SIRT6 antibody
- CAS No.
- Chemical Name:
- SIRT6 antibody
- Synonyms
- SIRT6 antibody
- CBNumber:
- CB05696028
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
SIRT6 antibody price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb622002 | SIRT6 Antibody | 50μl | $400 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb622002 | SIRT6 Antibody | 100μl | $540 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb379202 | SIRT6 antibody Peptide affinity purified | 100μL | $399.5 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb6960 | SIRT6 antibody Affinity purified by Protein A | 100μg | $402.9 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb178238 | SIRT6 antibody Antigen Affinity Purified | 100μg | $425 | 2021-12-16 | Buy |
SIRT6 antibody Chemical Properties, Uses, Production
Source
Rabbit
Reactivity
Human
Background
The Silent Information Regulator family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of this family is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway.
References
[1] Guarente, L. (1999) Nat Genet 23, 281-5.
[2] Mostoslavsky, R. et al. (2006) Cell 124, 315-29.
[3] Liszt, G. et al. (2005) J Biol Chem 280, 21313-20.
[4] Michishita, E. et al. (2005) Mol Biol Cell 16, 4623-35.
SIRT6 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
SIRT6 antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
