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4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER structure

CAS No.: 132710-90-8

Chemical Name:: 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Synonyms: 1-Boc-4-(3-hydroxypropyl)piperazine,97%;tert-Butyl 4-(2-hydroxypropyl)piperazine-1-carboxylate;tert-Butyl 4-(3-hydroxy-propyl)-1-piperazinecarboxylate;1-Boc-4-(3-hydroxypropyl)piperazine;1,1-Dimethylethyl 4-(3-hydroxypropyl)-1-piperazinecarboxylate;4-(2-HYDROXYPROPYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER;1-Piperazinecarboxylic acid, 4-(3-hydroxypropyl)-, 1,1-dimethylethyl ester

CBNumber:: CB0430292

Molecular Formula:: C12H24N2O3

Molecular Weight:: 244.33

MDL Number:: MFCD06657040

MOL File:: 132710-90-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:39:05

Product description	Number	Pack Size	Price
1-Boc-4-(3-hydroxypropyl)piperazine 97%	643467	5g	$82.4
1-Boc-4-(3-hydroxypropyl)piperazine 97%	643467	25g	$313
1-Boc-4-(3-hydroxypropyl)piperazine	HFA71090	10g	$354
1-Boc-4-(3-hydroxypropyl)piperazine 99%	OR921732	1g	$21
1-Boc-4-(3-hydroxypropyl)piperazine 99%	OR921732	5g	$39

Request For Quotation

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Properties

Melting point	73-77 °C (lit.)
Boiling point	355.8±37.0 °C(Predicted)
Density	1.074±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	15.10±0.10(Predicted)
form	Solid
Appearance	White to off-white Solid
InChI	1S/C12H24N2O3/c1-12(2,3)17-11(16)14-8-6-13(7-9-14)5-4-10-15/h15H,4-10H2,1-3H3
InChIKey	LRYRQGKGCIUVON-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCN(CCCO)CC1
CAS DataBase Reference	132710-90-8
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P301+P310+P330-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

25-36/37/38

Safety Statements

26-36/37/39-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

HazardClass

6.1

HS Code

2924297099

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
3		0

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	643467	1-Boc-4-(3-hydroxypropyl)piperazine 97%	132710-90-8	5g	$82.4	2026-04-30	Buy
Sigma-Aldrich	643467	1-Boc-4-(3-hydroxypropyl)piperazine 97%	132710-90-8	25g	$313	2026-04-30	Buy
Biosynth	HFA71090	1-Boc-4-(3-hydroxypropyl)piperazine	132710-90-8	10g	$354	2026-06-04	Buy
Apolloscientific	OR921732	1-Boc-4-(3-hydroxypropyl)piperazine 99%	132710-90-8	1g	$21	2026-06-04	Buy
Apolloscientific	OR921732	1-Boc-4-(3-hydroxypropyl)piperazine 99%	132710-90-8	5g	$39	2026-06-04	Buy

Product number	Packaging	Price	Buy
643467	5g	$82.4	Buy
643467	25g	$313	Buy
HFA71090	10g	$354	Buy
OR921732	1g	$21	Buy
OR921732	5g	$39	Buy

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production

Synthesis

5317-32-8

24424-99-5

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

132710-90-8

GENERAL STEPS: 3-(Piperazin-1-yl)propan-1-ol (1.44 g, 10 mmol), di-tert-butyl dicarbonate (3.3 g, 15 mmol), and N,N-diisopropylethylamine (1.80 g, 15 mmol) were dissolved in dichloromethane (100 mL) and stirred at room temperature until the reaction was complete. After the reaction was complete, the reaction mixture was diluted with dichloromethane (200 mL). The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (eluent: dichloromethane/methanol = 20:1) to afford tert-butyl 4-(3-hydroxypropyl)piperazine-1-carboxylate as a colorless oil (2.4 g, 97% yield).

References

[1] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 137
[2] Patent: WO2016/191172, 2016, A1. Location in patent: Page/Page column 83
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 15, p. 6516 - 6527
[4] Patent: WO2009/10491, 2009, A1. Location in patent: Page/Page column 56
[5] Patent: US2009/99172, 2009, A1. Location in patent: Page/Page column 29

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

1-Piperazinepropanol 1-BOC-Piperazine 3-Bromo-1-propanol Di-tert-butyl dicarbonate Dichloromethane

N,N-Diisopropylethylamine

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Preparation Products

3-chloro-2,4,5-trifluoro-Benzenepropanoic acid ethyl ester

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

Global( 87)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; 19817745290	bd@blocksynth.com	China	5971	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49860	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43303	58
Aladdin Scientific		tp@aladdinsci.com	United States	54746	58
Suzhou ARTK Medchem Co., Ltd.	+86-18168183658	sales1@artkmedchem.com	China	39007	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
ROSEWA HOLDING GROUP CO.,LIMITED	+86-023-62871537	sales@rosewachem.com	China	2812	58

Supplier	Advantage
Fuxin Pharmaceutical	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Alfa Chemistry	58
GIHI CHEMICALS CO.,LIMITED	58
HANGZHOU LEAP CHEM CO., LTD.	58
Aladdin Scientific	58
Suzhou ARTK Medchem Co., Ltd.	58
Amadis Chemical Company Limited	58
ROSEWA HOLDING GROUP CO.,LIMITED	58

View Lastest Price from 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-12-04	4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 132710-90-8			98%	100kg	Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
132710-90-8
98%
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Spectrum

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(132710-90-8)¹HNMR 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(132710-90-8)FT-IR

132710-90-8(4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER)Related Search:

4-(5-Nitro-pyridin-2-yloxy)-piperidine-1-carboxylic acid tert-butyl ester 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester tert-Butyl 4-((6-bromopyridin-3-yl)methyl)piperazine-1-carboxylate tert-Butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester

tert-butyl 4-(6-bromopyridin-3-yl)piperazine-1-carboxylate tert-butyl 4-((6-aminopyridin-3-yl)methyl)piperazine-1-carboxylate tert-butyl 4-(aMinoMethyl)-4-cyanopiperidine-1-carboxylate tert-Butyl 4-[(5-aminopyridin-2-yl)oxy]piperidine-1-carboxylate 4-(2-Amino-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate tert-butyl 4-(3-bromo-6-chloropyridin-2-yl)piperazine-1-carboxylate tert-butyl 4-(4-amino-3-(trifluoromethyl)phenyl)piperazine-1-carboxylate tert-butyl 4-(4-amino-2,6-difluorophenyl)piperazine-1-carboxylate tert-butyl 4-(3-fluoro-4-nitrophenyl)piperazine-1-carboxylate

tert-Butyl 4-(5-fluoro-2-nitrophenyl)-piperazine-1-carboxylate tert-butyl 4-(3-phenylpropyl)piperazine-1-carboxylate tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate

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tert-Butyl 4-(2-hydroxypropyl)piperazine-1-carboxylate 1-Boc-4-(3-hydroxypropyl)piperazine 4-(2-HYDROXYPROPYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 1-Piperazinecarboxylic acid, 4-(3-hydroxypropyl)-, 1,1-dimethylethyl ester 1-Boc-4-(3-hydroxypropyl)piperazine,97% 1,1-Dimethylethyl 4-(3-hydroxypropyl)-1-piperazinecarboxylate tert-Butyl 4-(3-hydroxy-propyl)-1-piperazinecarboxylate 132710-90-8 API intermediates