5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 29682-15-3
- Chemical Name:
- 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- METHYL 5-BROMOPICOLINATE;METHYL 5-BROMOPYRIDINE-2-CARBOXYLATE;5-Bromopyridine-2-carboxyL;5-broMopicolinic acid Methyl ester;Methyl-5-Bromopyridine-2-Carboxlate;METHYL 5-BROMO-2-PYRIDINECARBOXYLATE;Methyl 5-Bromopyridine-2-carboxylate >Methyl 5-bromopyridine-2-carboxylate, 98+%;Methyl 5-BroMopyridine-2-carboxylate, 97+%;5-bromopyridine-2-carboxylate methyl ester
- CBNumber:
- CB0777922
- Molecular Formula:
- C7H6BrNO2
- Molecular Weight:
- 216.03
- MDL Number:
- MFCD04112493
- MOL File:
- 29682-15-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| methyl 5-bromopyridine-2-carboxylate AldrichCPR | CDS003613 | 250mg | $77.9 |
| Methyl 5-Bromopyridine-2-carboxylate >98.0%(GC) | M2614 | 1g | $17 |
| Methyl 5-Bromopyridine-2-carboxylate >98.0%(GC) | M2614 | 5g | $51 |
| Methyl5-bromopicolinate | M296105 | 250mg | $55 |
| Methyl 5-bromopyridine-2-carboxylate 95+% | 072799 | 5g | $82 |
| More product size | |||
| Melting point | 101-103°C |
|---|---|
| Boiling point | 290.9±20.0 °C(Predicted) |
| Density | 1.579±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | -0.67±0.10(Predicted) |
| color | White to Almost white |
| Water Solubility | Soluble in water. |
| InChI | InChI=1S/C7H6BrNO2/c1-11-7(10)6-3-2-5(8)4-9-6/h2-4H,1H3 |
| InChIKey | JEURNBCYNWNADN-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC=C(Br)C=C1 |
| CAS DataBase Reference | 29682-15-3(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-36 | |||||||||
| Safety Statements | 26-37 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS003613 | methyl 5-bromopyridine-2-carboxylate AldrichCPR | 29682-15-3 | 250mg | $77.9 | 2026-03-19 | Buy |
| TCI Chemical | M2614 | Methyl 5-Bromopyridine-2-carboxylate >98.0%(GC) | 29682-15-3 | 1g | $17 | 2026-03-19 | Buy |
| TCI Chemical | M2614 | Methyl 5-Bromopyridine-2-carboxylate >98.0%(GC) | 29682-15-3 | 5g | $51 | 2026-03-19 | Buy |
| TRC | M296105 | Methyl5-bromopicolinate | 29682-15-3 | 250mg | $55 | 2021-12-16 | Buy |
| Matrix Scientific | 072799 | Methyl 5-bromopyridine-2-carboxylate 95+% | 29682-15-3 | 5g | $82 | 2021-12-16 | Buy |
5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Uses,Production
Uses
Methyl 5-bromopyridine-2-carboxylate is used as an organic chemical synthesis intermediate.
Synthesis
67-56-1
30766-11-1
29682-15-3
Example 89 - Preparation of Intermediate 25: The synthesis of Intermediate 25 followed the following general procedure. To a solution of 5-bromopyridine-2-carboxylic acid (50.0 g, 0.247 mol, 1.0 eq.) in anhydrous methanol (400 mL) cooled to 0 °C was added thionyl chloride (107.0 mL, 2.47 mol, 10.0 eq.) dropwise. The reaction mixture was slowly warmed to room temperature and subsequently heated at 50 °C for 12 hours. The reaction process was monitored by thin layer chromatography (TLC) and liquid chromatography-mass spectrometry (LC-MS). After completion of the reaction, the reaction mixture was concentrated under reduced pressure to give a white solid residue. The residue was slowly quenched with saturated sodium bicarbonate solution and the white solid was collected by filtration to afford the target product methyl 5-bromopyridine-2-carboxylate (43.0 g, 80% yield). The product was characterized by mass spectrometry (m/z 216.14) and nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, DMSO): δ 8.86 (d, J=1.9 Hz, 1H), 8.28 (dd, J=8.4,2.4 Hz, 1H), 8.00 (d, J=8.4 Hz, 1H), 3.89 (s, 3H) ppm.
References
[1] Patent: WO2018/126072, 2018, A1. Location in patent: Paragraph 0246; 0247
[2] Patent: WO2012/76898, 2012, A1. Location in patent: Page/Page column 64-65
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 22, p. 4780 - 4784
[4] Patent: WO2016/44662, 2016, A1. Location in patent: Paragraph 00379-00380
[5] Patent: CN103360407, 2016, B. Location in patent: Paragraph 0135-0137
5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8742 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20125 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29827 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-20 | 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
29682-15-3
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-01 | 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
29682-15-3
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-11-18 | 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
29682-15-3
|
US $1.10 / g | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
29682-15-3
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
29682-15-3
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
29682-15-3
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
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