L-Arginine, glycyl-L-histidyl-L-arginyl-L-prolyl-L-leucyl-L-α-aspartyl-L-lysyl-L-lysyl-L-arginyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-serylglycylglycylglycyl-L-tyrosyl-
- CAS No.
- 88650-17-3
- Chemical Name:
- L-Arginine, glycyl-L-histidyl-L-arginyl-L-prolyl-L-leucyl-L-α-aspartyl-L-lysyl-L-lysyl-L-arginyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-serylglycylglycylglycyl-L-tyrosyl-
- Synonyms
- FX-06;L-Arginine, glycyl-L-histidyl-L-arginyl-L-prolyl-L-leucyl-L-α-aspartyl-L-lysyl-L-lysyl-L-arginyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-serylglycylglycylglycyl-L-tyrosyl-
- CBNumber:
- CB08366047
- Molecular Formula:
- C133H216N44O38
- Molecular Weight:
- 3039.41
- MDL Number:
- MOL File:
- 88650-17-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
L-Arginine, glycyl-L-histidyl-L-arginyl-L-prolyl-L-leucyl-L-α-aspartyl-L-lysyl-L-lysyl-L-arginyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-serylglycylglycylglycyl-L-tyrosyl- Properties
| Density | 1.54±0.1 g/cm3(Predicted) |
|---|---|
| form | Solid |
| color | White to off-white |
| FDA UNII | A4M8648R4L |
L-Arginine, glycyl-L-histidyl-L-arginyl-L-prolyl-L-leucyl-L-α-aspartyl-L-lysyl-L-lysyl-L-arginyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-serylglycylglycylglycyl-L-tyrosyl- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0025490 | FX-06 99.98% | 88650-17-3 | 1mg | $54 | 2026-06-04 | Buy |
| ChemScene | CS-0025490 | FX-06 99.98% | 88650-17-3 | 5mg | $139 | 2026-06-04 | Buy |
| ChemScene | CS-0025490 | FX-06 99.98% | 88650-17-3 | 10mg | $217 | 2026-06-04 | Buy |
| aablocks | AA02APTO | FIBRIN-DERIVED PEPTIDE B.BETA.15-42 >98% | 88650-17-3 | 1mg | $108 | 2026-06-02 | Buy |
| aablocks | AA02APTO | FIBRIN-DERIVED PEPTIDE B.BETA.15-42 >98% | 88650-17-3 | 5mg | $213 | 2026-06-02 | Buy |
L-Arginine, glycyl-L-histidyl-L-arginyl-L-prolyl-L-leucyl-L-α-aspartyl-L-lysyl-L-lysyl-L-arginyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-serylglycylglycylglycyl-L-tyrosyl- Chemical Properties, Uses, Production
Uses
FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS)[1][2][4].
in vivo
FX06 (2.4 mg/kg, i.v. bolus) shows significantly improved pulmonary and circulatory function in a pig model of hemorrhagic shock and reperfusion[3].
FX06 (2.4 mg/kg, i.p., twice daily) improves survival and reduces capillary leak in mice with Dengue-induced shock[4].
FX06 (3.6 mg/kg, i.v.) protects mice from Ischemia/reperfusion (I/R)-induced kidney injury by aiding in epithelial cell proliferation and tissue repair[5].
| Animal Model: | Pig model of hemorrhagic shock and reperfusion [3] |
| Dosage: | 2.4 mg/kg |
| Administration: | Intravenous injection (i.v.) bolus |
| Result: | Reduced raccumulation of myeloperoxidase-pos. cells (mainly neutrophils) in myocardium, liver, and small intestine, and reduced interleukin-6 plasma levels. |
| Animal Model: | Mice with Dengue-induced shock[4] |
| Dosage: | 2.4 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Significantly improved survival rates, reduced capillary leak within lungs and the intestine, and reduced hemoconcentration and fibrinogen consumption. |
References
[1] Ahrens I, et al. FX-06, a fibrin-derived Bbeta15-42 peptide for the potential treatment of reperfusion injury following myocardial infarction. Curr Opin Investig Drugs. 2009 Sep;10(9):997-1003. PMID:19705343
[2] Zou F, et al. Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening. Bioorg Med Chem Lett. 2018 Feb 1;28(3):388-393. DOI:10.1016/j.bmcl.2017.12.030
[3] Roesner JP, et al. Bbeta15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion. Crit Care Med. 2009 Feb;37(2):598-605. DOI:10.1097/CCM.0b013e3181959a12
[4] Grger M, et al. Peptide Bbeta(15-42) preserves endothelial barrier function in shock. PLoS One. 2009;4(4):e5391. DOI:10.1371/journal.pone.0005391
[5] Aparna Krishnamoorthy, et al. Fibrinogen β–derived Bβ15-42 peptide protects against kidney ischemia/ reperfusion injury. Blood (2011) 118 (7): 1934–1942.
L-Arginine, glycyl-L-histidyl-L-arginyl-L-prolyl-L-leucyl-L-α-aspartyl-L-lysyl-L-lysyl-L-arginyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-serylglycylglycylglycyl-L-tyrosyl- Preparation Products And Raw materials
Raw materials
Preparation Products
L-Arginine, glycyl-L-histidyl-L-arginyl-L-prolyl-L-leucyl-L-α-aspartyl-L-lysyl-L-lysyl-L-arginyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-serylglycylglycylglycyl-L-tyrosyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2436 | 58 |
| Hubei Weideli Chemical Reagent Co., Ltd. | 15871722230 | 15871722230@163.com | China | 4442 | 58 |
| Shanghai HongTide Biotechnology Co.,Ltd. | 15318089928 | alex@hanhonggroup.com | China | 4604 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| YantaiBio | 13758194781; 13758194781 | 764619768@qq.com | China | 1755 | 58 |
| Fuan Bio | 15002819872 | 2845971812@qq.com | China | 2103 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
