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Paricalcitol

Paricalcitol structure

CAS No.: 131918-61-1

Chemical Name:: Paricalcitol

Synonyms: Zemplar;CS-1390;Zemplarr;PARICALCITOL;Paricalciferol;D6-Paricalcitol;Paricalcitol, >=98%;Paricalcitol(Zemplar);19-Nor-1,25- dihydroxyvitaMin D2;1α,25-Dihydroxy-19-nor-vitaMin D2

CBNumber:: CB0500520

Molecular Formula:: C27H44O3

Molecular Weight:: 416.65

MDL Number:

MOL File:: 131918-61-1.mol

MSDS File:: SDS

Last updated:2026-03-13 23:13:44

Product description	Number	Pack Size	Price
Paricalcitol	1499414	3ml	$924
Paricalcitol	1499403	10mg	$3910
Paricalcitol ≥98%	17716	500μg	$98
Paricalcitol ≥98%	17716	1mg	$186
Paricalcitol ≥98%	17716	5mg	$778
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Paricalcitol Properties

Boiling point	564.8±50.0 °C(Predicted)
Density	1.121±0.06 g/cm3(Predicted)
Flash point	14℃
storage temp.	Store at -20°C,unstable in solution, ready to use.
solubility	DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form	Solid
pka	14.34±0.40(Predicted)
color	White to off-white
InChIKey	BPKAHTKRCLCHEA-UBFJEZKGSA-N
SMILES	C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C \|&1:1,10,13,16,20,22,26,r\|
CAS DataBase Reference	131918-61-1(CAS DataBase Reference)
FDA UNII	6702D36OG5
NCI Dictionary of Cancer Terms	paricalcitol
NCI Drug Dictionary	paricalcitol
ATC code	H05BX02
UNSPSC Code	41116107
NACRES	NA.77

Pharmacokinetic data

Protein binding	>99%
Excreted unchanged in urine	0 (16% as metabolites)
Volume of distribution	17-25 Litres (6 Litres in haemodialysis patients)
Biological half-life	15 (oral 5-7) / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301+H311-H330-H372

Precautionary statements

P280-P301+P310+P330-P302+P352+P312-P304+P340+P310-P314

RIDADR

UN1170 - class 3 - PG 2 - Ethanol, solution

WGK Germany

WGK 3

HS Code

2936299055

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 2 Inhalation
Acute Tox. 3 Dermal
Acute Tox. 3 Oral
STOT RE 1 Oral

Hazardous Substances Data

131918-61-1(Hazardous Substances Data)

NFPA 704

	0
4		0

Paricalcitol price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1499414	Paricalcitol	131918-61-1	3ml	$924	2025-07-31	Buy
Sigma-Aldrich	1499403	Paricalcitol	131918-61-1	10mg	$3910	2025-07-31	Buy
Cayman Chemical	17716	Paricalcitol ≥98%	131918-61-1	500μg	$98	2024-03-01	Buy
Cayman Chemical	17716	Paricalcitol ≥98%	131918-61-1	1mg	$186	2024-03-01	Buy
Cayman Chemical	17716	Paricalcitol ≥98%	131918-61-1	5mg	$778	2024-03-01	Buy

Product number	Packaging	Price	Buy
1499414	3ml	$924	Buy
1499403	10mg	$3910	Buy
17716	500μg	$98	Buy
17716	1mg	$186	Buy
17716	5mg	$778	Buy

Paricalcitol Chemical Properties,Uses,Production

Description

Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.

Description

Paricalcitol is a synthetic 1,25-dihydroxy vitamin D₂ analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.

Chemical Properties

White Solid

Originator

Abbott (US)

Uses

Antihyperparathyriod

Uses

1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.

Uses

Synthetic analog of vitamin D. Antihyperparathyroid.

Definition

ChEBI: Paricalcitol is a seco-cholestane and a hydroxy seco-steroid. It has a role as an antiparathyroid drug. It is functionally related to a vitamin D2.

brand name

Zemplar (Abbott).

