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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide structure

CAS No.: 72811-73-5

Chemical Name:: 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

Synonyms: BM 960102;Torsemide Imp B;TORSEMIDE EP IMP B;4-(3'-Methylphenyl)a;TorseMide IMpurity B;SPECS AJ-333/25006115;Torasemide intermediate;Torsemide EP Impurity B;Torasemide EP Impurity B;Torasemide impurity B (EP)

CBNumber:: CB0486466

Molecular Formula:: C12H13N3O2S

Molecular Weight:: 263.32

MDL Number:: MFCD00661332

MOL File:: 72811-73-5.mol

MSDS File:: SDS

Last updated:2026-05-12 09:16:39

Product description	Number	Pack Size	Price
Torsemide Related Compound A pharmaceutical secondary standard, certified reference material	PHR3145	50mg	$593
Torsemide Related Compound A United States Pharmacopeia (USP) Reference Standard	1672315	75mg	$1510
Torsemide Related Compound A pharmaceutical secondary standard, certified reference material	PHR3145	150MG	$466
4-(m-Tolylamino)pyridine-3-sulfonamide >98.0%(HPLC)(T)	T3007	5g	$102
4-(m-Tolylamino)pyridine-3-sulfonamide >98.0%(HPLC)(T)	T3007	25g	$834
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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Properties

Melting point	162-164C
Boiling point	475.8±55.0 °C(Predicted)
Density	1.357±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.53±0.60(Predicted)
color	White to Off-White
BRN	5438165
Major Application	pharmaceutical (small molecule)
InChI	InChI=1S/C12H13N3O2S/c1-9-3-2-4-10(7-9)15-11-5-6-14-8-12(11)18(13,16)17/h2-8H,1H3,(H,14,15)(H2,13,16,17)
InChIKey	ZXPCUGWAKUIOOF-UHFFFAOYSA-N
SMILES	C1=NC=CC(NC2=CC=CC(C)=C2)=C1S(N)(=O)=O
CAS DataBase Reference	72811-73-5(CAS DataBase Reference)
FDA UNII	7GN70NEN27
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P305+P351+P338
Hazard Codes	Xi
Risk Statements	36
Safety Statements	26
WGK Germany	WGK 3
HS Code	2935909550
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2
REACH Registrations	Active

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3145	Torsemide Related Compound A pharmaceutical secondary standard, certified reference material	72811-73-5	50mg	$593	2026-04-30	Buy
Sigma-Aldrich	1672315	Torsemide Related Compound A United States Pharmacopeia (USP) Reference Standard	72811-73-5	75mg	$1510	2026-04-30	Buy
Sigma-Aldrich	PHR3145	Torsemide Related Compound A pharmaceutical secondary standard, certified reference material	72811-73-5	150MG	$466	2022-05-15	Buy
TCI Chemical	T3007	4-(m-Tolylamino)pyridine-3-sulfonamide >98.0%(HPLC)(T)	72811-73-5	5g	$102	2026-04-30	Buy
TCI Chemical	T3007	4-(m-Tolylamino)pyridine-3-sulfonamide >98.0%(HPLC)(T)	72811-73-5	25g	$834	2021-12-16	Buy

Product number	Packaging	Price	Buy
PHR3145	50mg	$593	Buy
1672315	75mg	$1510	Buy
PHR3145	150MG	$466	Buy
T3007	5g	$102	Buy
T3007	25g	$834	Buy

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

Torasemide intermediate.

Synthesis

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide is prepared by the reaction of 4-Chloropyridine-3-sulfonamide hydrochloride and 3-Methylaniline. The specific synthesis steps are as follows:
EXAMPLE 1; Preparation of 4-(3-methylphenyl)aminopyridine-sulfonamide; 2L three-neck flask, equipped with a mechanical stirrer, thermometer and condenser, was charged with water (500 ml) and 4-chloro-3- pyridinesulfonamide hydrochloride (100g, 0.44 mol). To this suspension was added m-toluidine (49.2 ml, 0.46 mol) at room temperature. The reaction mixture was heated to 90°C for a minimum period of 3 h. The progress of the reaction was followed by HPLC. After completion, the mixture was cooled to room temperature. The pH of the reaction was then adjusted carefully to pH 7-8 with sat. NaHC03 (ca. 1.1 l). The product was precipitated out and isolated by vacuum filtration as beige solid (126.2 g wet weight). The product was then dissolved in MeOH (1.0 l) at room temperature and charged with Darco KB (25g). The solution was refluxed for 0.5 h and then filtered through a patch of celite to remove Darco KB, while still hot, and rinsed with hot MeOH (200 ML). The filtrate was then charged with water (1.2 l) and stirred for a minimum of 1 h at room temperature. The product, which had precipitated out, was isolated by vacuum filtration to obtain a solid 106.3 g (92percent wet weight =>99.8percent purity a/a). 1H NMR (d6-DMSO) ; 2.30 (s, 3H), 7.00-7. 15 (m. 5H), 7.32 (m, 1H), 7.75 (brs, 1.5H), 8.05 (brs, 0.5H), 8.25 (d, 1H), 8.68 (s, 1H).
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide synthesis

