Trevogrumab
- CAS No.
- 1429201-24-0
- Chemical Name:
- Trevogrumab
- Synonyms
- Trevogrumab;Trevogrumab (anti-GDF8);Research Grade Trevogrumab;Research Grade Trevogrumab (DHA30602)
- CBNumber:
- CB08080943
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | 87T4327873 |
Trevogrumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CLA1395 | Trevogrumab | 1429201-24-0 | 1mg | $1125 | 2026-06-04 | Buy |
| Biosynth | CLA1395 | Trevogrumab | 1429201-24-0 | 2mg | $1625 | 2026-06-04 | Buy |
| Biosynth | CLA1395 | Trevogrumab | 1429201-24-0 | 5mg | $2875 | 2026-06-04 | Buy |
| Biosynth | CLA1395 | Trevogrumab | 1429201-24-0 | 10mg | $4250 | 2026-06-04 | Buy |
| Biosynth | CLA1395 | Trevogrumab | 1429201-24-0 | 25mg | $7375 | 2026-06-04 | Buy |
Trevogrumab Chemical Properties, Uses, Production
Uses
Trevogrumab (REGN-1033) is a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as myostatin). Trevogrumab is used in research on muscle wasting conditions, including disuse atrophy, chronic diseases, and changes in food and nutrient intake[1][2][3].
in vivo
Trevogrumab (10 mg/kg, s.c., twice a week for 4 weeks) significantly increases muscle mass and strength in CB17-SCID and C57BL/6 mice[3].
| Animal Model: | CB17-SCID and C57BL/6 mice[3] |
| Dosage: | 0.1-30 mg/kg |
| Administration: | Subcutaneous injection (s.c.), twice a week for 4 weeks |
| Result: | Significantly increased muscle weight (~20%) in gastrocnemius (GA) and tibialis anterior (TA) muscles and increased muscle fiber area (~15%) in mice. |
References
[1] Masakazu Saitoh, et al. Myostatin inhibitors as pharmacological treatment for muscle wasting and muscular dystrophy. Volume2, Issue1,January 2017,Pages 1-10
[2] Mitra A, et al. The elusive role of myostatin signaling for muscle regeneration and maintenance of muscle and bone homeostasis. Osteoporos Sarcopenia. 2023 Mar;9(1):1-7. DOI:10.1016/j.afos.2023.03.008
[3] Latres E, et al. Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice. Skelet Muscle. 2015 Oct 9;5:34. DOI:10.1186/s13395-015-0060-8
Trevogrumab Preparation Products And Raw materials
Raw materials
Preparation Products
Trevogrumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4593 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 6206333 13167063860 | anhua.mao@aladdin-e.com | China | 43439 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 15111215862 18229892877 | 3062105966@qq.com | China | 5550 | 58 |
