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3,5-Dichloro-4-hydroxybenzoic acid

3,5-Dichloro-4-hydroxybenzoic acid Structure
3,5-Dichloro-4-hydroxybenzoic acid structure
CAS No.
3336-41-2
Chemical Name:
3,5-Dichloro-4-hydroxybenzoic acid
Synonyms
,5-Dichloro-4-hydroxybenzoic acid;2-(benzo[d]thiazol-3(2H)-yl)-1-(3,5-dichloro-4-methoxyphenyl)ethanone;AKOS BBS-00006921;RARECHEM AL BE 0933;Dotinurad Impurity 34;Dotinurad Impurity 24;LABOTEST-BB LT00454970;Tetrahydrozoline Impurity 4;3,5-dichloro-4-hydroxybenzoate;3,5-dichloro-4-hydroxy-benzoicaci
CBNumber:
CB0480631
Molecular Formula:
C7H4Cl2O3
Molecular Weight:
207.01
MDL Number:
MFCD00002550
MOL File:
3336-41-2.mol
MSDS File:
SDS
Last updated:2026-05-27 22:44:56
Product description Number Pack Size Price
3,5-Dichloro-4-hydroxybenzoic acid 97% D64007 25g $111
3,5-Dichloro-4-hydroxybenzoic Acid >98.0%(T) D0373 5g $28
3,5-Dichloro-4-hydroxybenzoic Acid >98.0%(T) D0373 25g $77
3,5-Dichloro-4-hydroxybenzoic Acid TRC-D438698-500MG 500mg $82
3,5-Dichloro-4-hydroxybenzoic Acid TRC-D438698-1G 1g $96
More product size
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3,5-Dichloro-4-hydroxybenzoic acid Properties

Melting point 264-266 °C (lit.)
Boiling point 297.29°C (rough estimate)
Density 1.5281 (rough estimate)
refractive index 1.4845 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 3.83±0.10(Predicted)
color White to Off-White
BRN 2616297
InChI InChI=1S/C7H4Cl2O3/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,10H,(H,11,12)
InChIKey AULKDLUOQCUNOK-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC(Cl)=C(O)C(Cl)=C1
CAS DataBase Reference 3336-41-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII Y8BF62TK9Q
NIST Chemistry Reference 3,5-Dichloro-4-hydroxybenzoic acid(3336-41-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  DG7502000
HS Code  29182900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
1 0

3,5-Dichloro-4-hydroxybenzoic acid price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D64007 3,5-Dichloro-4-hydroxybenzoic acid 97% 3336-41-2 25g $111 2023-06-20 Buy
TCI Chemical D0373 3,5-Dichloro-4-hydroxybenzoic Acid >98.0%(T) 3336-41-2 5g $28 2026-04-30 Buy
TCI Chemical D0373 3,5-Dichloro-4-hydroxybenzoic Acid >98.0%(T) 3336-41-2 25g $77 2026-04-30 Buy
TRC TRC-D438698-500MG 3,5-Dichloro-4-hydroxybenzoic Acid 3336-41-2 500mg $82 2026-06-03 Buy
TRC TRC-D438698-1G 3,5-Dichloro-4-hydroxybenzoic Acid 3336-41-2 1g $96 2026-06-03 Buy
Product number Packaging Price Buy
D64007 25g $111 Buy
D0373 5g $28 Buy
D0373 25g $77 Buy
TRC-D438698-500MG 500mg $82 Buy
TRC-D438698-1G 1g $96 Buy

3,5-Dichloro-4-hydroxybenzoic acid Chemical Properties,Uses,Production

Chemical Properties

White to light yellow crystal powder

Uses

3,5-Dichloro-4-hydroxybenzoic Acid can be used as cyclin dependent kinase inhibitors to treat cell proliferative disorders, such as, cancer.

Definition

ChEBI: 3,5-dichloro-4-hydroxybenzoic acid is a derivative of p-salicylic acid with chloro- substituents at C-3 and C-5 of the benzene ring. It is a monohydroxybenzoic acid and a dichlorobenzene. It is functionally related to a benzoic acid and a 4-hydroxybenzoic acid. It is a conjugate acid of a 3,5-dichloro-4-hydroxybenzoate.

Synthesis

4-Hydroxybenzoic acid

99-96-7

3,5-Dichloro-4-hydroxybenzoic acid

3336-41-2

The general procedure for the synthesis of 3,5-dichloro-4-hydroxybenzoic acid from 4-hydroxybenzoic acid was as follows: 10 mL of 33% hydrogen peroxide solution was slowly added to a suspension of 10 mL hydrochloric acid and 20 mL water containing 3.5 g (0.025 mol) of 4-hydroxybenzoic acid. Upon completion of the reaction, the resulting white precipitate was collected by filtration, washed well with hot water and purified by recrystallization from ethanol. Finally, 3.19 g of white crystalline product was obtained in 63.5% yield with a melting point of 265 °C. The 1H NMR spectral data of the product was as follows (ppm): 7.84 (s, 2H, H2,6). Elemental analysis results: measured values (%) C 40.64, H 1.87, Cl 34.34; calculated values (%) C 40.58, H 1.93, Cl 34.30 (molecular formula: C7H4Cl2O2).

