Ethyl 4-hydroxyphenylacetate
- CAS No.
- 17138-28-2
- Chemical Name:
- Ethyl 4-hydroxyphenylacetate
- Synonyms
- EPAN-003;AKOS 90925;ETHYL 4-HYDROXYPHENYLACETATE;2-(4-hydroxyphenyl)butanoate;Ethyl (p-Hydroxyphenyl)acetate;Ethyl4-Hydroxyphenylacetate>ETHYL-4-HYDROXYPHENYLACETIC ACID;Ethyl 2-(p-Hydroxyphenyl)acetate;ETHYL 2-(4-HYDROXYPHENYL)ACETATE;4-hydroxy-benzeneaceticaciethylester
- CBNumber:
- CB0714983
- Molecular Formula:
- C10H12O3
- Molecular Weight:
- 180.2
- MDL Number:
- MFCD00016491
- MOL File:
- 17138-28-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| ethyl (4-hydroxyphenyl)acetate AldrichCPR | PH011119 | 500mg | $172 |
| Ethyl 4-Hydroxyphenylacetate >98.0%(GC) | E1034 | 5g | $46 |
| Ethyl 4-Hydroxyphenylacetate >98.0%(GC) | E1034 | 25g | $176 |
| Ethyl 2-(4-hydroxyphenyl)acetate 96% | CD12133419 | 10g | $64 |
| 4-Hydroxyphenylacetic acid ethyl ester 97% | MT-15447 | 500g | $488 |
| More product size | |||
| Melting point | 36-38°C |
|---|---|
| Boiling point | 187-189°C 20mm |
| Density | 1.146±0.06 g/cm3(Predicted) |
| refractive index | 1.52 |
| Flash point | 187-189°C/20mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform |
| form | Brown Semi-Solid |
| pka | 9.84±0.15(Predicted) |
| color | White or Colorless to Light yellow |
| LogP | 1.760 (est) |
| CAS DataBase Reference | 17138-28-2(CAS DataBase Reference) |
| FDA UNII | 94NWB742CW |
| NIST Chemistry Reference | Benzeneacetic acid, 4-hydroxy-, ethyl ester(17138-28-2) |
| EPA Substance Registry System | Benzeneacetic acid, 4-hydroxy-, ethyl ester (17138-28-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2916340000 | |||||||||
| NFPA 704 |
|
Ethyl 4-hydroxyphenylacetate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PH011119 | ethyl (4-hydroxyphenyl)acetate AldrichCPR | 17138-28-2 | 500mg | $172 | 2023-06-20 | Buy |
| TCI Chemical | E1034 | Ethyl 4-Hydroxyphenylacetate >98.0%(GC) | 17138-28-2 | 5g | $46 | 2026-04-30 | Buy |
| TCI Chemical | E1034 | Ethyl 4-Hydroxyphenylacetate >98.0%(GC) | 17138-28-2 | 25g | $176 | 2026-04-30 | Buy |
| Crysdot | CD12133419 | Ethyl 2-(4-hydroxyphenyl)acetate 96% | 17138-28-2 | 10g | $64 | 2026-05-27 | Buy |
| AHH | MT-15447 | 4-Hydroxyphenylacetic acid ethyl ester 97% | 500g | $488 | 2026-05-26 | Buy |
Ethyl 4-hydroxyphenylacetate Chemical Properties,Uses,Production
Chemical Properties
Brown Semi-Solid
Uses
Ethyl 4-hydroxyphenylacetate is a useful synthetic intermediate for the preparation of novel antiinflammatory agents.
Synthesis
156-38-7
64-17-5
17138-28-2
4-Hydroxyphenylacetic acid (10.0 g, 65.7 mmol), anhydrous ethanol (120 mL), and concentrated hydrochloric acid (1 mL) were added to a round bottom flask. The reaction mixture was heated to reflux for 1 h and subsequently cooled to room temperature. The reaction mixture was neutralized in a small amount with saturated aqueous sodium bicarbonate solution. Most of the ethanol was evaporated under reduced pressure. The aqueous phase was extracted with ethyl acetate and the organic phase was sequentially washed well with water and dried with anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the target product ethyl p-hydroxyphenylacetate as an oil (11.8 g, 100% yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 7.13 (d, 2H), 6.76 (d, 2H), 5.10 (s, 1H), 4.15 (q, 2H), 3.36 (s, 2H), 1.26 (t, 3H).
target
MAO
References
[1] Patent: WO2006/20916, 2006, A2. Location in patent: Page/Page column 79
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 22, p. 8092 - 8105
[3] Synthesis, 2003, # 16, p. 2479 - 2482
[4] Patent: US2003/191181, 2003, A1. Location in patent: Page/Page column 10; 15
[5] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1651 - 1656
Ethyl 4-hydroxyphenylacetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from Ethyl 4-hydroxyphenylacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Ethyl 4-hydroxyphenylacetate
17138-28-2
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2021-08-12 | Ethyl 4-hydroxyphenylacetate
17138-28-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-13 | Ethyl 4-hydroxyphenylacetate
17138-28-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Ethyl 4-hydroxyphenylacetate
17138-28-2
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethyl 4-hydroxyphenylacetate
17138-28-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Ethyl 4-hydroxyphenylacetate
17138-28-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
