METHYLERGONOVINE
- CAS No.
- 113-42-8
- Chemical Name:
- METHYLERGONOVINE
- Synonyms
- Partergin;Prestwick_727;Methylergosine;Methylergometrin;Methylergobrevin;Methylergobasine;METHYLERGONOVINE;methylergometrine;Methylergonovine-D3;METHYLERGONOVINE USP/EP/BP
- CBNumber:
- CB0833158
- Molecular Formula:
- C20H25N3O2
- Molecular Weight:
- 339.43
- MDL Number:
- MFCD00242879
- MOL File:
- 113-42-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| METHYLERGONOVINE 95.00% | API0006820 | 50MG | $648.83 |
| METHYLERGONOVINE 95.00% | API0006820 | 250MG | $976.27 |
| More product size | |||
| Melting point | 172-173℃ (decomposition) |
|---|---|
| alpha | D20 -45° (c = 0.4 in pyridine) |
| Boiling point | 475.4°C (rough estimate) |
| Density | 1.1492 (rough estimate) |
| refractive index | 1.6650 (estimate) |
| storage temp. | Desiccate at RT |
| pka | pKa 6.65± 0.03(H2O,t =24,I<0.01)(Approximate) |
| color | Prisms from MeOH/Me2CO |
| FDA UNII | W53L6FE61V |
| ATC code | G02AB01 |
SAFETY
Risk and Safety Statements
| Hazardous Substances Data | 113-42-8(Hazardous Substances Data) |
|---|---|
| Toxicity | LD50 orl-rat: 93 mg/kg 27ZIAQ -,163,73 |
METHYLERGONOVINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0006820 | METHYLERGONOVINE 95.00% | 113-42-8 | 50MG | $648.83 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0006820 | METHYLERGONOVINE 95.00% | 113-42-8 | 250MG | $976.27 | 2021-12-16 | Buy |
METHYLERGONOVINE Chemical Properties,Uses,Production
Chemical Properties
Shiny crystals; melts at 172°C (341.6°F);moderately soluble in water, dissolves readilyin alcohol and acetone.
Originator
Methergine,Sandoz,US,1948
Uses
Methylergonovine is a drug currently used as a smooth muscle constrictor during postpartum hemorrhage, as an inhibitor of the inflammasome complex in ASC-mediated procaspase-1 activation screening.
Uses
This compound is a homologue of ergonovine.It is used in the treatment of postpartumhemorrhage.
Uses
Oxytocic.
Definition
ChEBI: (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide is an ergoline alkaloid.
Manufacturing Process
To a freshly prepared solution of 2 parts of d-isolysergic acid azide in 300 parts of either is added an ethereal solution of 2 parts of d-2-aminobutanol-1 and the mixture is left to stand at room temperature during 12 hours. The yellowish clear solution is then washed several times with some water, dried over sodium sulfate and the ether evaporated in vacuo. The crystallized residue is treated with a small quantity of acetone and filtered. Yield: 2.2 parts of d-isolysergic acid-d-1-hydroxybutylamide-2. On recrystallization from
some hot methanol the new compound is obtained in form of beautiful
polygonal crystals that melt with some decomposition at 192° to 194°C
(corr.).
1 part of the iso-compound is then dissolved in 10 parts of absolute ethanol
and an alcoholic potassium hydroxide solution is added thereto. The mixture is
left to stand at room temperature during 45 minutes. After this time
equilibrium is reached between lysergic acid and the isolysergic acid forms,
which can be checked by determination of the constancy of the optical
rotation of the solution. When this point is reached, potassium hydroxide is
transformed into potassium carbonate by bubbling through the solution a
stream of carbon dioxide; the thick crystal paste of potassium carbonate is
then diluted with 50 parts of ether, filtered and washed again with 50 parts of
ether.
The alcoholic ethereal filtrate is then dried over calcined potassium carbonate
and the solution evaporated, whereby 0.9 to 1 part of a mixture of d-lysergic
acid-d-1-hydroxybutylamide-2 and of d-isolysergic acid-d-1-
hydroxybutylamide-2 is obtained. In order to separate the isomers, the
residue is dissolved in 15 parts of hot chloroform and filtered from the small
quantity of inorganic salt, whereby on cooling down, the difficultly soluble
chloroform compound of d-lysergic acid-d-1-hydroxybutylamide-2 crystallizes
out. Yield: 0.4 part. This compound can be recrystallized from hot benzene,
whereby crystals melting with some decomposition at 172°C (corr.) are
obtained. It may then be reacted with maleic acid to give the maleate.
brand name
Methergine(Novartis).
Therapeutic Function
Oxytocic
Health Hazard
The toxic effects due to methylergonovine inhumans include nausea, vomiting, dizziness,and hypertension. The oral and intravenousLD50 values in mice are 187 and 85 mg/kg,respectively.
Biological Activity
Active metabolite of methysergide ; uterotonic agent and oxytocic.
Safety Profile
Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
METHYLERGONOVINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8025 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9484 | 50 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai Zhibang Biological Medicine Co., LTD | 021-54285032 18116461626 | 25493162@qq.com | China | 95 | 58 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-037163312495,13303845143 13303845143 | 3001379618@qq.com | China | 10250 | 58 |
| Nanjing wangzhixing Pharmaceutical Technology Co., Ltd | 18569809817 | 2208093734@qq.com | China | 3978 | 58 |
| Shandong WorldSun Biological Technology Co., Ltd. | 0531-88723173 18596073690 | 1047208234@qq.com | China | 6888 | 58 |
View Lastest Price from METHYLERGONOVINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-16 | Methylergometrine Impurity
113-42-8
|
US $0.00-0.00 / mg | 10mg | 95%+ | 10000000 | Moxin Chemicals | |
 |
2025-06-25 | METHYLERGONOVINE
113-42-8
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd |
-
- Methylergometrine Impurity
113-42-8
- US $0.00-0.00 / mg
- 95%+
- Moxin Chemicals
-
- METHYLERGONOVINE
113-42-8
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
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