HDAC2 antibody

Source

Rabbit

Applications

HDAC2 antibody has been tested by ELISA, Western blot analysis, ICC/IF and Flow cytometry to assure specificity and reactivity.

Reactivity

Human;Mouse;Rat;Monkey

Immunogen

Anti-human HDAC2 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HDAC2 amino acids 1-488 purified from E. coli.

Background

HDAC2 is a member of the histone deacetylase family that performs through the construction of large multiprotein complexes and are in charge of the deacetylation of lysine residues on the N-terminal region of the core histones. HDAC2 forms transcriptional repressor complexes by relating to a diversity of proteins, like YY1- a mammalian zinc-finger transcription factor. 
In addition, HDAC2 has a vital part in transcriptional regulation, cell cycle progression and developmental procedures.

References

[1] Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703.
[2] Gregory, P.D. et al. (2001) Exp Cell Res 265, 195-202.
[3] Liu, Y. et al. (2000) Mol Cell Biol 20, 5540-53.
[4] Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16.
[5] Gray, S.G. and Ekström, T.J. (2001) Exp Cell Res 262, 75-83.
[6] Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100.
[7] Vigushin, D.M. and Coombes, R.C. (2004) Curr Cancer Drug Targets 4, 205-18.
[8] Zhang, Y. et al. (1999) Genes Dev. 13, 1924-1935.
[9] Ng, H.H. et al. (1999) Nat. Genet. 23, 58-61.
[10] Zhang, Y. et al. (1997) Cell 89, 357-364.

Raw materials

Preparation Products