Nalmefene hydrochloride
- CAS No.
- 58895-64-0
- Chemical Name:
- Nalmefene hydrochloride
- Synonyms
- Revex;NALMEFENE HCL;Unii-K7K69qc05x;Nalmefene Impurity 2;nalmefene hydrochloride;Nalmefene Hydrochloride IMP;Nalmefene Hydrochloride Impurity;(5a)-17-(CyclopropylMethyl)-6-Methylene-4,5-epoxyMorphinan-3,14-diol;(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diolhydrochloride;17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
- CBNumber:
- CB0855103
- Molecular Formula:
- C21H26ClNO3
- Molecular Weight:
- 375.89
- MDL Number:
- MFCD27937056
- MOL File:
- 58895-64-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 180-185° |
|---|---|
| storage temp. | Desiccate at RT |
| solubility | Soluble in Water (up to 25 mg/ml). |
| form | solid |
| pka | 7.63(at 25℃) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
| InChIKey | GYWMRGWFQPSQLK-GGPQROQHNA-N |
| SMILES | O[C@]12CCC(=C)[C@]3([H])OC4C(=CC=C5C[C@@]1([H])N(CC1CC1)CC[C@@]23C=45)O.Cl |&1:1,6,15,24,r| |
| CAS DataBase Reference | 58895-64-0 |
| FDA UNII | K7K69QC05X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H312-H317-H302-H332-H334 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P261-P285-P304+P341-P342+P311-P501 |
Nalmefene hydrochloride price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2956 | Nalmefene Hydrochloride ≥98% (HPLC) | 58895-64-0 | 10 mg | $104 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2956 | Nalmefene Hydrochloride ≥98% (HPLC) | 58895-64-0 | 50 mg | $420 | 2026-04-30 | Buy |
| Cayman Chemical | 28266 | Nalmefene (hydrochloride) ≥98% | 58895-64-0 | 10mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 28266 | Nalmefene (hydrochloride) ≥98% | 58895-64-0 | 25mg | $65 | 2026-04-30 | Buy |
| Cayman Chemical | 28266 | Nalmefene (hydrochloride) ≥98% | 58895-64-0 | 50mg | $97 | 2026-04-30 | Buy |
Nalmefene hydrochloride Chemical Properties, Uses, Production
Description
Nalmefene hydrochloride has been introduced in the U.S.A. for opioid reversal following surgery, and in the reversal of opioid overdoses and epidurally administered narcotics. Nalmefene is an opioid antagonist that inhibits respiratory, analgesic and subjective effects of opioids. It has a higher potency, a longer duration of action, and superior bioavailability than the structurally related naltrexone. Nalmefene has a wide spectrum of biological activity and is in clinical trials for the treatment of interstitial cystitis, recalcitrant pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS trauma, and alcoholism. Studies indicate that nalmefene does not induce morphine-like effects and has no apparent abuse potential.
Originator
IVAX (U.S.A.)
Uses
Nalmefene Hydrochloride is a structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist
brand name
Revex
storage
Desiccate at RT
References
[1] MELISSA D. OSBORN . In vivo characterization of the opioid antagonist nalmefene in mice[J]. Life sciences, 2010, 86 15: Pages 624-630. DOI:10.1016/j.lfs.2010.02.013
[2] EDUARDO R BUTELMAN. Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 328 2: 588-597. DOI:10.1124/jpet.108.145342
[3] EDUARDO R BUTELMAN. The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates.[J]. Journal of Pharmacology and Experimental Therapeutics, 2008, 327 1: 154-160. DOI:10.1124/jpet.108.140079
[4] MICHAEL SOYKA Susanne R. Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review.[J]. Current drug abuse reviews, 2008, 1 3: 280-291. DOI:10.2174/1874473710801030280
Nalmefene hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | 029-81024372 17792795018 | 1053@dideu.com | China | 9999 | 58 |
| Nanjing hongshenghuo Biotechnology Co., Ltd | 025-58311670 18020159086 | 54604129@qq.com | China | 185 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Hunan Furui Biopharma Technology Co., Ltd. | 15901640172，19275032510 15901640172 | sales03@hn-furui.com | China | 380 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
View Latest Price from Nalmefene hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-11-16 | Nalmefene hydrochloride
58895-64-0
|
$35.00 | 1KG | 99% | 20 Tons | Longyan Tianhua Biological Technology Co., Ltd | |
 |
2019-07-06 | Nalmefene hydrochloride
58895-64-0
|
$2.00 | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- Nalmefene hydrochloride
58895-64-0
- $35.00
- 99%
- Longyan Tianhua Biological Technology Co., Ltd
-
- Nalmefene hydrochloride
58895-64-0
- $2.00
- 99%
- Career Henan Chemical Co
