N2-Methyl-pyridine-2,3-diamine
- CAS No.
- 5028-20-6
- Chemical Name:
- N2-Methyl-pyridine-2,3-diamine
- Synonyms
- IFLAB-BB F2113-0168;2-N-METHYLPYRIDINE-2,3-DIAMINE;N2-Methyl-pyridine-2,3-diamine;2,3-Pyridinediamine, N2-methyl-;N~2~-Methyl-2,3-pyridinediaMine (SALTDATA: FREE)
- CBNumber:
- CB0825265
- Molecular Formula:
- C6H9N3
- Molecular Weight:
- 123.16
- MDL Number:
- MFCD08692132
- MOL File:
- 5028-20-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319-H335-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HazardClass | IRRITANT |
N2-Methyl-pyridine-2,3-diamine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FAA02820 | N2-Methylpyridine-2,3-diamine | 5028-20-6 | 2.5g | $324.5 | 2026-06-04 | Buy |
| Activate Scientific | AS172358 | 2-N-Methylpyridine-2,3-diamine 95% | 5028-20-6 | 1g | $126 | 2026-06-04 | Buy |
| Activate Scientific | AS172358 | 2-N-Methylpyridine-2,3-diamine 95% | 5028-20-6 | 5g | $427 | 2026-06-04 | Buy |
| Matrix Scientific | 293344 | N2-Methylpyridine-2,3-diamine | 5028-20-6 | 250.00mg | $24 | 2026-05-19 | Buy |
| Matrix Scientific | 293344 | N2-Methylpyridine-2,3-diamine | 5028-20-6 | 1.00g | $76 | 2026-05-19 | Buy |
N2-Methyl-pyridine-2,3-diamine Chemical Properties, Uses, Production
Uses
N2-Methylpyridine-2,3-diamine is a useful reagent in synthesis of imidazopyridines, which show tuberculostatic activity.
Synthesis
4093-88-3
5028-20-6
General procedure for the synthesis of N2-methyl-2,3-pyridinediamine from N-methyl-3-nitropyridin-2-amine: N-methyl-3-nitropyridin-2-amine (58.14 g, 0.38 mol) was dissolved in 1,2-dimethoxyethane (400 mL) under vigorous stirring. Activated carbon (2.9 g) was added to the resulting solution, refluxed for 2 hours and left at room temperature overnight. After displacing the reaction system with dry nitrogen, 10% Pd/C catalyst (1.75 g) was added. The mixture was heated to 40 °C and hydrazine monohydrate (54 mL, 1.08 mol) was slowly added dropwise over a period of 2 hours. After dropwise addition, the reaction mixture was refluxed for 2 h. After cooling, the reaction mixture was filtered through a column of diatomaceous earth (upper layer, 3 cm) and silica gel (lower layer, 5 cm, 13 cm diameter) to remove the catalyst. The filtrate layer was washed with 1,2-dimethoxyethane (300 mL). The filtrate was concentrated under reduced pressure to afford N2-methyl-2,3-pyridinediamine in 98% yield (46.2 g) as a brown crystalline solid. The product could be used directly in the subsequent reaction without further purification.
References
[1] Chemistry - A European Journal, 2017, vol. 23, # 57, p. 14173 - 14176
[2] Open Medicinal Chemistry Journal, 2018, vol. 12, # 1, p. 74 - 83
[3] Patent: WO2008/12622, 2008, A2. Location in patent: Page/Page column 57
[4] Patent: CN106831776, 2017, A. Location in patent: Paragraph 0100; 0101; 0102
[5] Patent: WO2012/121936, 2012, A2. Location in patent: Page/Page column 93-94
N2-Methyl-pyridine-2,3-diamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Shanghai Synthfine Chemical Co.,Ltd | 15921303235 | sales@synthfine.com | China | 995 | 58 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Shanghai Fengchen Chem Co., Ltd. | +86 (21) 13764690794 657056093 | sales@shfcchem.com | China | 95 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189;18621755571 | mychess007@163.com | China | 1994 | 55 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9954 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
View Latest Price from N2-Methyl-pyridine-2,3-diamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-03 | N2-METHYL-PYRIDINE-2,3-DIAMINE
5028-20-6
|
$1.00 | 1KG | 95.0-99.8% | 1KG;5KG 10KG; 100KG | Career Henan Chemical Co |
-
- N2-METHYL-PYRIDINE-2,3-DIAMINE
5028-20-6
- $1.00
- 95.0-99.8%
- Career Henan Chemical Co
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