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Thianaphthene

Thianaphthene structure

CAS No.: 95-15-8

Chemical Name:: Thianaphthene

Synonyms: BENZO[B]THIOPHENE;BENZOTHIOPHENE;BBT;BZT;THIONAPHTHENE;1-BENZOTHIOPHENE;Thianapthene;Thionaphthalene;Thiaphthene;ianaphthene

CBNumber:: CB0683988

Molecular Formula:: C8H6S

Molecular Weight:: 134.2

MDL Number:: MFCD00005864

MOL File:: 95-15-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:50:04

Product description	Number	Pack Size	Price
Thianaphthene 98%	357790	5g	$39.7
Thianaphthene 98%	357790	25g	$94.6
Benzo[b]thiophene >97.0%(GC)	B0093	5g	$20
Benzo[b]thiophene >97.0%(GC)	B0093	25g	$57
Thianaphthene Asreported	290607	25g	$322
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Thianaphthene Properties

Melting point	30-33 °C
Boiling point	221-222 °C(lit.)
Density	1.149 g/mL at 25 °C(lit.)
vapor pressure	1.33 hPa ( 20 °C)
refractive index	1.6332 (estimate)
Flash point	>230 °F
storage temp.	Store below +30°C.
solubility	0.13g/l
form	Crystalline Solid
pka	32.4
Specific Gravity	1.149
color	White to pink or yellow
Water Solubility	insoluble
Merck	14,9303
BRN	80580
Henry's Law Constant	4.1×10^-2 mol/(m³Pa) at 25℃, Mackay et al. (1995)
InChI	1S/C8H6S/c1-2-4-8-7(3-1)5-6-9-8/h1-6H
InChIKey	FCEHBMOGCRZNNI-UHFFFAOYSA-N
SMILES	c1ccc2sccc2c1
LogP	3.120
CAS DataBase Reference	95-15-8(CAS DataBase Reference)
FDA UNII	073790YQ2G
NIST Chemistry Reference	Benzo[b]thiophene(95-15-8)
EPA Substance Registry System	Benzo[b]thiophene (95-15-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H412

Precautionary statements

P264-P270-P273-P301+P312-P501

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Xn,Xi,N

Risk Statements

22-36/37/38-20/21/22-51/53

Safety Statements

22-24/25-36-26-61

RIDADR

UN3077

WGK Germany

Autoignition Temperature

510°C

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29349990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Chronic 3

NFPA 704

	1
2		0

Thianaphthene price More Price(107)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	357790	Thianaphthene 98%	95-15-8	5g	$39.7	2026-04-30	Buy
Sigma-Aldrich	357790	Thianaphthene 98%	95-15-8	25g	$94.6	2026-04-30	Buy
TCI Chemical	B0093	Benzo[b]thiophene >97.0%(GC)	95-15-8	5g	$20	2026-04-30	Buy
TCI Chemical	B0093	Benzo[b]thiophene >97.0%(GC)	95-15-8	25g	$57	2026-04-30	Buy
Usbiological	290607	Thianaphthene Asreported	95-15-8	25g	$322	2026-06-03	Buy

Product number	Packaging	Price	Buy
357790	5g	$39.7	Buy
357790	25g	$94.6	Buy
B0093	5g	$20	Buy
B0093	25g	$57	Buy
290607	25g	$322	Buy

Thianaphthene Chemical Properties,Uses,Production

Chemical Properties

WHITE TO RED CRYSTALLINE LOW MELTING SOLID

Uses

Benzo[b]thiophene has application in organic as well as pharmaceutical industry as a component in the synthesis of Raloxifene, a breast cancer therapeutic, or hydrodesulfurization reactions.

Uses

manufacture of pharmaceuticals, thioindigo.

Uses

Benzo[b]thiophene is used in the preparation of 2-thianapthenylphenyllithium, via metalation by n-butyllithium. It is used in organic as well as pharmaceutical industry as a component in the synthesis of raloxifene, a breast cancer therapeutic, or hydrodesulfurization reactions.

Uses

Thianaphthene may be used in the preparation of 2-thianapthenylphenyllithium, via metalation by n-butyllithium.

