4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
- CAS No.
- 6975-44-6
- Chemical Name:
- 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
- Synonyms
- Ethyl 4,6-dihydroxynicotinate;ethyl 2,4-dihydroxypyridine-5-carboxylate;NSC 22486;BUTTPARK 153\57-32;SPECS AC-907/34126052;2,4-Dihydroxy-5-(ethoxycar;4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER;2,4-Dihydroxy-5-(ethoxycarbonyl)pyridine;Ethyl 4,6-Dihydroxypyridine-3-carboxylate;4,6-Dihydroxynicotinic acid ethyl ester ,97%
- CBNumber:
- CB0680790
- Molecular Formula:
- C8H9NO4
- Molecular Weight:
- 183.16
- MDL Number:
- MFCD00834976
- MOL File:
- 6975-44-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl 4,6-Dihydroxynicotinate >97.0%(T) | E1110 | 1g | $57 |
| Ethyl 4,6-Dihydroxynicotinate >97.0%(T) | E1110 | 5g | $174 |
| ETHYL 4,6-DIHYDROXYNICOTINATE 97% | 52358 | 5G | $30 |
| ETHYL 4,6-DIHYDROXYNICOTINATE 97% | 52358 | 25G | $129 |
| Ethyl 4,6-dihydroxynicotinate 98% | E49350 | 1g | $20 |
| More product size | |||
| Melting point | 214-217° |
|---|---|
| Boiling point | 339.4±42.0 °C(Predicted) |
| Density | 1.380 |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 4.50±1.00(Predicted) |
| color | White to Orange to Green |
| InChI | InChI=1S/C8H9NO4/c1-2-13-8(12)5-4-9-7(11)3-6(5)10/h3-4H,2H2,1H3,(H2,9,10,11) |
| InChIKey | QDHHLXABEXNRJX-UHFFFAOYSA-N |
| SMILES | C1NC(=O)C=C(O)C=1C(OCC)=O |
| CAS DataBase Reference | 6975-44-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1110 | Ethyl 4,6-Dihydroxynicotinate >97.0%(T) | 6975-44-6 | 1g | $57 | 2025-07-31 | Buy |
| TCI Chemical | E1110 | Ethyl 4,6-Dihydroxynicotinate >97.0%(T) | 6975-44-6 | 5g | $174 | 2025-07-31 | Buy |
| AstaTech | 52358 | ETHYL 4,6-DIHYDROXYNICOTINATE 97% | 6975-44-6 | 5G | $30 | 2026-04-30 | Buy |
| AstaTech | 52358 | ETHYL 4,6-DIHYDROXYNICOTINATE 97% | 6975-44-6 | 25G | $129 | 2026-04-30 | Buy |
| Synthonix | E49350 | Ethyl 4,6-dihydroxynicotinate 98% | 6975-44-6 | 1g | $20 | 2026-05-06 | Buy |
4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
Ethyl 4,6-dihydroxynicotinate has been used as a reactant is the synthesis of pyridazinopyrimidinone and pyridopyrimidinone derivatives as PDE5 inhibitors and for the synthesis of pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Synthesis
108-24-7
105-50-0
6975-44-6
The general procedure for the synthesis of ethyl 4,6-dihydroxynicotinate from ethanoic anhydride and diethyl 1,3-acetone dicarboxylate was as follows: diethyl 3-oxoglutarate (101 g, 0.5 mol), triethyl orthoformate (81.4 g, 0.55 mol), and acetic anhydride (102 g, 1 mol) were mixed and the reaction was maintained at a temperature of 120 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and dissolved in dichloromethane (1 L). Subsequently, the solution was cooled to 0 °C, 30% ammonia (80 mL) was slowly added, and then the reaction mixture was gradually warmed to room temperature and left overnight. The reaction mixture was extracted twice with water and the aqueous phase was adjusted to pH 5 with concentrated hydrochloric acid. after acidification, the precipitate was collected by filtration to afford ethyl 4,6-dihydroxynicotinate (60.0 g, 60% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.99 (s, 1H), 5.58 (s, 1H), 4.23 (q, J = 6.8, 14.0 Hz, 2H), 1.25 (t, J = 7.2 Hz, 3H); MS (ESI) m/z: 184.1 [M + H]+.
References
[1] Patent: US8461179, 2013, B1. Location in patent: Page/Page column 66
4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9537 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
View Lastest Price from 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
6975-44-6
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
6975-44-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
6975-44-6
|
US $1.00 / kg | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
6975-44-6
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
6975-44-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
6975-44-6
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
6975-44-6(4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER)Related Search:
1of4
