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ChemicalBook >> CAS DataBase List >>Big endothelin-1 (1-31) (human, bovine)

Big endothelin-1 (1-31) (human, bovine)

Big endothelin-1 (1-31) (human, bovine) Structure
Big endothelin-1 (1-31) (human, bovine) structure
CAS No.
133972-52-8
Chemical Name:
Big endothelin-1 (1-31) (human, bovine)
Synonyms
1-31-Human big endothelin 1;ENDOTHELIN-1 (1-31) (HUMAN);BIG ET-1 (1-31) (HUMAN, BOVINE);Big endothelin-1 (1-31) (human, bovine);BIG ET-1 (1-31) (HUMAN, BOVINE) TRIFLUOROACETATE SALT;BIG ENDOTHELIN-1 (1-31) (HUMAN, BOVINE) TRIFLUOROACETATE SALT;Big Endothelin-1 (1-31) (huMan, bovine) Big ET-1 (1-31) (huMan, bovine);CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR;H-CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR-OH;Endothelin 1 (swine), 21a-L-valine-21b-L-asparagine-21c-L-threonine-21d-L-proline-21e-L-glutamic acid-21f-L-histidine-21g-L-valine-21h-L-valine-21i-L-proline-21j-L-tyrosine-
CBNumber:
CB0690733
Molecular Formula:
C162H236N38O47S5
Molecular Weight:
3628.16
MDL Number:
MFCD01866298
MOL File:
133972-52-8.mol
TDS File:
TDS
Last updated:2026-09-12 18:48:27
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Big endothelin-1 (1-31) (human, bovine) Properties

storage temp. -15°C
Sequence Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)

Big endothelin-1 (1-31) (human, bovine) price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth PED-4360-S Endothelin-1 (1-31) (Human) 133972-52-8 0.1mg $816.7 2026-06-04 Buy
Biosynth FB109624 Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt ) 133972-52-8 50ug $900 2026-06-04 Buy
Biosynth FB109624 Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt ) 133972-52-8 100ug $900 2026-06-04 Buy
Biosynth FB109624 Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt ) 133972-52-8 25ug $900 2026-06-04 Buy
Biosynth FB109624 Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt ) 133972-52-8 250ug $1622.5 2026-06-04 Buy
Product number Packaging Price Buy
PED-4360-S 0.1mg $816.7 Buy
FB109624 50ug $900 Buy
FB109624 100ug $900 Buy
FB109624 25ug $900 Buy
FB109624 250ug $1622.5 Buy

Big endothelin-1 (1-31) (human, bovine) Chemical Properties, Uses, Production

Uses

Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase[1].

in vivo

ET-1 (1-31) (100 nM; single dose) induces contraction in the mouse mesenteric artery. The contraction may be mediated by the ETA receptor and may be increased by aging. A clear difference exists between males and females in the present chronic diabetic condition[1].

Animal Model:ICR mice, Streptozocin (HY-13753)-induced diabetic model[1]
Dosage:100 nM
Administration:In the organ bath, single dose
Result:In the 1-week control (but not diabetic) group, induced contraction and the contractile response was significantly greater in female mice than in male mice, and there was no significant difference in either male or female mice between the age-matched controls and the diabetic mice. In the 8-weeks group, the contraction was or tended to be increased compared with the corresponding 1-week group in all mice. Although in male mice this contraction was not different between control and diabetic groups, it was significantly greater in diabetic female mice than in the control female mice and in female diabetic mice than in male diabetic mice. The contraction was inhibited by ETA receptor inhibitor.

References

[1] Matsumoto T, et al. Gender differences in vascular reactivity to endothelin-1 (1-31) in mesenteric arteries from diabetic mice. Peptides. 2008 Aug;29(8):1338-46. DOI:10.1016/j.peptides.2008.04.001
[2] Yoshizumi M, et al. Effect of endothelin-1 (1-31) on human mesangial cell proliferation. Jpn J Pharmacol. 2000 Oct;84(2):146-55. DOI:10.1254/jjp.84.146

Big endothelin-1 (1-31) (human, bovine) Preparation Products And Raw materials

Raw materials

Preparation Products

Big endothelin-1 (1-31) (human, bovine) Suppliers

Global Suppliers ( 39)
Supplier Tel Email Country ProdList Advantage
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Cellmano Biotech Limited 0551-65326643 18156095617 info@cellmano.com China 1010 55
Nanjing Leon Biological Technology Co., Ltd. 025-84523390 -127; 17705183659 sales@njleonbiotech.com China 5501 55
Nanjing Peptide Biotech Ltd. 025-58361106-805 15951641583 zhao.xu@njpeptide.com China 9976 55
Chengdu Youngshe Chemical Co., Ltd. +86-17380623303 Caroline@youngshechem.com China 4726 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 15967184799 Eric@peptidego.com China 7872 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19087 58
Cellmano Biotech Limited 0551-65326643 18156095617 info@cellmano.com China 995 58
Supplier Advantage
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Cellmano Biotech Limited 55
Nanjing Leon Biological Technology Co., Ltd. 55
Nanjing Peptide Biotech Ltd. 55
Chengdu Youngshe Chemical Co., Ltd. 58
Hangzhou Peptidego Biotech Co.,Ltd. 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. 58
Cellmano Biotech Limited 58

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Big Endothelin-1 (1-31) (huMan, bovine) Big ET-1 (1-31) (huMan, bovine) BIG ET-1 (1-31) (HUMAN, BOVINE) BIG ET-1 (1-31) (HUMAN, BOVINE) TRIFLUOROACETATE SALT BIG ENDOTHELIN-1 (1-31) (HUMAN, BOVINE) TRIFLUOROACETATE SALT ENDOTHELIN-1 (1-31) (HUMAN) CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR H-CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR-OH Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-OH trifluoroacetate salt (Disulfide bonds between Cys1 and Cys15/Cys3 and Cys11) Endothelin 1 (swine), 21a-L-valine-21b-L-asparagine-21c-L-threonine-21d-L-proline-21e-L-glutamic acid-21f-L-histidine-21g-L-valine-21h-L-valine-21i-L-proline-21j-L-tyrosine- 1-31-Human big endothelin 1 Big endothelin-1 (1-31) (human, bovine) 133972-52-8 C162H236N38O47S5