(R)-1-CBZ-3-PYRROLIDINOL
- CAS No.
- 100858-33-1
- Chemical Name:
- (R)-1-CBZ-3-PYRROLIDINOL
- Synonyms
- Benzyl (R)-3-hydroxypyrrolidine-1-carboxylate;(R)-(-)-1-Cbz-3-pyrroL;(R)-1-Cbzl-3-pyrrolidinol;(3R)-N-CBZ-3-pyrrolidinol;(R)-(-)-1-Cbz-3-pyrrolidinol;(R)-N-Cbz-3-hydroxypyrroline;N-Cbz-3(R)-hydroxypyrrolidine;R-1-N-CBZ-3- hydroxy-pyrroline;(R)-N-Cbz-3-hydroxypyrrolidine;(R)-1-Cbz-3-pyrrolidinol, ee: 98%
- CBNumber:
- CB0505444
- Molecular Formula:
- C12H15NO3
- Molecular Weight:
- 221.25
- MDL Number:
- MFCD07368258
- MOL File:
- 100858-33-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (R)-(?)-1-Cbz-3-pyrrolidinol 95% | 654655 | 5g | $367 |
| (R)-(?)-1-Cbz-3-pyrrolidinol 95% | 654655 | 1g | $75.1 |
| (R)-1-Carbobenzoxy-3-pyrrolidinol >98.0%(GC) | C2585 | 1g | $32 |
| (R)-1-Carbobenzoxy-3-pyrrolidinol >98.0%(GC) | C2585 | 5g | $155 |
| (R)-(-)-1-CBZ-3-HYDROXY-PYRROLIDINE 97% | 57610 | 5G | $32 |
| More product size | |||
| Melting point | 74-79 °C |
|---|---|
| Boiling point | 370.7±42.0 °C(Predicted) |
| Density | 1.263±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Chloroform |
| form | powder to crystal |
| pka | 14.72±0.20(Predicted) |
| color | Light orange to Yellow to Green |
| InChI | InChI=1S/C12H15NO3/c14-11-6-7-13(8-11)12(15)16-9-10-4-2-1-3-5-10/h1-5,11,14H,6-9H2/t11-/m1/s1 |
| InChIKey | MBLJFGOKYTZKMH-LLVKDONJSA-N |
| SMILES | N1(C(OCC2=CC=CC=C2)=O)CC[C@@H](O)C1 |
| CAS DataBase Reference | 100858-33-1 |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
(R)-1-CBZ-3-PYRROLIDINOL price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 654655 | (R)-(?)-1-Cbz-3-pyrrolidinol 95% | 100858-33-1 | 5g | $367 | 2026-04-30 | Buy |
| Sigma-Aldrich | 654655 | (R)-(?)-1-Cbz-3-pyrrolidinol 95% | 100858-33-1 | 1g | $75.1 | 2023-06-20 | Buy |
| TCI Chemical | C2585 | (R)-1-Carbobenzoxy-3-pyrrolidinol >98.0%(GC) | 100858-33-1 | 1g | $32 | 2026-04-30 | Buy |
| TCI Chemical | C2585 | (R)-1-Carbobenzoxy-3-pyrrolidinol >98.0%(GC) | 100858-33-1 | 5g | $155 | 2026-04-30 | Buy |
| AstaTech | 57610 | (R)-(-)-1-CBZ-3-HYDROXY-PYRROLIDINE 97% | 100858-33-1 | 5G | $32 | 2026-04-30 | Buy |
(R)-1-CBZ-3-PYRROLIDINOL Chemical Properties,Uses,Production
Chemical Properties
White to brown crystal to powder
Uses
(R)-1-CBZ-3-PYRROLIDINOL is an intermediate in synthesizing Monocrotaline-d4 (M526002), a labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Synthesis
130312-02-6
100858-33-1
General procedure for the synthesis of N-CBZ-3-(R)-hydroxypyrrolidine using N-Cbz-3-pyrrolidone as starting material: a reaction mixture of 1 mL of potassium phosphate buffer (100 mM, pH 7.0) containing 200 mM of substrate, 1 mM NAD+, 5% (v/v) 2-propanol, and 10 mg of crude enzyme READH was warmed at 50 °C. For ChKRED20, the reaction conditions were adjusted to 40% (v/v) 2-propanol and 40°C reaction temperature. The reaction progress was monitored by thin layer chromatography (TLC) and the reaction was terminated by the addition of 1 mL of methyl tert-butyl ether extraction. The organic phase was dried with anhydrous sodium sulfate and concentrated. The conversion and enantiomeric excess were determined by chiral high performance liquid chromatography (HPLC). The products were purified by silica gel column chromatography and structurally characterized by nuclear magnetic resonance (NMR) analysis, spinometry and mass spectrometry (MS).
References
[1] Process Biochemistry, 2017, vol. 56, p. 90 - 97
(R)-1-CBZ-3-PYRROLIDINOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8741 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
View Lastest Price from (R)-1-CBZ-3-PYRROLIDINOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | (R)-1-CBZ-3-PYRROLIDINOL
100858-33-1
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | (R)-1-CBZ-3-PYRROLIDINOL
100858-33-1
|
$1.00 | 1kg | 99% | Career Henan Chemical Co |
-
- (R)-1-CBZ-3-PYRROLIDINOL
100858-33-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (R)-1-CBZ-3-PYRROLIDINOL
100858-33-1
- $1.00
- 99%
- Career Henan Chemical Co
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