MORPHOLIN-4-YL-ACETIC ACID
- CAS No.
- 89531-58-8
- Chemical Name:
- MORPHOLIN-4-YL-ACETIC ACID
- Synonyms
- 2-Morpholinoacetic acid hydrochloride;EOS-62303;AKOS BBS-00002525;RARECHEM AL BO 0383;TIMTEC-BB SBB010303;MORPHOLINOACETIC ACID;4-MORPHOLINOACETIC ACID;MORPHOLIN-4-YL-ACETIC ACID;4-MORPHOLINACETIC ACID HCL;4-Morpholineacetic acid HCL
- CBNumber:
- CB0773287
- Molecular Formula:
- C6H11NO3
- Molecular Weight:
- 145.16
- MDL Number:
- MFCD03540888
- MOL File:
- 89531-58-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Morpholinoacetic acid hydrochloride AldrichCPR | ANV00112 | 1G | $259 |
| Morpholinoacetic Acid Hydrochloride >98.0%(T) | M2608 | 1g | $37 |
| Morpholinoacetic Acid Hydrochloride >98.0%(T) | M2608 | 5g | $147 |
| 4-MorpholineaceticAcidHydrochloride | M722990 | 250mg | $70 |
| 4-MorpholineaceticAcidHydrochloride | M722990 | 10g | $445 |
| More product size | |||
| Melting point | 160-161℃ |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| form | Powder |
| color | White |
| Water Solubility | Insoluble in water. |
| InChI | InChI=1S/C6H11NO3/c8-6(9)5-7-1-3-10-4-2-7/h1-5H2,(H,8,9) |
| InChIKey | ICGYBJNONRDZOP-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CN1CCOCC1 |
| CAS DataBase Reference | 89531-58-8 |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
MORPHOLIN-4-YL-ACETIC ACID price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ANV00112 | 2-Morpholinoacetic acid hydrochloride AldrichCPR | 89531-58-8 | 1G | $259 | 2025-07-31 | Buy |
| TCI Chemical | M2608 | Morpholinoacetic Acid Hydrochloride >98.0%(T) | 89531-58-8 | 1g | $37 | 2025-07-31 | Buy |
| TCI Chemical | M2608 | Morpholinoacetic Acid Hydrochloride >98.0%(T) | 89531-58-8 | 5g | $147 | 2025-07-31 | Buy |
| TRC | M722990 | 4-MorpholineaceticAcidHydrochloride | 89531-58-8 | 250mg | $70 | 2021-12-16 | Buy |
| TRC | M722990 | 4-MorpholineaceticAcidHydrochloride | 89531-58-8 | 10g | $445 | 2021-12-16 | Buy |
MORPHOLIN-4-YL-ACETIC ACID Chemical Properties,Uses,Production
Uses
4-Morpholineacetic Acid Hydrochloride is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
Chemical Properties
White solid
Uses
4-Morpholineacetic Acid Hydrochloride is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
Synthesis
3235-82-3
89531-58-8
The general procedure for the synthesis of morpholine-4-acetic acid hydrochloride from ethyl 2-(4-morpholinyl)acetate is as follows: ethyl 4-morpholinoacetate (1.1 g, 6.3 mmol) was added to 3M hydrochloric acid solution (35 ml) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the mixture was stirred at room temperature for 24 hours. Subsequently, the reaction solution was concentrated under reduced pressure. The obtained residue was dissolved in methanol and concentrated again under reduced pressure. The final solid product obtained was suspended in ether, separated by filtration and dried under reduced pressure to give 1.05 g of morpholine-4-acetic acid hydrochloride in 91.7% yield. The product was characterized by NMR (DMSO-d6) with chemical shifts of 3.3 (s, 4H), 3.9 (s, 4H), 4.2 (s, 2H).
References
[1] Journal of the American Chemical Society, 2017, vol. 139, # 34, p. 11895 - 11902
[2] Patent: US6352993, 2002, B1. Location in patent: Page column 13
[3] Journal of Molecular Structure, 2001, vol. 560, # 1-3, p. 261 - 273
[4] Patent: US5521179, 1996, A
[5] Bioconjugate Chemistry, 2016, vol. 27, # 1, p. 226 - 237
MORPHOLIN-4-YL-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13676 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29832 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Shanghai zaiqi biology technology co., ltd | +86-21-54824098 13817598959 | sales@chemzq.com | CHINA | 136 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15080 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
View Lastest Price from MORPHOLIN-4-YL-ACETIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | MORPHOLIN-4-YL-ACETIC ACID
89531-58-8
|
US $1.00 / kg | 1kg | 98% | 100KG | Career Henan Chemical Co |
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- MORPHOLIN-4-YL-ACETIC ACID
89531-58-8
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
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