CYCLOCREATINE
- CAS No.
- 35404-50-3
- Chemical Name:
- CYCLOCREATINE
- Synonyms
- CYCLOCREATINE;2-imino-1-imidazolinolinic acid;2-IMINO-1-IMIDAZOLIDINEACETIC ACID;1-Carboxymethyl-2-iminoimidazolidin;1-CARBOXYMETHYL-2-IMINOIMIDAZOLIDINE;(2-Iminoimidazolidin-1-yl)acetic acid;2-Imino-1-imidazolidineacetic acid 98%;2-(2-Iminoimidazolidin-1-yl)acetic acid;2-(2-iminoimidazolidine-1-yl)acetic acid;2-Amino-4,5-dihydro-1H-Imidazole-1-acetic Acid
- CBNumber:
- CB0755285
- Molecular Formula:
- C5H9N3O2
- Molecular Weight:
- 143.14
- MDL Number:
- MFCD00134455
- MOL File:
- 35404-50-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Imino-1-imidazolidineacetic acid 98% | 377627 | 1g | $147 |
| Cyclocreatine ≥95% | 20649 | 500mg | $49 |
| Cyclocreatine ≥95% | 20649 | 1g | $77 |
| Cyclocreatine | 20649 | 5g | $356 |
| Cyclocreatine | 20649 | 10g | $570 |
| More product size | |||
| Melting point | 322-326C |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | 1 M HCl: soluble25mg/mL, clear, colorless |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C5H9N3O2/c6-5-7-1-2-8(5)3-4(9)10/h1-3H2,(H2,6,7)(H,9,10) |
| InChIKey | AMHZIUVRYRVYBA-UHFFFAOYSA-N |
| SMILES | C1(N)N(CC(O)=O)CCN=1 |
| CAS DataBase Reference | 35404-50-3(CAS DataBase Reference) |
| FDA UNII | 6732XGX1RK |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2940000080 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
CYCLOCREATINE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 377627 | 2-Imino-1-imidazolidineacetic acid 98% | 35404-50-3 | 1g | $147 | 2026-03-19 | Buy |
| Cayman Chemical | 20649 | Cyclocreatine ≥95% | 35404-50-3 | 500mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 20649 | Cyclocreatine ≥95% | 35404-50-3 | 1g | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 20649 | Cyclocreatine | 35404-50-3 | 5g | $356 | 2024-03-01 | Buy |
| Cayman Chemical | 20649 | Cyclocreatine | 35404-50-3 | 10g | $570 | 2024-03-01 | Buy |
CYCLOCREATINE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Cyclocreatine is used to regulate creatine biosynthesis by suppressing the level of arginine:glycine amidinotransferase in chick liver.
Uses
Can regulate creatine biosynthesis by suppressing the level of arginine:glycine amidinotransferase in chick liver
Biological Activity
Creatine analog th at protects tissues from ischemic damage; decreases the rate of ATP production via creatine kinase and reduces the proliferation of tumor cell lines th at are characterized by high levels of creatine kinase expression.
in vivo
Cyclocreatine (500 mg/kg, i.v., a single dose for 60 min) restores heart contractile function and shows markedly less myocardial cell injury when compared to the control (saline) group in the acute myocardial infarction (AMI) intact dog model[1].
Cyclocreatine (0.28 mg/g, drink, supplementation daily from 10-week to 8 months) rescues microgliosis and clustering and moderates neurite dystrophy in TREM2/ 5XFAD mice[2].
Cyclocreatine (40 mg, gavage, daily for 1 month) significantly reduces liver metastatic burden and affects prostate cancer progression in a model of liver metastasis of mice[3].
| Animal Model: | AMI-intact dog model[1] |
| Dosage: | 500 mg/kg |
| Administration: | i.v., a single dose for 60 min |
| Result: | Preserved 85% of pre-ischemic ATP level (loss of only 15%) and 97% of the CrP (loss of 3%) during ischemia, as well as immediately restored over 80% of contractile function during the 2 h of reperfusion in AMI-intact dog model. |
| Animal Model: | 5XFAD and TREM2/ 5XFAD mice |
| Dosage: | 0.28 mg/g |
| Administration: | Drinking water supplementation with cyclocreatine daily from 10-week to 8 months |
| Result: | Improved microglial metabolism and the protective response to Aβ plaques in TREM2-deficient 5XFAD mice. |
CYCLOCREATINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49968 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Hebei Fengmu Trading Co., Ltd. | +8613393234347 | Lyla@fengmuchem.com | China | 2943 | 58 |
View Lastest Price from CYCLOCREATINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | CYCLOCREATINE
35404-50-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-06 | CYCLOCREATINE
35404-50-3
|
US $1066.20 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- CYCLOCREATINE
35404-50-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- CYCLOCREATINE
35404-50-3
- US $1066.20 / KG
- 98%
- Career Henan Chemical Co
