N-(4-Oxocyclohexyl)phthalimide
- CAS No.
- 104618-32-8
- Chemical Name:
- N-(4-Oxocyclohexyl)phthalimide
- Synonyms
- 4-Phthalamido Cyclohexanone;4-(PHTHALIMIDO)-CYCLOHEXANONE;4-(phthaliMide)-cyclohexanone;N-(4-Oxocyclohexyl)phthalimide;N-(4-Oxocyclohexyl)phthalimide>N-(4-Oxocyclohexyl)phthalimide;4-Phthalimidocyclohexanone yclohexanone;2-(4-Oxo-cyclohexyl)-isoindole-1,3-dione;2-(4-oxocyclohexyl)isoindoline-1,3-dione;2-(4-Oxocyclohexyl)-1H-isoindol-1,3(2H)-dione
- CBNumber:
- CB0760692
- Molecular Formula:
- C14H13NO3
- Molecular Weight:
- 243.26
- MDL Number:
- MFCD00158659
- MOL File:
- 104618-32-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| N-(4-Oxocyclohexyl)phthalimide >98.0%(GC)(N) | O0365 | 5g | $49 |
| N-(4-Oxocyclohexyl)phthalimide >98.0%(GC)(N) | O0365 | 25g | $147 |
| N-(4-Oxocyclohexyl)Phthalimide | O849760 | 5g | $130 |
| N-(4-Oxocyclohexyl)Phthalimide | 52621 | 100g | $1050 |
| N-(4-OXOCYCLOHEXYL)PHTHALIMIDE 95.00% | CHM0127090 | 25G | $1255.86 |
| More product size | |||
| Melting point | 142.0 to 146.0 °C |
|---|---|
| Boiling point | 410.0±38.0 °C(Predicted) |
| Density | 1.357 |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | -2.27±0.20(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C14H13NO3/c16-10-7-5-9(6-8-10)15-13(17)11-3-1-2-4-12(11)14(15)18/h1-4,9H,5-8H2 |
| InChIKey | PWUJQPNLEZZILN-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC=C2)C(=O)N1C1CCC(=O)CC1 |
| CAS DataBase Reference | 104618-32-8 |
N-(4-Oxocyclohexyl)phthalimide price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | O0365 | N-(4-Oxocyclohexyl)phthalimide >98.0%(GC)(N) | 104618-32-8 | 5g | $49 | 2025-07-31 | Buy |
| TCI Chemical | O0365 | N-(4-Oxocyclohexyl)phthalimide >98.0%(GC)(N) | 104618-32-8 | 25g | $147 | 2025-07-31 | Buy |
| TRC | O849760 | N-(4-Oxocyclohexyl)Phthalimide | 104618-32-8 | 5g | $130 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 52621 | N-(4-Oxocyclohexyl)Phthalimide | 104618-32-8 | 100g | $1050 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0127090 | N-(4-OXOCYCLOHEXYL)PHTHALIMIDE 95.00% | 104618-32-8 | 25G | $1255.86 | 2021-12-16 | Buy |
N-(4-Oxocyclohexyl)phthalimide Chemical Properties,Uses,Production
Uses
N-(4-Oxocyclohexyl) Phthalimide is an impurity of Pramipexol (P700755), a dopamine-D2-receptor agonist used in the early treatment of Parkinson''s disease and restless legs syndrome.
Synthesis
104618-31-7
104618-32-8
Example 1: Synthesis of 4-(phthalimido)cyclohexanone 4-(Phthalimido)cyclohexanol (146 g) was mixed with ethyl acetate (1000 mL), followed by the addition of sodium bromide (8 g) and 2,2,6,6-tetramethylpiperidin-1-oxyl radical (TEMPO, 0.5 g). A 10% aqueous sodium hypochlorite solution (1000 mL) was added in batches and the pH of the reaction mixture was adjusted to 7-8 using sodium bicarbonate while maintaining the reaction temperature between 5 and 20 °C. Upon completion of the reaction, the aqueous layer was separated, and the organic layer was washed with saturated aqueous sodium chloride (400 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give a white solid product in 95% yield.
References
[1] Patent: WO2010/78250, 2010, A1. Location in patent: Page/Page column 12
[2] Patent: WO2006/3677, 2006, A1. Location in patent: Page/Page column 10; 16
[3] Patent: US2011/280808, 2011, A1. Location in patent: Page/Page column 62
[4] Journal of medicinal chemistry, 1993, vol. 36, # 13, p. 1918 - 1919
[5] Patent: US2003/100596, 2003, A1
N-(4-Oxocyclohexyl)phthalimide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Shanghai Yudiao Chemistry Technology Co.,Ltd | 02137285211 18964703211 | info@yudiaochem.com | CHINA | 238 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15142 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Changzhou Guiding Bio-Tech. Co.,Ltd. | +86-519-519-86686860 +8618795626222 | ning@guiding-bio.com | China | 299 | 58 |
| CHANGZHOU HARVECHEM LTD | +86-0519-88784888 +8613906120163 | inquiry@harvechem.com | China | 286 | 58 |
View Lastest Price from N-(4-Oxocyclohexyl)phthalimide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-(PHTHALIMIDO)-CYCLOHEXANONE
104618-32-8
|
US $1.00 / kg | 1kg | 99% | Customized | Career Henan Chemical Co |
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- 4-(PHTHALIMIDO)-CYCLOHEXANONE
104618-32-8
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