References

[1] Organic Process Research and Development, 1999, vol. 3, # 1, p. 10 - 16
[2] Russian Journal of General Chemistry, 2015, vol. 85, # 3, p. 577 - 583
[3] Zh. Obshch. Khim., 2015, vol. 85, # 3, p. 413 - 419,7
[4] Zhurnal Obshchei Khimii, 1949, vol. 19, p. 1167,1168
[5] Chem. Zentralbl., 1950, vol. 121, p. 1063

3,5-Dichloro-4-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Ethylparaben 4-Hydroxybenzoic acid Hydrogen peroxide Hydrochloric acid

Preparation Products

3',5'-DICHLORO-4'-HYDROXYACETOPHENONE 3,5-DICHLORO-4-METHOXYBENZOIC ACID 2,6-DICHLORO-1,4-BENZOQUINONE METHYL 3,5-DICHLORO-4-METHOXYBENZOATE

3,5-Dichloro-4-hydroxybenzoic acid Suppliers

Global( 221)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3997 58
ShenZhen H&D Pharmaceutical Technology Co., LTD 		+8618627948422 sale@hdimpurity.com China 3681 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
GLR Innovations 		+91 9891111994 info@glrgroup.in India 4535 58
Aromsyn Co., Ltd. 		+86-0571-85585865 +8613336024896 CB@aromsyn.com China 19183 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
ShenZhen H&D Pharmaceutical Technology Co., LTD 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
GLR Innovations 		58
Aromsyn Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58

View Lastest Price from 3,5-Dichloro-4-hydroxybenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dotinurad Impurity 34 pictures 2026-03-12 Dotinurad Impurity 34
3336-41-2
 10mg 0.98 5g ShenZhen H&D Pharmaceutical Technology Co., LTD
3,5-Dichloro-4-hydroxybenzoic acid pictures 2025-12-01 3,5-Dichloro-4-hydroxybenzoic acid
3336-41-2
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
3,5-Dichloro-4-hydroxybenzoic acid pictures 2024-07-11 3,5-Dichloro-4-hydroxybenzoic acid
3336-41-2
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd

3,5-Dichloro-4-hydroxybenzoic acid Spectrum

3,5-Dichloro-4-hydroxybenzoic acid(3336-41-2)MS3,5-Dichloro-4-hydroxybenzoic acid(3336-41-2)1HNMR3,5-Dichloro-4-hydroxybenzoic acid(3336-41-2)IR13,5-Dichloro-4-hydroxybenzoic acid(3336-41-2)IR23,5-Dichloro-4-hydroxybenzoic acid(3336-41-2)Raman

3336-41-2(3,5-Dichloro-4-hydroxybenzoic acid)Related Search:

Butylparaben 3-CHLORO-4-HYDROXYBENZOIC ACID 2-Chloro-4-hydroxybenzoic acid 4-Hydroxybenzhydrazide 3-Hydroxybenzoic acid
4-Hydroxybenzoic acid Methyl 3,5-dihydroxybenzoate 2'-Hydroxy-3-phenylpropiophenone Benzylparaben 3,5-Dihydroxybenzoic acid
Salicylic acid Isopropylparaben Methylparaben 2,5-Dihydroxybenzoic acid 3,5-Dichlorobenzoic acid
3,5-DICHLORO-4-HYDROXYBENZOIC ACID ETHYL ESTER METHYL 3,5-DICHLORO-4-HYDROXYBENZOATE 3,5-DICHLORO-2-HYDROXYBENZOIC ACID

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3,5-dichloro-4-hydroxybenzoate 3,5-Dichloro-4-hydroxybenzoic acid,97% 3,5-Dichloro-4-hydroxybenzoic acid, 97% 5GR 3,5-dichloro-4-hydroxy-benzoicaci Benzoic acid, 3,5-dichloro-4-hydroxy- 4-Hydroxy-3,5-Dichloro Benzoic Acid 3,5-DICHLORO-4-HYDROXYBENZOIC ACID AKOS BBS-00006921 LABOTEST-BB LT00454970 RARECHEM AL BE 0933 3,5-Dichloro-4-hydroxybenzoic Acid > Tetrahydrozoline Impurity 4 Dotinurad Impurity 34 Dotinurad Impurity 24 ,5-Dichloro-4-hydroxybenzoic acid 2-(benzo[d]thiazol-3(2H)-yl)-1-(3,5-dichloro-4-methoxyphenyl)ethanone 3336-41-2 C7H4Cl2O3 C7H4O3Cl2 Building Blocks Carbonyl Compounds Carboxylic Acids C7 Organic Building Blocks Building Blocks Carbonyl Compounds Chemical Synthesis Organic Building Blocks Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Carboxylic Acids Phenyls & Phenyl-Het Benzoic acid Carboxylic Acids Phenyls & Phenyl-Het C7 Carbonyl Compounds Acids & Esters Chlorine Compounds Phenols