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4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER structure

CAS No.: 132710-90-8

Chemical Name:: 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Synonyms: 1-Boc-4-(3-hydroxypropyl)piperazine,97%;tert-Butyl 4-(2-hydroxypropyl)piperazine-1-carboxylate;tert-Butyl 4-(3-hydroxy-propyl)-1-piperazinecarboxylate;1-Boc-4-(3-hydroxypropyl)piperazine;1,1-Dimethylethyl 4-(3-hydroxypropyl)-1-piperazinecarboxylate;4-(2-HYDROXYPROPYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER;1-Piperazinecarboxylic acid, 4-(3-hydroxypropyl)-, 1,1-dimethylethyl ester

CBNumber:: CB0430292

Molecular Formula:: C12H24N2O3

Molecular Weight:: 244.33

MDL Number:: MFCD06657040

MOL File:: 132710-90-8.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:14

Product description	Number	Pack Size	Price
1-Boc-4-(3-hydroxypropyl)piperazine 97%	643467	5g	$82.4
1-Boc-4-(3-hydroxypropyl)piperazine 97%	643467	25g	$313
tert-Butyl4-(3-Hydroxypropyl)piperazine-1-carboxylate	T135833	10mg	$45
tert-Butyl4-(3-Hydroxypropyl)piperazine-1-carboxylate	T135833	100mg	$75
tert-Butyl4-(2-hydroxypropyl)piperazine-1-carboxylate	6000AA	100g	$774

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4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Properties

Melting point	73-77 °C (lit.)
Boiling point	355.8±37.0 °C(Predicted)
Density	1.074±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	15.10±0.10(Predicted)
form	Solid
Appearance	White to off-white Solid
InChI	1S/C12H24N2O3/c1-12(2,3)17-11(16)14-8-6-13(7-9-14)5-4-10-15/h15H,4-10H2,1-3H3
InChIKey	LRYRQGKGCIUVON-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCN(CCCO)CC1
CAS DataBase Reference	132710-90-8
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P301+P310+P330-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

25-36/37/38

Safety Statements

26-36/37/39-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

HazardClass

6.1

HS Code

2924297099

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
3		0

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	643467	1-Boc-4-(3-hydroxypropyl)piperazine 97%	132710-90-8	5g	$82.4	2026-03-19	Buy
Sigma-Aldrich	643467	1-Boc-4-(3-hydroxypropyl)piperazine 97%	132710-90-8	25g	$313	2026-03-19	Buy
TRC	T135833	tert-Butyl4-(3-Hydroxypropyl)piperazine-1-carboxylate	132710-90-8	10mg	$45	2021-12-16	Buy
TRC	T135833	tert-Butyl4-(3-Hydroxypropyl)piperazine-1-carboxylate	132710-90-8	100mg	$75	2021-12-16	Buy
AK Scientific	6000AA	tert-Butyl4-(2-hydroxypropyl)piperazine-1-carboxylate	132710-90-8	100g	$774	2021-12-16	Buy

Product number	Packaging	Price	Buy
643467	5g	$82.4	Buy
643467	25g	$313	Buy
T135833	10mg	$45	Buy
T135833	100mg	$75	Buy
6000AA	100g	$774	Buy

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production

Synthesis

5317-32-8

24424-99-5

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

132710-90-8

GENERAL STEPS: 3-(Piperazin-1-yl)propan-1-ol (1.44 g, 10 mmol), di-tert-butyl dicarbonate (3.3 g, 15 mmol), and N,N-diisopropylethylamine (1.80 g, 15 mmol) were dissolved in dichloromethane (100 mL) and stirred at room temperature until the reaction was complete. After the reaction was complete, the reaction mixture was diluted with dichloromethane (200 mL). The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (eluent: dichloromethane/methanol = 20:1) to afford tert-butyl 4-(3-hydroxypropyl)piperazine-1-carboxylate as a colorless oil (2.4 g, 97% yield).

References

[1] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 137
[2] Patent: WO2016/191172, 2016, A1. Location in patent: Page/Page column 83
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 15, p. 6516 - 6527
[4] Patent: WO2009/10491, 2009, A1. Location in patent: Page/Page column 56
[5] Patent: US2009/99172, 2009, A1. Location in patent: Page/Page column 29

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

1-Piperazinepropanol 1-BOC-Piperazine 3-Bromo-1-propanol Di-tert-butyl dicarbonate Dichloromethane

N,N-Diisopropylethylamine

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Preparation Products

3-chloro-2,4,5-trifluoro-Benzenepropanoic acid ethyl ester

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5973	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49968	58
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.	+8613601750004	lizhi@pharoschem.com	China	439	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Labnetwork lnc.	58
GIHI CHEMICALS CO.,LIMITED	58
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-12-04	4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 132710-90-8	US $0.00-0.00 / kg	0.1kg	98%	100kg	Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
132710-90-8
US $0.00-0.00 / kg
98%
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Spectrum

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(132710-90-8)¹HNMR 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(132710-90-8)FT-IR

132710-90-8(4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER)Related Search:

4-(5-Nitro-pyridin-2-yloxy)-piperidine-1-carboxylic acid tert-butyl ester 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester tert-Butyl 4-((6-bromopyridin-3-yl)methyl)piperazine-1-carboxylate tert-Butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester

tert-butyl 4-(6-bromopyridin-3-yl)piperazine-1-carboxylate tert-butyl 4-((6-aminopyridin-3-yl)methyl)piperazine-1-carboxylate tert-butyl 4-(aMinoMethyl)-4-cyanopiperidine-1-carboxylate tert-Butyl 4-[(5-aminopyridin-2-yl)oxy]piperidine-1-carboxylate 4-(2-Amino-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate tert-butyl 4-(3-bromo-6-chloropyridin-2-yl)piperazine-1-carboxylate tert-butyl 4-(4-amino-3-(trifluoromethyl)phenyl)piperazine-1-carboxylate tert-butyl 4-(4-amino-2,6-difluorophenyl)piperazine-1-carboxylate tert-butyl 4-(3-fluoro-4-nitrophenyl)piperazine-1-carboxylate

tert-Butyl 4-(5-fluoro-2-nitrophenyl)-piperazine-1-carboxylate tert-butyl 4-(3-phenylpropyl)piperazine-1-carboxylate tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate

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tert-Butyl 4-(2-hydroxypropyl)piperazine-1-carboxylate 1-Boc-4-(3-hydroxypropyl)piperazine 4-(2-HYDROXYPROPYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 1-Piperazinecarboxylic acid, 4-(3-hydroxypropyl)-, 1,1-dimethylethyl ester 1-Boc-4-(3-hydroxypropyl)piperazine,97% 1,1-Dimethylethyl 4-(3-hydroxypropyl)-1-piperazinecarboxylate tert-Butyl 4-(3-hydroxy-propyl)-1-piperazinecarboxylate 132710-90-8 API intermediates