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ChemicalBook >> CAS DataBase List >>1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- Structure
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- structure
CAS No.
40313-92-6
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl-
Synonyms
Thalidomide-5-methyl;Thalidomide-5-methyl, 10 mM in DMSO;2-(2,6-Dioxo-3-piperidyl)-5-methylisoindoline-1,3-dione;2-(2,6-Dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl-;2-(2,6-dioxopiperidin-3-yl)-5-methyl-2,3-dihydro-1 H-isoindole-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-5-methyl-1H-isoindole-1,3(2H)-dione - [AC79949];Thalidomide 5 methyl,inhibit,E3 ligase-recruiting Moiety,Thalidomide5methyl,Ligands for E3 Ligase,Inhibitor
CBNumber:
CB08370684
Molecular Formula:
C14H12N2O4
Molecular Weight:
272.26
MDL Number:
MOL File:
40313-92-6.mol
Last updated:2025-06-22 21:37:49
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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- Properties

Melting point 265.5-267.5 °C(Solv: methanol (67-56-1))
Boiling point 531.6±50.0 °C(Predicted)
Density 1.448±0.06 g/cm3(Predicted)
pka 10.73±0.40(Predicted)
form Solid
color Gray to gray purple

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- Chemical Properties,Uses,Production

Uses

Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1].

IC 50

Cereblon

References

[1] George W. Muller, et al. Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels. Patent US5874448A.

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Alfa Chemistry 		+1-5166625404; Info@alfa-chemistry.com United States 20405 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38838 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 1014988033@qq.com China 4913 55
Amatek Scientific Co. Ltd. 0512-56316828 info@amateksci.com China 28787 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-025-85560043 17301488900 info@synzest.com China 9286 58
Shandong Territorial sea Biological Technology Co., LTD 15092083467 18660263263@163.com China 2774 58
Hefei Mokai Pharmaceutical Technology Co., Ltd 18130062233 3362556465@qq.com China 8100 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62320 58
Nanjing Shizhou Biology Technology Co.,Ltd 18351873721 helen.zhang@synzest.com China 8295 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Alfa Chemistry 		58
TargetMol Chemicals Inc. 		58
MQ (shanghai) Pharmaceuticals Co., Ltd. 55
Amatek Scientific Co. Ltd. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Shandong Territorial sea Biological Technology Co., LTD 58
Hefei Mokai Pharmaceutical Technology Co., Ltd 58
Bide Pharmatech Ltd. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

View Lastest Price from 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thalidomide-5-methyl pictures 2025-06-22 Thalidomide-5-methyl
40313-92-6
 US $90.00-333.00 / mg 99.48% 10g TargetMol Chemicals Inc.
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- 2-(2,6-Dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-methyl-2,3-dihydro-1 H-isoindole-1,3-dione Thalidomide-5-methyl Thalidomide 5 methyl,inhibit,E3 ligase-recruiting Moiety,Thalidomide5methyl,Ligands for E3 Ligase,Inhibitor Thalidomide-5-methyl, 10 mM in DMSO 2-(2,6-Dioxo-3-piperidyl)-5-methylisoindoline-1,3-dione 2-(2,6-Dioxo-3-piperidinyl)-5-methyl-1H-isoindole-1,3(2H)-dione - [AC79949] 40313-92-6