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2,6-DIFLUORO-3-NITROBENZOIC ACID

2,6-DIFLUORO-3-NITROBENZOIC ACID structure

CAS No.: 83141-10-0

Chemical Name:: 2,6-DIFLUORO-3-NITROBENZOIC ACID

Synonyms: RARECHEM AL BO 0441;2,6-Difluro-3-nitrobenzoic acid;2,6-DIFLUORO-3-NITROBENZOIC ACID;2,6-Difluoro-3-nitrobenzoicacid98%;3-Carboxy-2,4-difluoronitrobenzene;Benzoic acid, 2,6-difluoro-3-nitro-;2,6-Difluoro-3-nitrobenzoic acid 98%;2,6-DIFLUORO-3-NITROBENZOIC ACID ISO 9001：2015 REACH;Benzoic acid,2,6-difluoro-3-nitro- (Related Reference)

CBNumber:: CB0676032

Molecular Formula:: C7H3F2NO4

Molecular Weight:: 203.1

MDL Number:: MFCD00119291

MOL File:: 83141-10-0.mol

Last updated:2025-07-24 18:13:49

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2,6-DIFLUORO-3-NITROBENZOIC ACID Properties

Melting point	92-96°C
Boiling point	335.5±42.0 °C(Predicted)
Density	1.661
storage temp.	Sealed in dry,Room Temperature
pka	1.48±0.29(Predicted)
form	powder to crystal
color	White to Light yellow
InChI	InChI=1S/C7H3F2NO4/c8-3-1-2-4(10(13)14)6(9)5(3)7(11)12/h1-2H,(H,11,12)
InChIKey	PDDHSNODMFIIRV-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=C(F)C=CC([N+]([O-])=O)=C1F
CAS DataBase Reference	83141-10-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39-24/25

Hazard Note

Irritant/Keep Cold

HazardClass

IRRITANT

HS Code

29163990

NFPA 704

	0
2		0

2,6-DIFLUORO-3-NITROBENZOIC ACID price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D5138	2,6-Difluoro-3-nitrobenzoic Acid >98.0%(GC)(T)	83141-10-0	5g	$66	2025-07-31	Buy
TCI Chemical	D5138	2,6-Difluoro-3-nitrobenzoic Acid >98.0%(GC)(T)	83141-10-0	25g	$260	2025-07-31	Buy
TRC	D447138	2,6-Difluoro-3-nitrobenzoic Acid	83141-10-0	1g	$75	2021-12-16	Buy
TRC	D447138	2,6-Difluoro-3-nitrobenzoic Acid	83141-10-0	500mg	$65	2021-12-16	Buy
TRC	D447138	2,6-Difluoro-3-nitrobenzoic Acid	83141-10-0	100mg	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
D5138	5g	$66	Buy
D5138	25g	$260	Buy
D447138	1g	$75	Buy
D447138	500mg	$65	Buy
D447138	100mg	$45	Buy

2,6-DIFLUORO-3-NITROBENZOIC ACID Chemical Properties,Uses,Production

Chemical Properties

Light yellow solid

Uses

2,6-Difluoro-3-nitrobenzoic acid is a benzoic acid derivative that contains reactive substituent fluorine atoms and nitro groups in its molecular structure. The substance is mainly used as a reagent for organic synthesis or as a component of pharmaceutical intermediates. It is used in the synthesis of B-Raf kinase inhibitors, such as vemurafenib, which causes programmed cell death (apoptosis) in melanoma cell lines. In addition, it is used in the synthesis of fluoroquinolone antibacterial agents.

Synthesis

385-00-2

83141-10-0

General procedure for the synthesis of 2,6-difluoro-3-nitrobenzoic acid from 2,6-difluorobenzoic acid: Concentrated sulfuric acid (5 mL) was slowly added to 2,6-difluorobenzoic acid (1.4 g, 9 mmol) at 0 °C, followed by gradual addition of potassium nitrate (1 g, 9.9 mmol). After warming the reaction mixture to room temperature, stirring was continued for 24 hours. After completion of the reaction, ice water was poured into the reaction mixture and extracted with ethyl acetate. The organic layer was dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The solid in the concentrated filtrate was washed with ether and dried to give 2,6-difluoro-3-nitrobenzoic acid (1.3 g, yield: 71%). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.37 (td, J = 9.2,5.6 Hz, 1H), 7.46 (t, J = 9.2 Hz, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2647 - 2666
[2] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 10, p. 3530 - 3543
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 10, p. 1905 - 1917
[4] Synlett, 2012, vol. 23, # 7, p. 1039 - 1042
[5] Patent: EP2647637, 2013, A2. Location in patent: Paragraph 0055

2,6-DIFLUORO-3-NITROBENZOIC ACID Preparation Products And Raw materials

Raw materials

2,6-Difluorobenzoic acid

Preparation Products

1-PropanesulfonaMide, N-[3-[[5-broMo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]- CarbaMic acid, (3-aMino-2,6-difluorophenyl)-, 1,1-diMethylethyl ester

2,6-DIFLUORO-3-NITROBENZOIC ACID Suppliers

Global( 170)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20191	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Changzhou PBpharmaceutical R&D Co.,Ltd	0519-83990708	info@pbpharm.com	CHINA	498	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Jinan Carbotang Biotech Co.,Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Changzhou PBpharmaceutical R&D Co.,Ltd	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2,6-DIFLUORO-3-NITROBENZOIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-12-26	2,6-DIFLUORO-3-NITROBENZOIC ACID 83141-10-0	US $100.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2021-08-12	2,6-DIFLUORO-3-NITROBENZOIC ACID 83141-10-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-02-26	2,6-Difluoro-3-nitrobenzoic acid 83141-10-0	US $0.00-0.00 / Kg	1KG	99.0%	100 tons	Shaanxi Dideu Medichem Co. Ltd

2,6-DIFLUORO-3-NITROBENZOIC ACID
83141-10-0
US $100.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

2,6-DIFLUORO-3-NITROBENZOIC ACID
83141-10-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2,6-Difluoro-3-nitrobenzoic acid
83141-10-0
US $0.00-0.00 / Kg
99.0%
Shaanxi Dideu Medichem Co. Ltd

2,6-DIFLUORO-3-NITROBENZOIC ACID Spectrum

2,6-DIFLUORO-3-NITROBENZOIC ACID(83141-10-0)¹HNMR 2,6-DIFLUORO-3-NITROBENZOIC ACID(83141-10-0)¹⁹FNMR 2,6-DIFLUORO-3-NITROBENZOIC ACID(83141-10-0)FT-IR

83141-10-0(2,6-DIFLUORO-3-NITROBENZOIC ACID)Related Search:

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RARECHEM AL BO 0441 2,6-Difluoro-3-nitrobenzoic acid 98% 2,6-Difluoro-3-nitrobenzoicacid98% 2,6-DIFLUORO-3-NITROBENZOIC ACID 2,6-Difluro-3-nitrobenzoic acid Benzoic acid,2,6-difluoro-3-nitro- (Related Reference) 3-Carboxy-2,4-difluoronitrobenzene Benzoic acid, 2,6-difluoro-3-nitro- 2,6-DIFLUORO-3-NITROBENZOIC ACID ISO 9001：2015 REACH 83141-10-0 83141-10-1 Benzene series Benzoic acid NitroCompounds Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts blocks Carboxes FluoroCompounds