O-Phospho-L-serine
- CAS No.
- 407-41-0
- Chemical Name:
- O-Phospho-L-serine
- Synonyms
- 3-phospho-L-serine;L O;P-ser;L-SOP;L-O-(RG);Seriphos;P-serine;Fosforina;3-P-SERINE;Phospho Ser
- CBNumber:
- CB0456205
- Molecular Formula:
- C3H8NO6P
- Molecular Weight:
- 185.07
- MDL Number:
- MFCD00065935
- MOL File:
- 407-41-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| O-Phospho-L-serine | P0878 | 1g | $36 |
| Monoclonal Anti-Phosphoserine antibody produced in mouse clone PSR-45, ascites fluid | P3430 | 100μL | $575 |
| Monoclonal Anti-Phosphoserine antibody produced in mouse clone PSR-45, ascites fluid | P3430 | 0.2mL | $784 |
| O-Phospho-L-serine certified reference material, TraceCERT | 72983 | 100mg | $202 |
| L-Serine-O-phosphate - CAS 407-41-0 - Calbiochem | 5.09705 | 1g | $63.1 |
| More product size | |||
| Melting point | 190 °C(lit.) |
|---|---|
| alpha | [α]D20 +14～+18°(c=5,dil.HCl) |
| Boiling point | 475.4±55.0 °C(Predicted) |
| Density | 1.809±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 20℃ |
| storage temp. | under inert gas |
| solubility | H2O: 50 mg/mL hot, clear, colorless to slightly yellow |
| form | Crystalline Powder |
| pka | pK1:2.08;pK2:5.65;pK3:9.74 (25°C) |
| color | White |
| biological source | mouse |
| optical activity | +16.221 (2 mol dm-3 HCl) |
| Water Solubility | 28.34g/L at 20℃ |
| Merck | 14,7363 |
| BRN | 1726826 |
| Cosmetics Ingredients Functions |
SKIN CONDITIONING HAIR CONDITIONING |
| InChI | 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 |
| InChIKey | BZQFBWGGLXLEPQ-UWTATZPHSA-N |
| SMILES | N[C@@H](COP(O)(O)=O)C(O)=O |
| CAS DataBase Reference | 407-41-0(CAS DataBase Reference) |
| FDA UNII | VI4F0K069V |
| UNSPSC Code | 12352209 |
| NACRES | NA.44 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 21/22 | |||||||||
| Safety Statements | 36/37 | |||||||||
| RIDADR | UN 3261 8 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HS Code | 29225090 | |||||||||
| Storage Class | 8B - Non-combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
O-Phospho-L-serine price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0878 | O-Phospho-L-serine | 407-41-0 | 1g | $36 | 2026-04-30 | Buy |
| Sigma-Aldrich | P3430 | Monoclonal Anti-Phosphoserine antibody produced in mouse clone PSR-45, ascites fluid | 407-41-0 | 100μL | $575 | 2026-04-30 | Buy |
| Sigma-Aldrich | P3430 | Monoclonal Anti-Phosphoserine antibody produced in mouse clone PSR-45, ascites fluid | 407-41-0 | 0.2mL | $784 | 2026-04-30 | Buy |
| Sigma-Aldrich | 72983 | O-Phospho-L-serine certified reference material, TraceCERT | 407-41-0 | 100mg | $202 | 2026-04-30 | Buy |
| Sigma-Aldrich | 5.09705 | L-Serine-O-phosphate - CAS 407-41-0 - Calbiochem | 407-41-0 | 1g | $63.1 | 2022-05-15 | Buy |
O-Phospho-L-serine Chemical Properties,Uses,Production
Description
O-
Chemical Properties
White powder
Uses
roborant
Uses
L-O-Phosphoserine is the catalytic domain of human protein kinase C β II when complexed with a malemide inhibitor. It is also used in the purification of the Epstein-Barr virus nuclear antigen 2A.
Uses
O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
Definition
ChEBI: O-phospho-L-serine is the L-enantiomer of O-phosphoserine. It has a role as an EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, an EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor, an EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor and a mouse metabolite. It is a conjugate acid of an O-phosphonato-L-serine(2-). It is an enantiomer of an O-phospho-D-serine.
General Description
Monoclonal Anti-Phosphoserine (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Flammability and Explosibility
Not classified
Biological Activity
Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Biochem/physiol Actions
Protein phosphorylation and dephosphorylation are basic signaling mechanisms that modify protein function in eukaryotic cells. Phosphorylation is a rare posttranslational event in normal tissues, however, the abundance of phosphorylated cellular proteins increases several folds following various activation processes. The main amino acids that are phosphorylated are tyrosine, serine, or threonine (pTyr/pSer/pThr), each having specific kinases that phosphorylate them and specific phosphatases that dephosphorylate them. Mono and polyclonal antibodies directed against phosphorylated residues were generated and found useful as analytical and preparative tools by enabling the identification, quantification, and immunoaffinity isolation of phosphorylated cellular proteins.
storage
Room temperature
Purification Methods
Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.]
References
[1] L ERIKSEN C T. [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a.[J]. British Journal of Pharmacology, 1995, 116 8: 3279-3287. DOI: 10.1111/j.1476-5381.1995.tb15136.x
[2] P J CONN J P P. Pharmacology and functions of metabotropic glutamate receptors.[J]. Annual review of pharmacology and toxicology, 1997, 37: 205-237. DOI: 10.1146/annurev.pharmtox.37.1.205
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[4] TRAVIS J. BAILEY. The inhibitor of phagocytosis, O-phospho-l-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina[J]. Experimental eye research, 2010, 91 5: Pages 601-612. DOI: 10.1016/j.exer.2010.07.017
[5] JONATHAN P SAXE. A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.[J]. Chemistry & biology, 2007, 14 9: 1019-1030. DOI: 10.1016/j.chembiol.2007.07.016
O-Phospho-L-serine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 | admin@hblongbang.com | China | 972 | 58 |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 | L18532138899@163.com | China | 939 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9542 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
View Lastest Price from O-Phospho-L-serine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-29 | O-Phospho-L-serine
407-41-0
|
US $0.00-0.00 / Kg/Drum | 1KG | 98%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-05-11 | O-Phospho-L-serine
407-41-0
|
US $70.00-31.00 / mg | 98.23% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-11 | O-Phospho-L-serine
407-41-0
|
US $70.00-31.00 / mg | 98.23% | 10g | TargetMol Chemicals Inc. |
-
- O-Phospho-L-serine
407-41-0
- US $0.00-0.00 / Kg/Drum
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- O-Phospho-L-serine
407-41-0
- US $70.00-31.00 / mg
- 98.23%
- TargetMol Chemicals Inc.
-
- O-Phospho-L-serine
407-41-0
- US $70.00-31.00 / mg
- 98.23%
- TargetMol Chemicals Inc.
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