NAB 2
- CAS No.
- 1504588-00-4
- Chemical Name:
- NAB 2
- Synonyms
- NAB 2;alphaSYN-IN-NAB2;NAB2 >=98% (HPLC);alphaSYN inhibitor-NAB2;alphaSYN inhibitor NAB2;alphaSYN IN NAB2,alphaSYN-IN-NAB-2;Nedd4/Rsp5 Signaling Inducer, NAB2;N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide;1H-Benzimidazole-5-carboxamide, N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-;N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-1,3-benzodiazole-5-carboxamide
- CBNumber:
- CB04814917
- Molecular Formula:
- C23H20ClN3O
- Molecular Weight:
- 389.88
- MDL Number:
- MOL File:
- 1504588-00-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| NAB 2 | 26145 | 1mg | $93 |
| NAB 2 | 26145 | 10mg | $230 |
| NAB 2 | 26145 | 5mg | $161 |
| NAB2 ≥98%(HPLC) | 5131 | 50 | $861 |
| NAB2 ≥98%(HPLC) | 5131 | 10 | $206 |
| Density | 1.24±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO: 5 mg/mL |
| pka | 13.04±0.46(Predicted) |
| form | A crystalline solid |
| color | White to off-white |
| InChI | 1S/C23H20ClN3O/c1-15-7-8-16(2)22(11-15)27-14-26-20-12-17(9-10-21(20)27)23(28)25-13-18-5-3-4-6-19(18)24/h3-12,14H,13H2,1-2H3,(H,25,28) |
| InChIKey | CZSLEMCYYGEGKP-UHFFFAOYSA-N |
| SMILES | Clc1c(cccc1)CNC(=O)c2cc3nc[n](c3cc2)c4c(ccc(c4)C)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H413 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
NAB 2 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26145 | NAB 2 | 1504588-00-4 | 1mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 26145 | NAB 2 | 1504588-00-4 | 10mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 26145 | NAB 2 | 1504588-00-4 | 5mg | $161 | 2024-03-01 | Buy |
| Tocris | 5131 | NAB2 ≥98%(HPLC) | 1504588-00-4 | 50 | $861 | 2021-12-16 | Buy |
| Tocris | 5131 | NAB2 ≥98%(HPLC) | 1504588-00-4 | 10 | $206 | 2021-12-16 | Buy |
NAB 2 Chemical Properties,Uses,Production
Description
alphaSYN-IN-NAB2 is an inhibitor of α-synuclein mutations. It acts by reversing the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons and promoting E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport..
Uses
NAB2 is a neuroprotectant that targets the small GTPase Rab1a. NAB2 selectively binds to the GDP-bound form of Rab1a and protects multiple cell types from α-synuclein toxicity by increasing Rab1a expression. Rab1a regulates ER-to-Golgi trafficking and mediates endosomal trafficking events of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 stimulates ubiquitination of related proteins in a Nedd4-dependent manner and rescues α-synuclein-associated trafficking defects associated with early-onset Parkinson's disease[1][2][3].
Definition
ChEBI: N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)benzimidazole-5-carboxamide is an aromatic amide obtained by the formal condensation of the carboxy group of 1-(2,5-dimethylphenyl)benzimidazole-5-carboxylic acid with the amino group of 2-chlorobenzylamine. It is a member of benzimidazoles, an aromatic amide, a monocarboxylic acid amide and a member of monochlorobenzenes.
IC 50
α-synuclein
storage
Store at +4°C
References
[1] Tardiff DF, et al. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science. 2013;342(6161):979-983. DOI:10.1126/science.1245321
[2] Hatstat AK, et al. Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity. RSC Chem Biol. 2021 Nov 9;3(1):96-111. DOI:10.1039/d1cb00103e
NAB 2 Preparation Products And Raw materials
Raw materials
Preparation Products
NAB 2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10000 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9675 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-025-85560043 17301488900 | info@synzest.com | China | 9286 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44896 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 18351873721 | helen.zhang@synzest.com | China | 8295 | 58 |
