MRE11 ANTIBODY
- CAS No.
- Chemical Name:
- MRE11 ANTIBODY
- Synonyms
- MRE11 ANTIBODY;Mouse Monoclonal MRE11 Antibody
- CBNumber:
- CB04730613
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
MRE11 ANTIBODY price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb622264 | Mre11 Antibody | 50μl | $400 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb841041 | MRE11 Antibody | 2mg | $2420 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb622264 | Mre11 Antibody | 100μl | $540 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb570732 | MRE11 Antibody | 50μg | $140 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb570732 | MRE11 Antibody | 100μg | $220 | 2026-05-06 | Buy |
MRE11 ANTIBODY Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
Mre11, originally described in genetic screens from the yeast Saccharomyces cerevisiae in which mutants were defective in meiotic recombination, is a central part of a multisubunit nuclease composed of Mre11, Rad50 and Nbs1. The MRN complex plays a critical role in sensing, processing and repairing DNA double strand breaks. Defects lead to genomic instability, telomere shortening, aberrant meiosis and hypersensitivity to DNA damage. Hypomorphic mutations of Mre11 are found in ataxia-telangiectasia-like disease, with phenotypes similar to mutations in ATM that cause ataxia-telangiectasia, including a predisposition to malignancy in humans. Cellular consequences of ATLD include chromosomal instability and defects in the intra-S phase and G2/M checkpoints in response to DNA damage. The MRN complex may directly activate the ATM checkpoint kinase at DNA breaks.
References
[1] Ajimura, M. et al. (1993) Genetics 133, 51-66.
[2] D'Amours, D. and Jackson, S.P. (2002) Nat Rev Mol Cell Biol 3, 317-27.
[3] van den Bosch, M. et al. (2003) EMBO Rep 4, 844-9.
[4] Theunissen, J.W. et al. (2003) Mol Cell 12, 1511-23.
[5] Stewart, G.S. et al. (1999) Cell 99, 577-87.
[6] Carson, C.T. et al. (2003) EMBO J 22, 6610-20.
MRE11 ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
MRE11 ANTIBODY Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