References

[1] Patent: WO2004/89904, 2004, A2. Location in patent: Page 7

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide synthesis

Synthesis of 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide from 4-Chloro-3-pyridinesulfonamide hydrochloride,98% and m-Toluidine

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Preparation Products And Raw materials

Raw materials

4-Amino-3-pyridinesulfonamide 4-Chloro-3-pyridinesulfonamide hydrochloride,98% 4-Chloro-3-pyridinesulfonamide 3-Iodotoluene m-Toluidine

Sodium bicarbonate

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Preparation Products

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Suppliers

Global( 342)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hebei Zhanyao Biotechnology Co. Ltd	15369953316 +8615369953316	admin@zhanyaobio.com	China	2123	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hebei Zhanyao Biotechnology Co. Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-01	4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 72811-73-5	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-06-25	4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 72811-73-5	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2021-11-19	4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 72811-73-5	US $10.00 / Kg/Bag	1Kg/Bag	99%	20 Tons	Hebei Zhanyao Biotechnology Co. Ltd

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
US $10.00 / Kg/Bag
99%
Hebei Zhanyao Biotechnology Co. Ltd

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Spectrum

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide(72811-73-5)¹HNMR

72811-73-5(4-(3'-Methylphenyl)amino-3-pyridinesulfonamide)Related Search:

Torasemide Impurity 4-CHLORO-3-PYRIDINESULFONIC ACID 2-Pyridinesulfonamide,4-chloro-(9CI) 4-Hydroxypyridine-3-sulfonic acid 4-Chloro-3-Pyridine-sulfonyl-chloride

Torsemide Related Compound 1 [[4-[(3-Methylphenyl)aMino]-3-pyridinyl]sulfonyl]carbaMic Acid Ethyl Ester Torsemide Impurity E 1-Ethyl-3-[[4-(m-toluidino)-3-pyridyl]sulfonyl]urea N-[(n-butylaMino)carbonyl]-4-[(3-Methylphenyl)aMino]-3-pyridinesulfonaMide

Torasemide 4-(3-Methylphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazin-3(4H)-one 1,1-Dioxide N-[[(1-Methylethyl-d7)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide 3-Pyridinesulfonamide Sulfamide

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Galosemide TORSEMIDE RELATED COMPOUND A (75 MG) (4-[(3-METHYLPHENYL)AMINO]-3-PYRIDINESULFONAMIDE)

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Standard for Torasemide Impurity Torasemide Impurity 2（Torasemide EP Impurity B） Torasemide EP Impurity B Torasemide impurity B (EP) 4-[(3-Methylphenyl)amino]-pyridin-3-sulfonamide 4-(-3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE 3-SULFONAMIDO-4-(3-METHYLANILINO)-PYRIDINE SPECS AJ-333/25006115 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE (SMPAP) 4-[3-Methyl phenyl] amino-3-pyridine sulphonamide Torasemide intermediate [4-(3-Methylphenyl)amino]pyrid 4-(3-methylphenyl)amino-3-pyridine sulfonamide (intermediate of torasemide) 4-(3-methylphenylamino) Pyridine-3-sulfonamide [4-3-Methylphenyl)amino]pyridine-3-sulphonamide 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE 98% 4-(3'-Methylphenyl)a TorseMide Related CoMpound A BM 960102 4-(M-TolylaMino)pyridine-3-sulfonaMide TorseMide IMpurity B Torsemide USP Related Compound A Torasemi Impurity B Standard 4[(3-Methyl Phenyl) amino] 3-Pyridine Sulfonamide (Torsamide Intermediate) (72811-73-5) 4-[(3-Methylphenyl)amino]pyridine-3 Torsemide EP Impurity B 3-Pyridinesulfonamide, 4-[(3-methylphenyl)amino]- 4-(3-Methylphenyl)amino-3-sulfamoylpyridine 4-(m-Tolylamino)-3-sulfamoylpyridine 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide ISO 9001：2015 REACH Torsemide EP Impurity B/ Torsemide Related Compound A Torsemide Impurity BQ: What is Torsemide Impurity B Q: What is the CAS Number of Torsemide Impurity B Q: What is the storage condition of Torsemide Impurity B Q: What are the applications of Torsemide Impurity B TIANFU-CHEM_high purity of 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Torasemide, Anhydrous Impurity B Torasemide, Anhydrous EP Impurity B 4-(3-methylanilinopyridine)-3-sulfonamide 4-(3-Methylphenyl)Amino-3-Pyridinesulfonamide (Torsemide Intermediate) Torsemide Imp B 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide TORSEMIDE EP IMP B Torasemide (Torsemide) EP Impurity B (Torasemide (Torsemide) USP Related Compound A) 4-[(3-Methylphenyl)amino]-3-pyridinesulfomide 4-(m-Tolylamino)pyridine-3-sulfonamide (Torasemide Impurity) 72811-73-5 C12H13N3O2S Aromatics Intermediates & Fine Chemicals Pharmaceuticals INTERMEDIATESOFTORASEMIDE Pyridines derivates (intermediate of torasemide) Pyridines Torsemide 72811-73-5