Isopropyl palmitate
- CAS No.
- 142-91-6
- Chemical Name:
- Isopropyl palmitate
- Synonyms
- ISOPROPYL HEXADECANOATE;Deltyl;plymouthipp;ISOPROPYLPALMITAT;kesscoisopropylpalmitate;Isopropyl Palmitate (IPP);Isopal;Isopalm;Emcol-IP;estol103
- CBNumber:
- CB0451826
- Molecular Formula:
- C19H38O2
- Molecular Weight:
- 298.5
- MDL Number:
- MFCD00008993
- MOL File:
- 142-91-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 11-13 °C (lit.) |
|---|---|
| Boiling point | 160°C 2mm |
| Density | 0.852 g/mL at 25 °C (lit.) |
| vapor pressure | 0.007Pa at 25℃ |
| refractive index |
n |
| FLAVIS Number | 09.606 | Isopropyl hexadecanoate |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | <0.001g/l |
| form | <11°C Solid,>13°C Liquid |
| color | Colourless |
| Odor | very sl. odor |
| biological source | synthetic |
| Water Solubility | Not miscible or difficult to mix with water. |
| BRN | 1786567 |
| Henry's Law Constant | 2.1×10-4 mol/(m3Pa) at 25℃, HSDB (2015) |
| Cosmetics Ingredients Functions |
PERFUMING BINDING FRAGRANCE SKIN CONDITIONING - EMOLLIENT |
| Cosmetic Ingredient Review (CIR) | Isopropyl palmitate (142-91-6) |
| InChI | 1S/C19H38O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19(20)21-18(2)3/h18H,4-17H2,1-3H3 |
| InChIKey | XUGNVMKQXJXZCD-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCC(=O)OC(C)C |
| LogP | 8.16 |
| CAS DataBase Reference | 142-91-6(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | ISOPROPYL PALMITATE |
| FDA 21 CFR | 310.545 |
| EWG's Food Scores | 1 |
| FDA UNII | 8CRQ2TH63M |
| NIST Chemistry Reference | Isopropyl palmitate(142-91-6) |
| EPA Substance Registry System | Isopropyl palmitate (142-91-6) |
| Cosmetics Info | Isopropyl Palmitate |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313 | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | RT4900000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29157090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazardous Substances Data | 142-91-6(Hazardous Substances Data) | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),National Technical Information Service. Vol. AD277-689, | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Isopropyl palmitate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W515604 | Isopropyl palmitate ≥90% | 142-91-6 | 1 each | $63.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | I0725000 | Isopropyl hexadecanoate European Pharmacopoeia (EP) Reference Standard | 142-91-6 | 100 mg | $175 | 2026-04-30 | Buy |
| Sigma-Aldrich | 291781 | Isopropyl palmitate technical grade, 90% | 142-91-6 | 1l | $86.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1350603 | Isopropyl palmitate United States Pharmacopeia (USP) Reference Standard | 142-91-6 | 500mg | $453 | 2026-04-30 | Buy |
| Sigma-Aldrich | W515604 | Isopropyl palmitate ≥90% | 142-91-6 | 1 unit | $61.7 | 2025-07-31 | Buy |
Isopropyl palmitate Chemical Properties,Uses,Production
Chemical Properties
Clear colorless liquid
Chemical Properties
Isopropyl palmitate is a clear, colorless to pale yellow-colored, practically odorless viscous liquid that solidifies at less than 16°C.
Uses
Pharmaceutic aid (vehicle, oleaginous).
Uses
isopropyl palmitate is an emollient and moisturizer, it also acts as a binder and solvent. Similar to isopropyl myristate, it is produced from the combination of palmitic acid (coconut or palm oil) and isopropyl alcohol. enzymes are able to metabolize this ingredient and studies do not show allergic reactions or toxicity. Some sources indicate comedogenicity potential.
Uses
Isopropyl palmitate is used to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application and to characterize microemulsion systems of isopropyl palmitate, water and 2:1 Brij 97, and 1-butanol by different experimental techniques.
Definition
ChEBI: Isopropyl palmitate is a fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a fatty acid ester and an isopropyl ester. It is functionally related to a hexadecanoic acid.
Production Methods
Isopropyl palmitate is prepared by the reaction of palmitic acid with propan-2-ol in the presence of an acid catalyst. A high-purity material is also commercially available, which is produced by enzymatic esterification at low temperatures.
General Description
Isopropyl palmitate is an analog of isopropyl myristate and an aliphatic ester used as a flavoring ingredient in food industry. It is one of the volatile compounds found in Psidium salutare fruits and boiled buckwheat flour.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical Applications
Isopropyl palmitate is a nongreasy emollient with good spreading
characteristics, used in topical pharmaceutical formulations and
cosmetics such as: bath oils; creams; lotions; make-up; hair care
products; deodorants; lip products; suntan preparations; and
pressed powders.
Isopropyl palmitate is an established penetration enhancer for
transdermal systems. It has also been used in controlled-release
percutaneous films.
Table I: Uses of isopropyl palmitate
Side effects
Side effects for the skin: If overused, isopropyl palmitate may cause acne, blackheads, whiteheads, and clogged pores. Depending on the content of the ingredients in the product, the skin may experience some irritation. If isopropyl palmitate is used without dilution, it may cause comedoles. People with oily skin should also avoid isopropyl palmitate.
Side effects for hair: Excessive use of products containing isopropyl palmitate on hair can make hair look untidy, oily, and untidy due to excessive moisture in the hair. When there is an open wound on the scalp, isopropyl palmitate should also be avoided.
Safety
Isopropyl palmitate is widely used in cosmetics and topical
pharmaceutical formulations, and is generally regarded as a
relatively nontoxic and nonirritant material.
LD50 (mouse, IP): 0.1 g/kg
storage
Isopropyl palmitate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container, above 16°C, and protected from light.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical and transdermal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Isopropyl palmitate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Birdge Chemical (shanghai) Co.,Ltd. | 13248325872 | sales@bridgechemical.net | China | 72 | 58 |
| BLiT (Hefei)Chemical Co.,Ltd | 62622640 13225513950 | leo@blitchem.com | China | 288 | 58 |
| TINAMEN | 15607209205 | tianmenzhengyi@qq.com | China | 12 | 58 |
| Wuhan penglei Biotechnology Co., Ltd | 15871464247 17307245989 | 3471278124@qq.com | China | 4990 | 58 |
| Hubei Yushenghe Biotechnology Co, Ltd | 13307209205 | 13307209205@163.cn | China | 15 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
Related articles
- Synthesis of Isopropyl palmitate
- Isopropyl palmitate is prepared by a two step lipase catalysed hydrolysis reaction with palm stearin as the raw material.
- Dec 25,2023
View Lastest Price from Isopropyl palmitate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Isopropyl palmitate
142-91-6
|
1kg /Drum | ≥98% | 50 T/Month | Hebei Qujie Technology Co., Ltd. | ||
 |
2026-09-11 | Isopropyl palmitate
142-91-6
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-10 | Isopropyl Palmitate (IPP)
142-91-6
|
$410.00 | 175kg | 98% | 10 tons | Gansu Jinyuantai New Material Co., Ltd. |
-
- Isopropyl palmitate
142-91-6
- $0.00
- ≥98%
- Hebei Qujie Technology Co., Ltd.
-
- Isopropyl palmitate
142-91-6
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Isopropyl Palmitate (IPP)
142-91-6
- $410.00
- 98%
- Gansu Jinyuantai New Material Co., Ltd.
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