Clinical Use

Vitamin D analogue:
Treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure

Metabolism

Extensively metabolised via hepatic and non-hepatic pathways to form two relatively inactive metabolites. After oral administration of 3 H-paricalcitol, only about 2% of the dose was eliminated unchanged in the faeces, and no parent drug found in the urine.
Approximately 70% of the radioactivity was eliminated in the faeces and 18% was recovered in the urine. Most of the systemic exposure was from the parent drug.

References

[1] ALEX J BROWN. Calcemic activity of 19-Nor-1,25(OH)(2)D(2) decreases with duration of treatment.[J]. Journal of The American Society of Nephrology, 2000, 11 11: 2088-2094. DOI: 10.1681/asn.v11112088
[2] JAVIER DONATE-CORREA. Beneficial effects of selective vitamin D receptor activation by paricalcitol in chronic kidney disease.[J]. Current drug targets, 2014, 15 7: 703-709. DOI: 10.2174/1389450115666140417120902
[3] MYLES WOLF Ravi T. Vitamin D in patients with renal failure: A summary of observational mortality studies and steps moving forward[J]. Journal of Steroid Biochemistry and Molecular Biology, 2007, 103 3: Pages 487-490. DOI: 10.1016/j.jsbmb.2006.11.009
[4] DARKO DUPLANCIC. The influence of selective vitamin D receptor activator paricalcitol on cardiovascular system and cardiorenal protection.[J]. Clinical Interventions in Aging, 2013, 8: 149-156. DOI: 10.2147/cia.s38349

Paricalcitol Preparation Products And Raw materials

Raw materials

Preparation Products

Paricalcitol Suppliers

Global( 293)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
HangZhou RunYan Pharma Technology Co.,LTD.	+8618882027439	sales2@runyanpharma.com	China	302	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13822	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21595	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58

Supplier	Advantage
airuikechemical co., ltd.	58
HangZhou RunYan Pharma Technology Co.,LTD.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
Biochempartner	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58

View Lastest Price from Paricalcitol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-13	Paricalcitol 131918-61-1	US $147.00-745.00 / mg		99.84%	10g	TargetMol Chemicals Inc.
2025-08-21	Paricalcitol 131918-61-1	US $0.00-0.00 / g	1g	99.0%min. HPLC	10000	HangZhou RunYan Pharma Technology Co.,LTD.
2024-12-24	Paricalcitol 131918-61-1	US $0.00-0.00 / Kg	1Kg	99.9%	20tons	airuikechemical co., ltd.

Paricalcitol
131918-61-1
US $147.00-745.00 / mg
99.84%
TargetMol Chemicals Inc.

Paricalcitol
131918-61-1
US $0.00-0.00 / g
99.0%min. HPLC
HangZhou RunYan Pharma Technology Co.,LTD.

Paricalcitol
131918-61-1
US $0.00-0.00 / Kg
99.9%
airuikechemical co., ltd.

Paricalcitol Spectrum

Paricalcitol(131918-61-1)¹HNMR

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Paricalcitol Solution Paricalcitol 1(ALPHA) 25-DIHYDROXYVITAMIN D2*

1of4

CS-1390 PARICALCITOL (10 MG)F0E3030.997MG/MG(AI) PARICALCITOL 19-nor-1alpha,25-dihydroxyvitamin D2 (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol Zemplar 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)- Paricalcitol, >=98% 1,25-DihydroxyvitaMin D2 Paricalcitol Paricalcitol(Zemplar) Paricalcitol (10 mg) (COLD SHIPMENT REQUIRED) (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-Octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-triMethyl-2-hexen-1-yl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol (1α,3β,7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol 19-Nor-1,25- dihydroxyvitaMin D2 1α,25-Dihydroxy-19-nor-vitaMin D2 Paricalcitol/ 19-nor-1α,25-dihydroxyergocalciferol (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-6-hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)cyclohexane-1,3-diol ParicalcitolQ: What is Paricalcitol Q: What is the CAS Number of Paricalcitol Q: What is the storage condition of Paricalcitol Q: What are the applications of Paricalcitol Paricalcitol (COLD SHIPMENT REQUIRED) (1499403) (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)cyclohexane-1,3-diol Paricalciferol Zemplarr (1R,3R)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R,3E,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}cyclohexane-1,3-diol D6-Paricalcitol 131918-61-1 131919-61-1 Vitamin D3 analogs Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals 131918-61-1