2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE
- CAS No.
- 68236-20-4
- Chemical Name:
- 2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE
- Synonyms
- AKOS NCG-0061;AKOS BBS-00006540;2-Chloro-7-methoxyquinoline-2-carbaldehyde;2-CHLORO-7-METHOXY-3-QUINOLINECARBALDEHYDE;2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE;2-Chloro-7-methoxy-3-quinolinecarboxaldehyde;2-Chloro-7-methoxyquinoline-3-carboxaldehyde;3-Quinolinecarboxaldehyde,2-chloro-7-methoxy-;2-chloro-7-methoxy-1H-quinoline-2-carboxaldehyde;2-Chloro-7-methoxy-3-quinolinecarboxaldehyde - [AC78577]
- CBNumber:
- CB0751883
- Molecular Formula:
- C11H8ClNO2
- Molecular Weight:
- 221.64
- MDL Number:
- MFCD02227048
- MOL File:
- 68236-20-4.mol
- MSDS File:
- SDS
| Melting point | 196-198°C |
|---|---|
| Boiling point | 373.9±37.0 °C(Predicted) |
| Density | 1.348±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | -1.00±0.50(Predicted) |
| Appearance | Pink to red Solid |
| InChI | 1S/C11H8ClNO2/c1-15-9-3-2-7-4-8(6-14)11(12)13-10(7)5-9/h2-6H,1H3 |
| InChIKey | WRXZCLBKDXISQA-UHFFFAOYSA-N |
| SMILES | COC1=CC=C2C=C(C(Cl)=NC2=C1)C=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 36-22 |
| Safety Statements | 26 |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 2933499090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BBO000762 | 2-Chloro-7-methoxyquinoline-3-carboxaldehyde | 68236-20-4 | 1 g | $230 | 2026-04-30 | Buy |
| Usbiological | 269230 | 2-Chloro-7-methoxy-quinoline-3-carbaldehyde Asreported | 68236-20-4 | 10g | $382 | 2026-06-03 | Buy |
| Usbiological | 269230 | 2-Chloro-7-methoxy-quinoline-3-carbaldehyde Asreported | 68236-20-4 | 25g | $542 | 2026-06-03 | Buy |
| Usbiological | 269230 | 2-Chloro-7-methoxy-quinoline-3-carbaldehyde Asreported | 68236-20-4 | 50g | $761 | 2026-06-03 | Buy |
| Usbiological | 269230 | 2-Chloro-7-methoxy-quinoline-3-carbaldehyde Asreported | 68236-20-4 | 100g | $1055 | 2026-06-03 | Buy |
2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE Chemical Properties,Uses,Production
Preparation
The preparation of 2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE is as follows: N-p-tolylacetamide (2b) (0.05 mol) was dissolved in 9.6 mL of dimethylformamide (0.125 mol), and 32 mL of phosphorus oxychloride (0.35 mol) was gradually added to the solution at 0 °C. The reaction mixture was placed in a round-bottom flask (RBF) equipped with a reflux condenser and a drying tube, and heated in an oil bath at 75-80 °C for 4-16 hours. The solution was then cooled to room temperature and subsequently poured into 100 mL of ice water. The precipitate was collected by filtration and recrystallized from ethyl acetate to give 2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE, yield 75%; MP 122-123℃ (literature 123℃); FT-IR (ATR) ⁻¹ (cm⁻¹): 3051 (aromatic CH), 2873 (aldehyde CH), 1686 (C=O), 1576 (C=N), 1055 (C-Cl); ¹H NMR (400 MHz, chloroform-d): ⁻¹ 0.55 (s, 1H), 8.66 (s, 1H), 7.96 (d, J = 8.5 Hz, 1H), 7.79-7.63 (m, 2H), 2.57 (s, 3H); MS-API: [M+H] + 206.02 (calculated 205.03).
Application
2-Chloro-7-methoxy-3-quinoline carbaldehyde can be used as a pharmaceutical synthesis intermediate.
2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Tianjing Geneston Bio-tech Co.,Ltd. | 022-60131465 18920720807 | zishan_1986@163.com | China | 744 | 58 |
| Wuhan Chemwish Technology Co.， Ltd | 027-67849912 | sales@chemwish.com | China | 9144 | 60 |
| AOKBIO Inc. | 021-68712331 3286104197 | China | 321 | 55 |
68236-20-4(2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE)Related Search:
1of4
