MCAM Antibody
- CAS No.
- Chemical Name:
- MCAM Antibody
- Synonyms
- MCAM Antibody;Rabbit Polyclonal MCAM Antibody
- CBNumber:
- CB05653348
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
MCAM Antibody Chemical Properties, Uses, Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
Melanoma cell adhesion molecule is an immunoglobulin superfamily member originally described as a cell surface adhesion protein and marker of the progression and metastasis of melanoma. Expression of MCAM protein is seen in vascular endothelial cells, activated T lymphocytes, smooth muscle, and bone marrow stromal cells. Research studies demonstrate increased MCAM expression in endothelial cells from angiogenesis-related disorders, including inflammatory bowel disease, Crohn’s disease, rheumatoid arthritis, tumors, and chronic renal failure. MCAM-expressing human mesenchymal stromal cells in the hematopoietic microenvironment are responsible for maintaining the self-renewal of hematopoietic stem and progenitor cells through direct contact between hMSC and HSPC. Related studies suggest that activation of the Notch signaling pathway may also, in part, play a role in HSPC maintenance. Additional research indicates that MCAM may play a role in multiple sclerosis, an autoimmune inflammatory disease that affects central nervous system neurons. Endothelial MCAM within the blood-brain barrier act as adhesion receptors that permit lymphocytes to transmigrate across the barrier and produce the inflammatory lesions that characterize the disorder.
References
[1] Shih, I.M. (1999) J Pathol 189, 4-11.
[2] Stopp, S. et al. (2013) Haematologica 98, 505-13.
[3] Wang, P. et al. (2013) Mol Cell Biol 33, 3689-99.
[4] Corselli, M. et al. (2013) Blood 121, 2891-901.
[5] Duan, H. et al. (2013) Sci Rep 3, 1687.
MCAM Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
MCAM Antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Serenity BioSolutions Co., Ltd. | 027-19371278702 18008634902 | 19384116026@163.com | China | 3008 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Serenity BioSolutions Co., Ltd. | 58 |