Application

Thianaphthene may be used in the preparation of 2-thianapthenylphenyllithium, via metalation by n-butyllithium.
Reaction of ethyl diazoacetate with thianaphthene has been reported.

Definition

ChEBI: 1-benzothiophene is a benzothiophene and a member of 1-benzothiophenes.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 2008, 1947 DOI: 10.1021/ja01200a053
Tetrahedron, 27, p. 1253, 1971 DOI: 10.1016/S0040-4020(01)90874-9

General Description

Reaction of ethyl diazoacetate with thianaphthene has been reported.

Purification Methods

1-Benzothiophene has the odour of naphthalene. If the IR spectrum is not very good, then suspend it in a faintly alkaline aqueous solution and steam distil it. Extract the distillate with Et2O, dry the extract (CaCl2), filter, evaporate the solvent and fractionate the residue. The distillate sets solid. The sulfoxide has m 142o, the picrate has m 148-149o (yellow crystals from EtOH) and the styphnate has m 136-137o. [Hansch & Lindwall J Org Chem 10, 381 1945, Meyer & Meyer Chem Ber 52B 1249 1919, Weisgerber & Kruber 53 1551 1920, Iddon & Scrowston Adv Heterocycl Chem 11 177 1970, Beilstein 17/2 V 6.]

Thianaphthene synthesis

Synthesis of Thianaphthene from Thianaphthene-2-carboxylic acid

Thianaphthene Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Acetylacetone Tetrabutylammonium bromide Thiophenol Bromoacetaldehyde diethyl acetal

Sodium borohydride Thiosalicylic acid Aluminum chloride Tetrahydrofuran Bromoacetic acid

Methanol Sodium hydroxide Thionyl chloride Sulfuric acid

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Preparation Products

1-Benzo[b]thiophen-3-yl-2-bromoethan-1-one 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE Raloxifene 2-(1-HYDROXYLAMINOETHYL)-BENZOTHIOPHENE 2-Acetylbenzo[b]thiophene

1-BENZOTHIOPHENE-3-SULFONYL CHLORIDE BENZO[B]THIOPHENE-3-CARBONITRILE Benzothiophene-3-boronic acid 3-Acetylthianaphthene [2-[4-(dihexylamino)-2-methylbenzylidene]benzo[b]thien-3(2H)-ylidene]malononitrile S,S-dioxide

METHYL BENZO[B]THIOPHENE-2-CARBOXYLATE Benzo[b]thien-2-ylboronic acid BENZO[B]THIOPHENE-2-CARBOXALDEHYDE 1-BENZOTHIOPHENE-2-SULFONYL CHLORIDE 1-Benzothiophene-3-carbaldehyde

1-Benzothiophene-3-carboxylic acid Sertaconazole THIANAPHTHENE-2-CARBOXAMIDE 3-Bromo-1-benzothiophene BENZO[B]THIOPHENE-3-ACETIC ACID

Thianaphthene-2-carboxylic acid 1-BENZOTHIOPHENE-3-CARBONYL CHLORIDE BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE

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Thianaphthene Suppliers

Global( 470)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang Free Trade Zone Violet Trade Co., Ltd.	+8618768051816; +8615858061377	jenny@zjviolettech.com	China	113	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5228	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Springchem New Material Technology Co.,Limited	+86-021-62885108 +8613917661608	info@spring-chem.com	China	2068	57
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55

Supplier	Advantage
Zhejiang Free Trade Zone Violet Trade Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Springchem New Material Technology Co.,Limited	57
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

Thianaphthene: A Versatile Chemical Compound
Thianaphthene finds use in research as a starting material for the synthesis of larger, usually bioactive structures.
Oct 22，2024

Synthesis of Benzothiophene
Benzothiophene is constituted by fusion of the benzene ring with the thiophene ring. There are two possible methods of fusion ....
Jan 27，2022

Related Qustion

Ask a question

Q:What drugs contain benzothiophene?jia - Nov 28，2025

A:The benzothiophene skeleton is an important structure in medicinal chemistry, present in key drugs across a variety of therapeutic classes, most notably the anti-estrogenic drug raloxifene. Raloxifene is a selective estrogen receptor modulator (SERM) primarily used for the prevention and treatment of osteoporosis in postmenopausal women. Besides raloxifene, the benzothiophene moiety is also a component of the anti-asthmatic drug zisulphone (a leukotriene synthesis inhibitor) and the antifungal drug sertaconazole, demonstrating the structural diversity of this sulfur-containing heterocyclic compound in designing compounds with broad biological activities.

