| InChI | 1S/C14H12N2/c1-9-3-5-11-7-8-12-6-4-10(2)16-14(12)13(11)15-9/h3-8H,1-2H3 |
| InChIKey | IYRGXJIJGHOCFS-UHFFFAOYSA-N |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1 |
| CAS DataBase Reference | 484-11-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 8E7D2SH3BV |
| NIST Chemistry Reference | 1,10-Phenanthroline, 2,9-dimethyl-(484-11-7) |
| EPA Substance Registry System | 1,10-Phenanthroline, 2,9-dimethyl- (484-11-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22-22 | |||||||||
| Safety Statements | 26-36/37/39-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Neocuproine price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N1501 | Neocuproine ≥98% | 484-11-7 | 1g | $39.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | N1501 | Neocuproine ≥98% | 484-11-7 | 5g | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1.02968 | Neocuproine GR for analysis | 484-11-7 | 5G | $260 | 2026-04-30 | Buy |
| Cayman Chemical | 20874 | Neocuproine ≥98% | 484-11-7 | 5g | $60 | 2026-04-30 | Buy |
| Cayman Chemical | 20874 | Neocuproine ≥98% | 484-11-7 | 10g | $104 | 2026-04-30 | Buy |
Neocuproine Chemical Properties, Uses, Production
Chemical Properties
Neocuproine is a off-white to very pale yellow crystalline powder, in the presence of reducing agents it reacts with copper to give a copper(I) complex of composition MA2 and of tetrahedral symmetry.
Uses
Due to the steric hindrance of the methyl groups attached to the carbon atoms
adjacent to the nitrogen donor atoms of phenanthroline, the reagent does not
give the low spin vivid red complex characteristic of phenanthroline derivatives
with iron(II). However, in the presence of reducing agents it reacts with copper to
give a copper(I) complex of composition MA2 and of tetrahedral symmetry. This
chelate is insoluble in water and can be extracted by chloroform in which the absorption
maximum of the complex appears at 457 nm. In this way the concentration
of the complex can be measured. The method is suitable for the determination
of copper in iron, manganese and vanadium ores even in the presence of
aluminium, germanium, titanium and silicon.
Neocuproine is today considered one of the most selective reagents. Unfortunately,
it is rather expensive. 2,3-bis-(2-pyridyl)quinoxaline, prepared by Belcher
et al. by condensation of o-diketone, 2,2'-dipyridyl and 0-phenylenediamine(44)
contains the functional grouping characteristic of cuproine; it is quite suitable for
the determination of copper and it is cheap. Starting with various substituted
o-phenylene-diamines Belcher synthesized 25 different quinoxaline derivatives,
of which 2,3-bis-[2-(-methyl)-pyridyl)]quinoxaline proved to be identical with
neocuproine as regards analytical selectivity. Besides copper, titanium(III) is the
only metal ion which gives a colour reaction with the reagent. However, the
coloured titanium(III) complex is formed only at lower pH and hence it does not
interfere with the determination of copper. The copper complex of the reagent can
be extracted quantitatively with isopentyl alcohol usually as a perchlorate ion pair.
Uses
Neocuproine is a phenanthroline based metal ion chelating agent.
Definition
ChEBI: A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two methyl substituents at positions 2 and 9.
Purification Methods
Purifiy it as the hemihydrate by crystallisation from water and as the anhydrous base from *benzene. [Beilstein 23/8 V 527.]
Neocuproine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong puyue biomedical Co., Ltd | 0513-0513-0513-89158300 18014392889 | sales@puyerbiopharma.com | China | 4956 | 58 |
| Zhengzhou AnMusi Chemical Products Co., Ltd. | 15981811963 18737195735 | 2370407954@qq.com | China | 1979 | 55 |
| Linyi Azelasi Biological Co., Ltd. | 17753923223; | 2805221329@qq.com | China | 1472 | 58 |
| Shandong Kangsaide Biological Technology Co. LTD | 18615616891 | zhangdong.0602@163.com | China | 145 | 58 |
| Hebei Kainuo New Material Technology Co., Ltd | 15932779957 or 18131036894 15932779957 | 204788595@qq.com | China | 36 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
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- Neocuproine acts as a specific Cu(I) chelator, widely used in copper detection, biochemical research, nanozyme sensing and pha....
- May 20,2026
View Latest Price from Neocuproine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-21 | 2,9-Dimethyl-1,10-phenanthroline
484-11-7
|
$12.00-104.00 | 1g | 0.98 | 10kg | Shanghai UCHEM Inc. | |
 |
2026-10-21 | Neocuproine
484-11-7
|
10g | 99% | 1 KG | Shanghai Massive Chemical Technology Co., Ltd | ||
 |
2026-07-22 | Neocuproine
484-11-7
|
1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd |
-
- 2,9-Dimethyl-1,10-phenanthroline
484-11-7
- $12.00-104.00
- 0.98
- Shanghai UCHEM Inc.
-
- Neocuproine
484-11-7
- 99%
- Shanghai Massive Chemical Technology Co., Ltd
-
- Neocuproine
484-11-7
- $0.00
- 99%
- Watson Biotechnology Co.,Ltd
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