5-Fluoro-2-nitroanisole
- CAS No.
- 448-19-1
- Chemical Name:
- 5-Fluoro-2-nitroanisole
- Synonyms
- 4-FLUORO-2-METHOXY-1-NITROBENZENE;1-Fluoro-3-Methoxy-4-nitrobenzene;5-Fluoro-2-nitroanis;5-FLUORO-2-NITROANISOL;5-FLUORO-2-NITROANISOLE;Osimertinib Impurity 03;2-Nitro-5-Fluoro Anisole;5-Fluoro-2-nitroanisole99%;5-Fluoro-2-nitroanisole>uoro-2-methoxy-1-nitrobenzene
- CBNumber:
- CB0707512
- Molecular Formula:
- C7H6FNO3
- Molecular Weight:
- 171.13
- MDL Number:
- MFCD00077541
- MOL File:
- 448-19-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Fluoro-2-nitroanisole >98.0%(GC) | F0703 | 5g | $21 |
| 5-Fluoro-2-nitroanisole >98.0%(GC) | F0703 | 25g | $61 |
| 3-Fluoro-6-nitroanisole | F593770 | 10g | $155 |
| 5-Fluoro-2-nitroanisole 97% | 033120 | 25g | $40 |
| 5-Fluoro-2-nitroanisole 99% | PC0827 | 25g | $41 |
| More product size | |||
| Melting point | 49-51°C |
|---|---|
| Boiling point | 272°C(lit.) |
| Density | 1.321±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Amber |
| InChI | InChI=1S/C7H6FNO3/c1-12-7-4-5(8)2-3-6(7)9(10)11/h2-4H,1H3 |
| InChIKey | WLKUSVNHZXUEFO-UHFFFAOYSA-N |
| SMILES | C1([N+]([O-])=O)=CC=C(F)C=C1OC |
| CAS DataBase Reference | 448-19-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H341 | |||||||||
| Precautionary statements | P201-P202-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-52 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2909309090 | |||||||||
| NFPA 704 |
|
5-Fluoro-2-nitroanisole price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0703 | 5-Fluoro-2-nitroanisole >98.0%(GC) | 448-19-1 | 5g | $21 | 2025-07-31 | Buy |
| TCI Chemical | F0703 | 5-Fluoro-2-nitroanisole >98.0%(GC) | 448-19-1 | 25g | $61 | 2025-07-31 | Buy |
| TRC | F593770 | 3-Fluoro-6-nitroanisole | 448-19-1 | 10g | $155 | 2021-12-16 | Buy |
| Oakwood | 033120 | 5-Fluoro-2-nitroanisole 97% | 448-19-1 | 25g | $40 | 2021-12-16 | Buy |
| Apolloscientific | PC0827 | 5-Fluoro-2-nitroanisole 99% | 448-19-1 | 25g | $41 | 2021-12-16 | Buy |
5-Fluoro-2-nitroanisole Chemical Properties,Uses,Production
Uses
3-Fluoro-6-nitroanisole is a reagent used in the synthetic preparation of imidazopyridines as inhibitors of insulin-like growth factor-1 receptor.
Synthesis
446-36-6
77-78-1
448-19-1
In a 5L four-necked flask, 2500 g of N,N-dimethylformamide (DMF), 5-fluoro-2-nitrophenol (500 g, 3.20 mol) and anhydrous potassium carbonate (483 g, 3.50 mol) were added and the mixture was heated up to 60 °C. Dimethyl sulfate (424 g, 3.36 mol) was slowly added dropwise for a controlled period of 2-3 hours. After the dropwise addition, the reaction temperature was raised to 90-100 °C and the reaction was maintained for 5-6 hours. The reaction progress was monitored by gas chromatography (GC) until the content of 5-fluoro-2-nitrophenol was below 0.5%. The reaction mixture was cooled to 50 °C, at which point the monomethyl potassium sulfate salt precipitated. The filtrate was subjected to decompression distillation to recover DMF, resulting in 2-nitro-5-fluoroanisole (515 g, yellow oily liquid). The product was analyzed by GC with 99.5% purity and 94.1% yield.
References
[1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2323 - 2332
[2] Patent: CN106083536, 2016, A. Location in patent: Paragraph 0035; 0036
[3] Heterocycles, 1992, vol. 34, # 12, p. 2301 - 2311
[4] Patent: WO2010/71885, 2010, A1. Location in patent: Page/Page column 443
[5] Patent: WO2010/115688, 2010, A1. Location in patent: Page/Page column 146
5-Fluoro-2-nitroanisole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +1-5184799099 | lbaochemicals@gmail.com | China | 674 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5242 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21597 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
View Lastest Price from 5-Fluoro-2-nitroanisole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-02-15 | 5-Fluoro-2-nitroanisole
448-19-1
|
US $0.00 / kg | 1kg | 98% | Customise | Hefei Lbao Physical & Chemical Science Co.,Ltd | |
 |
2026-01-30 | 5-Fluoro-2-nitroanisole
448-19-1
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-25 | 5-Fluoro-2-nitroanisole
448-19-1
|
US $0.00 / gram | 1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited |
-
- 5-Fluoro-2-nitroanisole
448-19-1
- US $0.00 / kg
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 5-Fluoro-2-nitroanisole
448-19-1
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Fluoro-2-nitroanisole
448-19-1
- US $0.00 / gram
- 99%
- Zhejiang J&C Biological Technology Co.,Limited
