REV 5901
- CAS No.
- 101910-24-1
- Chemical Name:
- REV 5901
- Synonyms
- RG-5901;PF-5901;REV 5901;RG-5901A;REV-ERBα Antagonist, SR8278;1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol;2-[3-(1-Hydroxyhexyl)phenoxymethyl]quinoline;α-pentyl-3-[2-quinolinylmethoxy]benzyl alcohol;Benzenemethanol,a-pentyl-3-(2-quinolinylmethoxy)-;Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-
- CBNumber:
- CB0784207
- Molecular Formula:
- C22H25NO2
- Molecular Weight:
- 335.44
- MDL Number:
- MFCD00211150
- MOL File:
- 101910-24-1.mol
| Product description | Number | Pack Size | Price |
| REV-ERBα Antagonist, SR8278 The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα. | 554718 | 5 mg | $196 |
| REV 5901 ≥98% | 70600 | 5mg | $32 |
| REV 5901 ≥98% | 70600 | 10mg | $61 |
| REV 5901 ≥98% | 70600 | 50mg | $243 |
| REV 5901 ≥98% | 70600 | 100mg | $426 |
| More product size | |||
| Boiling point | 497.7±35.0 °C(Predicted) |
|---|---|
| Density | 1.123±0.06 g/cm3(Predicted) |
| storage temp. | Room temperature |
| solubility | ≤100mg/ml in ethanol;100mg/ml in methanol;100mg/ml in acetone;100mg/ml in DMSO;100mg/ml in etonitrile. |
| form | Off-white to tan solid. |
| pka | 14.48±0.20(Predicted) |
| color | white to yellow-brown |
| InChIKey | JRLOEMCOOZSCQP-UHFFFAOYSA-N |
| SMILES | n1c2c(ccc1COc3cc(ccc3)C(O)CCCCC)cccc2 |
| FDA UNII | WNW5RYD8MG |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
REV 5901 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 554718 | REV-ERBα Antagonist, SR8278 The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα. | 101910-24-1 | 5 mg | $196 | 2025-07-31 | Buy |
| Cayman Chemical | 70600 | REV 5901 ≥98% | 101910-24-1 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 70600 | REV 5901 ≥98% | 101910-24-1 | 10mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 70600 | REV 5901 ≥98% | 101910-24-1 | 50mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 70600 | REV 5901 ≥98% | 101910-24-1 | 100mg | $426 | 2024-03-01 | Buy |
REV 5901 Chemical Properties,Uses,Production
Description
REV 5901 is an antagonist of cysteinyl-
Uses
REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 μM.
Uses
L-655,238 is a potent and selective inhibitor of FLAP (5-LO-activating protein).
Definition
ChEBI: 1-[3-(2-quinolinylmethoxy)phenyl]-1-hexanol is a member of quinolines.
in vitro
previous in-vitro showed that rev 5901 had a ki value of 0.7 μm vs. [3h]leukotriene d4 ([3h]-ltd4) binding to membranes from guinea pig lung. against ltc4-, ltd4- and lte4-induced contractions of guinea pig parenchymal strips, rev 5901 had kb values of ca 3 μm and was relatively ineffective against contractions that was induced by other spasmogens. moreover, in isolated guinea pig hearts, the peptiodoleukotriene-antagonist activity was also observed against the hemodynamic and vasoconstriction effects of ltd4. in addition, unlike other reported antagonists, rev 5901 was found to be ineffective against the multiple forms of cyclic nucleotide phosphodiesterases [1].
in vivo
animal study found that the oral antagonist activity had been shown with an ltd4-induced bronchoconstriction model and with an ltd4-induced wheal response model in guinea pigs [1].
References
[1] van inwegen, r. g.,khandwala, a.,gordon, r., et al. rev 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile. journal of pharmacology and experimental therapeutics 241, 117-124 (1987).
REV 5901 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2976 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | 1701086315 | dexuanpharma@126.com | China | 9475 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24963 | 58 |