View Lastest Price from Thianaphthene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-06	Thianaphthene 95-15-8			0.99		RongNa Biotechnology Co.,Ltd
2026-05-28	Thianaphthene 95-15-8	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-05-19	Thianaphthene 95-15-8			99.89%	10	Zhejiang Free Trade Zone Violet Trade Co., Ltd.

Thianaphthene
95-15-8
0.99
RongNa Biotechnology Co.,Ltd

Thianaphthene
95-15-8
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

Thianaphthene
95-15-8
$0.00
99.89%
Zhejiang Free Trade Zone Violet Trade Co., Ltd.

Thianaphthene Spectrum

Thianaphthene(95-15-8)MS Thianaphthene(95-15-8)¹HNMR Thianaphthene(95-15-8)¹³CNMR Thianaphthene(95-15-8)IR1 Thianaphthene(95-15-8)IR2 Thianaphthene(95-15-8)IR3 Thianaphthene(95-15-8)Raman

95-15-8(Thianaphthene)Related Search:

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Tetrahydrothiophene Brexpiprazole-d8 4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butan-1-ol Brexpiprazole Impurity 20 Brexpiprazole Impurity 36

Brexpiprazole Impurity 5 HCl Brexpiprazole Impurity 2 7-(4-chlorobutoxy)-1-{4-[(2-oxo-1,2-dihydroquinolin-7-yl)oxy]butyl}-1,2-dihydroquinolin-2-one Brexpiprazole Impurity 7 Brexpiprazole Impurity 18

Brexpiprazole Impurity 24 Brexpiprazole Impurity 22 (E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE

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THIANAPHTHENE 2,3-BENZOTHIOPHENE BENZO2,3THIOPHENE Thianaphthene, 97% 5GR 1-BENZOTHIOPHEN Thionaphthene Thianaphthene Thianaphthene, 1-Benzothiophene substituted benzothiophene derivative Thiaphthene Brexpiprazole Impurity 21, Benzo[b]thiophene Thianaphthene, 98+% BenzoÄbÜthiophene,98+% Benzo[b]thiophene 97% 2,3-BENZTHIOPHENE 1-Thiaindene Benzo(beta)thiophene Benzothiofuran Benzothiophen Thianaphtene Thianaphthen Thionaphthen Benzo[b]thiophene, 98+% Thianaphthene, Thionaphthene Benzo[b]thiophene, Benzothiophene, Thionaphthene Benzobüthiophene, 98+% Thiocoumarone Thianaphthene,97% Thianaphthene, 97% 25GR Thianaphthene@50 μg/mL in Toluene Benzo[b]thiophene > Thianaphthene, 98%, for synthesis 1-BENZOTHIOPHENE FOR SYNTHESIS Thianaphthene ISO 9001：2015 REACH Brexpiprazole Impurity 95 Benzo[b]thiophene, ≥ 97.0% ianaphthene Benzothiophene in isooctane Brexpiprazole Dimer Impurity 95 Thianaftene THIONAPHTHENE BBT Compound PDK0416 1-BENZOTHIOPHENE BENZO[B]THIOPHENE BENZOTHIOPHENE BZT Thionaphthalene Thianapthene 95-15-8 C8H6S1 C6H4CHCHS 95158 C8H6S Building Blocks Benzothiophenes Heterocyclic Building Blocks Heterocycle-oher series Benzothiophenes

Thianaphthene

Thianaphthene Properties

SAFETY

Risk and Safety Statements

Thianaphthene price More Price(107)

Thianaphthene Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Uses

Uses

Application

Definition

Synthesis Reference(s)

General Description

Purification Methods

Thianaphthene synthesis

Thianaphthene Preparation Products And Raw materials

Raw materials

Preparation Products

Thianaphthene Suppliers

Related articles

Related Qustion

View Lastest Price from Thianaphthene manufacturers

Thianaphthene Spectrum

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