Lanadelumab
- CAS No.
- 1426055-14-2
- Chemical Name:
- Lanadelumab
- Synonyms
- Lanadelumab;Research Grade Lanadelumab;Research Grade Lanadelumab (DHC04301)
- CBNumber:
- CB08080983
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Lanadelumab 99.74% | CS-0535046 | 1mg | $325 |
| Lanadelumab 99.74% | CS-0535046 | 5mg | $845 |
| Lanadelumab 99.74% | CS-0535046 | 10mg | $1354 |
| Lanadelumab >98% | AA029N97 | 1mg | $369 |
| Lanadelumab >98% | AA029N97 | 5mg | $902 |
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | 2372V1TKXK |
| ATC code | B06AC05 |
Lanadelumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0535046 | Lanadelumab 99.74% | 1426055-14-2 | 1mg | $325 | 2026-06-04 | Buy |
| ChemScene | CS-0535046 | Lanadelumab 99.74% | 1426055-14-2 | 5mg | $845 | 2026-06-04 | Buy |
| ChemScene | CS-0535046 | Lanadelumab 99.74% | 1426055-14-2 | 10mg | $1354 | 2026-06-04 | Buy |
| aablocks | AA029N97 | Lanadelumab >98% | 1426055-14-2 | 1mg | $369 | 2026-06-02 | Buy |
| aablocks | AA029N97 | Lanadelumab >98% | 1426055-14-2 | 5mg | $902 | 2026-06-02 | Buy |
Lanadelumab Chemical Properties,Uses,Production
Uses
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema[1][2].
in vivo
Lanadelumab (20 mg/kg; i.v. or s.c.) shows a long half-life of about 12.5 days and blocks high molecular weight kininogen proteolysis in activated plasma in a dose- and time-dependent manner in cynomolgus monkeys[2].
Lanadelumab (1, 30 mg/kg; s.c.) inhibits carrageenan-induced paw edema in the Male Sprague-Dawley rats [2].
References
[1] Riedl MA, et al. Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks. Allergy. 2020 Nov;75(11):2879-2887. DOI:10.1111/all.14416
[2] Kenniston JA, et al. Inhibition of plasma kallikrein by a highly specific active site blocking antibody. J Biol Chem. 2014 Aug 22;289(34):23596-608. DOI:10.1074/jbc.M114.569061
Lanadelumab Preparation Products And Raw materials
Raw materials
Preparation Products
Lanadelumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +86-13382787392 | sales@aeechem.com | China | 10001 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10306 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27602 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7282 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4588 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 15111215862 18229892877 | 3062105966@qq.com | China | 5550 | 58 |
