IWP-O1
- CAS No.
- 2074607-48-8
- Chemical Name:
- IWP-O1
- Synonyms
- IWO-O1;IWP-O1;IWP-O1(17);IWP-O1 >=98% (HPLC);IWP-O1, 10 mM in DMSO;Wnt,IWP-O-1,Porcupine,IWPO1,inhibit,Inhibitor,IWP-O1,IWP O1;1H-1,2,3-Triazole-1-acetamide, 5-phenyl-N-(5-phenyl-2-pyridinyl)-4-(4-pyridinyl)-;2-(5-Phenyl-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl)-N-(5-phenylpyridin-2-yl)acetamide
- CBNumber:
- CB04844916
- Molecular Formula:
- C26H20N6O
- Molecular Weight:
- 432.48
- MDL Number:
- MOL File:
- 2074607-48-8.mol
| Product description | Number | Pack Size | Price |
| IWP-O1 99.15% | CS-0020521 | 5mg | $120 |
| IWP-O1 99.15% | CS-0020521 | 10mg | $210 |
| IWP-O1 99.15% | CS-0020521 | 25mg | $450 |
| IWP-O1 95.00% | INB0009825 | 5MG | $451.59 |
| IWP-O1 99.15% | CS-0020521 | 50mg | $810 |
| storage temp. | 2-8°C(protect from light) |
|---|---|
| solubility | DMSO : 125 mg/mL (289.03 mM);Water : < 0.1 mg/mL (insoluble) |
| form | Solid |
| color | Light yellow to yellow |
| InChIKey | GYYDQHBKIHQHEB-UHFFFAOYSA-N |
| SMILES | [n]3(nnc(c3c5ccccc5)c4ccncc4)CC(=O)Nc1ncc(cc1)c2ccccc2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
IWP-O1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0020521 | IWP-O1 99.15% | 2074607-48-8 | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0020521 | IWP-O1 99.15% | 2074607-48-8 | 10mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-0020521 | IWP-O1 99.15% | 2074607-48-8 | 25mg | $450 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0009825 | IWP-O1 95.00% | 2074607-48-8 | 5MG | $451.59 | 2021-12-16 | Buy |
| ChemScene | CS-0020521 | IWP-O1 99.15% | 2074607-48-8 | 50mg | $810 | 2021-12-16 | Buy |
IWP-O1 Chemical Properties,Uses,Production
Uses
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells[1].
Biological Activity
IWP-O1 is a porcn inhibitor with an EC50 of 80 pM in a Wnt signaling reporter assay in cultured cells. It can effectively inhibit the phosphorylation of Dvl2/3 in Hela cells.
in vitro
IWP-O1 has good metabolic stability.
target
| Target | Value |
| porcn (Cell-based assay) | 80 pM(EC50) |
References
[1] You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. DOI:10.1016/j.bmcl.2016.11.012
IWP-O1 Preparation Products And Raw materials
Raw materials
Preparation Products
IWP-O1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7778 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4800 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 983 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
