3,5-Difluorophenylboronic acid
- CAS No.
- 156545-07-2
- Chemical Name:
- 3,5-Difluorophenylboronic acid
- Synonyms
- AKOS BRN-0091;RARECHEM AH PB 0167;3,5-Difluorophenylbo;3,5-DIFLUOROPHENYLBORONIC ACID;3,5-DIFLUOROBENZENEBORONIC ACID;3,5-Difluorobenzeneboronicacid98%;3,5-DIFLUOROPHENYLBORONIC ACID 98%;3,5-Difluorophenylboronic acid,98%;3,5-Difluorophenylboronic acid Cas;3,5-Difluorobenzeneboronic acid 98%
- CBNumber:
- CB0437413
- Molecular Formula:
- C6H5BF2O2
- Molecular Weight:
- 157.91
- MDL Number:
- MFCD01318138
- MOL File:
- 156545-07-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3,5-Difluorophenylboronic acid | 471925 | 5g | $66.4 |
| 3,5-Difluorophenylboronic acid | 471925 | 25g | $305 |
| 3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride) | D3081 | 5g | $25 |
| 3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride) | D3081 | 25g | $76 |
| 3,5-DIFLUOROPHENYL BORONIC ACID 98% | 58436 | 25G | $27 |
| More product size | |||
| Melting point | 210-217 °C (lit.) |
|---|---|
| Boiling point | 266.9±50.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 6.46±0.10(Predicted) |
| form | powder |
| color | White to Orange to Green |
| BRN | 6800882 |
| InChI | InChI=1S/C6H5BF2O2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,10-11H |
| InChIKey | QWQBQRYFWNIDOC-UHFFFAOYSA-N |
| SMILES | B(C1=CC(F)=CC(F)=C1)(O)O |
| CAS DataBase Reference | 156545-07-2(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn,F | |||||||||
| Risk Statements | 36/37/38-20-19-11-22 | |||||||||
| Safety Statements | 26-36-33-16-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3,5-Difluorophenylboronic acid price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 471925 | 3,5-Difluorophenylboronic acid | 156545-07-2 | 5g | $66.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 471925 | 3,5-Difluorophenylboronic acid | 156545-07-2 | 25g | $305 | 2026-04-30 | Buy |
| TCI Chemical | D3081 | 3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride) | 156545-07-2 | 5g | $25 | 2026-04-30 | Buy |
| TCI Chemical | D3081 | 3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride) | 156545-07-2 | 25g | $76 | 2026-04-30 | Buy |
| AstaTech | 58436 | 3,5-DIFLUOROPHENYL BORONIC ACID 98% | 156545-07-2 | 25G | $27 | 2026-04-30 | Buy |
3,5-Difluorophenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
White to beige-yellowish powder
Uses
Reactant involved in:• ;Synthesis of honokiol analogs as angiogenesis inhibitors1• ;Homo-coupling reactions2• ;Suzuki-Miyaura cross-coupling reactions3• ;Enantioselective borane reduction of trifluoroacetophenone4
Uses
suzuki reaction
Uses
3,5-Difluorophenylboronic Acid is used in the synthesis of N-thiazol-2-yl-benzamides as glucokinase (GK) activators for treatment of type 2 diabetes mellitus (T2DM).
Uses
Intermediates of Liquid Crystals
Synthesis
121-43-7
461-96-1
156545-07-2
(1) A solution was prepared by dissolving 100 g of 3,5-difluorobromobenzene in 150 mL of tetrahydrofuran (THF) under nitrogen protection. The solution was slowly added dropwise to a mixture containing 13.85 g of magnesium shavings and 55 mL of THF at a controlled titration rate to keep the reaction system at mild reflux. (2) After the dropwise addition was completed, the reaction mixture was stirred at 40°C for 1 hour and subsequently cooled in an ice bath. (3) A solution prepared from 64.59 g of trimethyl borate dissolved in 130 mL of THF was slowly added dropwise under ice bath cooling. After completion of the dropwise addition, the ice bath was removed and the reaction mixture was continued to be stirred at room temperature for 1 hour. (4) 10% hydrochloric acid solution was added dropwise to the reaction system until the system became acidic, followed by stirring at room temperature for 30 minutes. (5) The organic layer was separated and the aqueous layer was extracted with hexane. The organic layer and hexane extract were combined and washed with saturated saline. (6) The washed organic layer was dried by adding anhydrous sodium sulfate, filtered and distilled under reduced pressure to remove the solvent to obtain 71.65 g of 3,5-difluorophenylboronic acid.
References
[1] Patent: US5521192, 1996, A
[2] Patent: US6908914, 2005, B1
[3] Patent: EP2123623, 2009, A1. Location in patent: Page/Page column 43-44
[4] Patent: US2014/275577, 2014, A1. Location in patent: Paragraph 0094
3,5-Difluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13843 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 904 | 58 |
View Lastest Price from 3,5-Difluorophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | (3,5-Difluorophenyl)boronic acid
156545-07-2
|
US $6.00-0.60 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-04-04 | 3,5-Difluorophenylboronic acid
156545-07-2
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2023-05-04 | 3,5-Difluorophenylboronic acid Cas
156545-07-2
|
US $48.00-40.00 / Kg | 10KG | 99 | 200tons | Guangzhou Sunton Biotechnology Co., Ltd. |
-
- (3,5-Difluorophenyl)boronic acid
156545-07-2
- US $6.00-0.60 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3,5-Difluorophenylboronic acid
156545-07-2
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3,5-Difluorophenylboronic acid Cas
156545-07-2
- US $48.00-40.00 / Kg
- 99
- Guangzhou Sunton Biotechnology Co., Ltd.
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