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4-Cyanopyridine

4-Cyanopyridine Structure
4-Cyanopyridine structure
CAS No.
100-48-1
Chemical Name:
4-Cyanopyridine
Synonyms
ISONICOTINONITRILE;4-PYRIDINECARBONITRILE;Pyridine-4-carbonitrile;4-cyanopyridin;4-CYANOPYRIDINE;Cyanopyridine,4-;AKOS BBS-00004486;4-Pyridinenitrile;Isonicotinonitril;TIMTEC-BB SBB008923
CBNumber:
CB0688145
Molecular Formula:
C6H4N2
Molecular Weight:
104.11
MDL Number:
MFCD00006417
MOL File:
100-48-1.mol
MSDS File:
SDS
Last updated:2026-01-13 11:13:24
Product description Number Pack Size Price
4-Pyridinecarbonitrile 98% C95005 100g $25.5
4-Cyanopyridine >98.0%(GC)(T) C0457 25g $16
4-Cyanopyridine >98.0%(GC)(T) C0457 100g $32
4-Cyanopyridine >98.0%(GC)(T) C0457 500g $105
4-Cyanopyridine C982225 50g $85
More product size
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4-Cyanopyridine Properties

Melting point 76-79 °C(lit.)
Boiling point 196 °C
Density 1.1145 (rough estimate)
vapor pressure 41.9Pa at 25℃
refractive index 1.5242 (estimate)
Flash point 88 °C
storage temp. Sealed in dry,Room Temperature
solubility 40g/l
pka pK1:1.90(+1) (25°C)
form Crystals or Powder
color White to off-white
Water Solubility 3.2 g/100ml (16.4 ºC)
BRN 107712
Exposure limits NIOSH: IDLH 25 mg/m3
Stability Stable. Incompatible with strong bases, strong oxidizing agents, strong acids.
InChI 1S/C6H4N2/c7-5-6-1-3-8-4-2-6/h1-4H
InChIKey GPHQHTOMRSGBNZ-UHFFFAOYSA-N
SMILES N#Cc1ccncc1
LogP 0.46 at 25℃
CAS DataBase Reference 100-48-1(CAS DataBase Reference)
FDA UNII BY3226D010
NIST Chemistry Reference 4-Pyridinecarbonitrile(100-48-1)
EPA Substance Registry System 4-Pyridinecarbonitrile (100-48-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Precautionary statements  P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36/37-24/25
RIDADR  3276
WGK Germany  3
TSCA  TSCA listed
PackingGroup  III
HS Code  29333999
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
NFPA 704
2
2 0

4-Cyanopyridine price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C95005 4-Pyridinecarbonitrile 98% 100-48-1 100g $25.5 2025-07-31 Buy
TCI Chemical C0457 4-Cyanopyridine >98.0%(GC)(T) 100-48-1 25g $16 2025-07-31 Buy
TCI Chemical C0457 4-Cyanopyridine >98.0%(GC)(T) 100-48-1 100g $32 2025-07-31 Buy
TCI Chemical C0457 4-Cyanopyridine >98.0%(GC)(T) 100-48-1 500g $105 2025-07-31 Buy
TRC C982225 4-Cyanopyridine 100-48-1 50g $85 2021-12-16 Buy
Product number Packaging Price Buy
C95005 100g $25.5 Buy
C0457 25g $16 Buy
C0457 100g $32 Buy
C0457 500g $105 Buy
C982225 50g $85 Buy

4-Cyanopyridine Chemical Properties,Uses,Production

Chemical Properties

beige solid

Chemical Properties

The cyanopyridines are as follows: 2-cyano-: A white to tan liquid or solid. Almond odor. Boiling point=2213℃ ; freezing/melting point=27℃ ; flash point=89℃ . 3-cyano-: a colorless liquid or gray crystal- line solid.

Uses

4-Cyanopyridine is used as an intermediate in organic synthesis and pharmaceutical substances like isonicotinylhydrazide, which is used in the treatment of tuberculosis. It is used as a precursor for the preparation of isonicotinic acid and 4-diemthylaminopyridine (DMAP). It is involved in the synthesis of 6-methyl-2-pyridin-4-yl-pyrimidin-4-ylamine by reacting with acetonitrile.

Synthesis

4-Cyanopyridine is synthesised by the reaction of 4-methylpyridine with ammonia and air in the presence of a catalyst. The specific synthesis steps are as follows:
4-Methylpyridine and ammonia vaporisation preheating to 180-330°C, then into the mixing tank and air mixing uniformly, into the fixed-bed reactor by the top of the fixed-bed reactor after the distribution of the catalyst-filled reactor, the control of the reaction temperature in the range of 330-450 ° C, the reaction head pressure is controlled in the range of 0.020-0.070 KPa, the reaction temperature is controlled by molten salts, the reaction gas after the end of the reaction After the reaction, the reaction gas was condensed to sub-zero fractionation to obtain the crude product of 4-cyanopyridine, and the crude product was distilled to obtain the finished product of 4-cyanopyridine. The conversion rate of 4-methylpyridine was above 99%, and the yield of 4-cyanopyridine was above 98%.
4-Cyanopyridine synthesis

Potential Exposure

Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period.

Shipping

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).

Incompatibilities

Oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .

4-Cyanopyridine synthesis

872-85-5
100-48-1
Synthesis of 4-Cyanopyridine from 4-Pyridinecarboxaldehyde

4-Cyanopyridine Preparation Products And Raw materials

Raw materials

4-Pyridinealdoxime Isonicotinamide

Preparation Products

4-AMINOMETHYL-PYRIDINE-2-CARBOXYLIC ACID 2-TERT-BUTYLPYRIDINE-4-CARBONITRILE 2-tert-Butylpyridine-4-carboxylic acid ,97% 4-Pyridylamidoxime 3-Chloro-4-cyanopyridine
4-[(TERT-BUTOXYCARBONYLAMINO)METHYL]-2-CYANOPYRIDINE 4-Pyridinemethaneamine 4-(BOC-AMINOMETHYL)PYRIDINE-2-CARBOXYLIC ACID PYRIDINE-2,4-DICARBONITRILE 4-AMIDINOPYRIDINIUM CHLORIDE
4-(BOC-AMINOMETHYL)PYRIDINE 4-CYANOPYRIDIN-3-YLBORONIC ACID 4-(4-CHLOROBENZOYL)PYRIDINE 4-TERT-BUTYLPYRIDINE 2-Picolylamine
4-PYRIDINECARBOXAMIDINE 4-Pyridylcarbinol Ethyl isonicotinate 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE

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4-Cyanopyridine Suppliers

Global( 593)Suppliers
Supplier Tel Email Country ProdList Advantage
HANGZHOU LEAP CHEM CO., LTD.
+86-571-87711850 market18@leapchem.com China 43333 58
Junwee Chemical co., Ltd.
+86-571-85808636 +86-13958122542 sales@junweechem.com China 823 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8753 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21597 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998 sales@czwytech.com CHINA 904 58
Supplier Advantage
HANGZHOU LEAP CHEM CO., LTD.
58
Junwee Chemical co., Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Biochempartner 		58
Cangzhou Wanyou New Material Technology Co.,Ltd 		58

Related articles

View Lastest Price from 4-Cyanopyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Cyanopyridine pictures 2026-02-16 4-Cyanopyridine
100-48-1
 0.99 RongNa Biotechnology Co.,Ltd
4-Cyanopyridine pictures 2026-01-30 4-Cyanopyridine
100-48-1
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
4-Cyanopyridine pictures 2025-12-03 4-Cyanopyridine
100-48-1
 US $68.00 / Kg/Bag 1KG 98% 10T Baoji Guokang Healthchem Co., Ltd.
  • 4-Cyanopyridine pictures
  • 4-Cyanopyridine
    100-48-1
  • US $10.00 / KG
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd
  • 4-Cyanopyridine pictures
  • 4-Cyanopyridine
    100-48-1
  • US $68.00 / Kg/Bag
  • 98%
  • Baoji Guokang Healthchem Co., Ltd.

4-Cyanopyridine Spectrum

4-Cyanopyridine(100-48-1)MS4-Cyanopyridine(100-48-1)1HNMR4-Cyanopyridine(100-48-1)13CNMR4-Cyanopyridine(100-48-1)IR14-Cyanopyridine(100-48-1)IR24-Cyanopyridine(100-48-1)IR3

100-48-1(4-Cyanopyridine)Related Search:

2-Cyanopyridine, Picolinonitrile,2-CYANOPYRIDINE 99% Cyanoacetic acid Methylene dithiocyanate Sodium cyanoborohydride 2-Chloro-3-cyanopyridine
Ethyl N-cyanoethanimideate ETHYL 2-CYANOACRYLATE 2,6-Pyridinedicarbonitrile 2-Pyridinecarboxaldehyde 3-Pyridinecarboxaldehyde
3,4-Pyridinedicarboxylic acid Isonicotinic acid Methyl isonicotinate hexyl isooctadecanoate Ethyl isonicotinate
SODIUM ISOSTEAROYL-2-LACTYLATE PYRIDINE-3,4-DICARBONITRILE 3-Cyanopyridine, Nicotinic acid nitrile, Nicotinonitrile

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ISONICOTINIC ACID NITRILE ISONICOTINONITRILE AKOS BBS-00004486 4-PYRIDINECARBONITRILE 4-CYANOPYRIDINE 4-Pyridinecarbonitrile 98% Topiroxostat impurity B(Isoniazid Impurity 5) 4-cyanopyridine (4-CP) TIMTEC-BB SBB008923 SPECS AC-907/25014099 gamma-Cyanopyridine Pyridine-4-carbonitrile 4-Pyridinenitrile Cyanopyridine,4- 4-cyanopyridin Isonicotinic cid nitrile 4-Cyanopyridine ,99% 4-Pyridinecarbonitrile,4-Cyanopyridine, Isonicotinic acid nitrile, Isonicotinonitrile 4-Pyridinecarbonitri 4-Cyanopyridine, 98% 100GR 4-Cyanopyridine, 98% 500GR 4-Cyanopyridine, 98% 5GR 4-Cyanopyridine, Isonicotinic acid nitrile, Isonicotinonitrile 4-Cyanopyridine,98% 4-PYRIDINECARBONITRILE FOR SYNTHESIS Topiroxostat Impurity 2 ( Isoniazid Impurity 5 ) 4-Cyanopyridine/4-Pyridinenitrile Fampridine Impurity 2 (4-Cyanopyridine) 4-Cyanopyridine > Fampridine Impurity 2 Ethionamide EP Impurity B Fampridine Impurity 9（4-Cyanopyridine） Isonicotinonitril 4-Cyanopyridine ISO 9001：2015 REACH Ethionamide Impurity 2 (Ethionamide EP Impurity B) 2-Methyl-104-nitrobenzyl&chloride Isoniazid EP Impurity C Ethionamide Impurity B Isoniazid EP Impurity C(Topiroxostat Impurity B) 4-cyanopyridine, 99%min 100-48-1 83880-65-9 C5H3NCN C6H4N Pyridines Heterocyclic Building Blocks Building Blocks C6 Heterocycle-Pyridine series cyanide Pyridines derivates bc0001