CH7057288
- CAS No.
- 2095616-82-1
- Chemical Name:
- CH7057288
- Synonyms
- CH7057288;CH7057288, 10 mM in DMSO;Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288;4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
- CBNumber:
- CB04797034
- Molecular Formula:
- C32H31N3O5S
- Molecular Weight:
- 569.67
- MDL Number:
- MOL File:
- 2095616-82-1.mol
CH7057288 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 25mg | $1100 | 2021-12-16 | Buy |
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 50mg | $1750 | 2021-12-16 | Buy |
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 100mg | $2750 | 2021-12-16 | Buy |
CH7057288 Chemical Properties,Uses,Production
Uses
CH7057288 is a potent and selective TRK inhibitor. CH7057288 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity
CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
in vitro
In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways.
target
| Target | Value |
| TrkA (Cell-free assay) | 1.1 nM |
| TrkC (Cell-free assay) | 5.1 nM |
| 7.8 nM |
IC 50
TRK
References
[1] Hiroshi Tanaka, et al. Abstract 4179: Potent and selective TRK inhibitor CH7057288. AACR Annual Meeting 2017; April 1-5, 2017.
CH7057288 Preparation Products And Raw materials
Raw materials
Preparation Products
CH7057288 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18157 | 56 |
