NOD1 ANTIBODY
- CAS No.
- Chemical Name:
- NOD1 ANTIBODY
- Synonyms
- NOD1 ANTIBODY
- CBNumber:
- CB04730996
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
NOD1 ANTIBODY price More Price(2)
NOD1 ANTIBODY Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria. It contains an amino-terminal caspase recruitment domain that is linked to a central nucleotide-binding domain and is followed by carboxy-terminal leucine-rich repeats. Like Apaf-1, Nod1 induces apoptosis by a CARD/NBD-dependent activation of caspase-9. The primary function of Nod1 is thought to be as a sensor for certain pathogenic microbes and triggering inflammatory responses including the activation of NF-κB and JNK pathways. The LRR of Nod1 appears to be involved in recognition of microbial components and the CARD domain induces NF-κB activation in cooperation with the CARD containing kinase, RICK/RIP2/CARDIAK. Mutations in Nod1 have been linked increased susceptibility to asthma and inflammatory bowel disease.
References
[1] Inohara, N. et al. (1999) J. Biol. Chem. 274, 14560-14567.
[2] Inohara, N. and Nuñez, G. (2003) Nat. Rev. Immunol. 3, 371-382.
[3] Fritz, J.H. et al. (2006) Nat .Immunol. 7, 1250-1257.
[4] Girardin, S.E. et al. (2001) EMBO Rep. 2, 736-742.
[5] Inohara, N. et al. (2001) J. Biol. Chem. 276, 2551-2554.
[6] Inohara, N. et al. (2000) J. Biol. Chem. 275, 27823-27831.
[7] Hysi, P. et al. (2005) Hum. Mol. Genet. 14, 935-941.
[8] McGovern, D.P. et al. (2005) Hum. Mol. Genet. 14, 1245-1250.
NOD1 ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
NOD1 ANTIBODY Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
