5-Fluoro-2-methoxyaniline
- CAS No.
- 1978-39-8
- Chemical Name:
- 5-Fluoro-2-methoxyaniline
- Synonyms
- 5-fluoro-o-anisidine;2-amino-4-fluoroanisole;5-Fluoro-2-methoxyaniline;5-Fluoro-o-anisidine (NH2=1);5-fluoro-2-methoxybenzenamine;5-Fluoro-2-methoxyaniline 97%;5-Fluoro-2-methoxyaniline, JRD;BenzenaMine,5-fluoro-2-Methoxy-;2-amino-4-fluoro-1-methoxybenzene;2-Amino-4-fluoroanisole, 5-Fluoro-o-anisidine
- CBNumber:
- CB0967598
- Molecular Formula:
- C7H8FNO
- Molecular Weight:
- 141.14
- MDL Number:
- MFCD00077537
- MOL File:
- 1978-39-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 3 °C |
|---|---|
| Boiling point | 90 °C/760 mmHg |
| Density | 1.1981 g/mL at 25 °C |
| refractive index | n20/D 1.5438 |
| Flash point | 109 °C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 3.52±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| InChI | 1S/C7H8FNO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,9H2,1H3 |
| InChIKey | VYZUBHRSGQAROM-UHFFFAOYSA-N |
| SMILES | COc1ccc(F)cc1N |
| CAS DataBase Reference | 1978-39-8 |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H311-H373-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P280h-P302+P352-P309-P310-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN 2810 6.1/PG III | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2921420090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
5-Fluoro-2-methoxyaniline price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 683310 | 5-Fluoro-2-methoxyaniline 97% | 1978-39-8 | 1g | $49.7 | 2023-06-20 | Buy |
| TCI Chemical | F0614 | 5-Fluoro-2-methoxyaniline >98.0%(GC)(T) | 1978-39-8 | 5g | $61 | 2026-04-30 | Buy |
| Usbiological | 276625 | 5-Fluoro-2-methoxyaniline Asreported | 1978-39-8 | 1g | $333 | 2026-06-03 | Buy |
| Usbiological | 276625 | 5-Fluoro-2-methoxyaniline Asreported | 1978-39-8 | 2g | $453 | 2026-06-03 | Buy |
| Usbiological | 276625 | 5-Fluoro-2-methoxyaniline Asreported | 1978-39-8 | 5g | $588 | 2026-06-03 | Buy |
5-Fluoro-2-methoxyaniline Chemical Properties, Uses, Production
Uses
5-Fluoro-2-methoxyaniline was used in the study of structure-activity relationship to discover selective inhibitors of p97 ATPase.
Synthesis
445-83-0
1978-39-8
General procedure for the synthesis of 2-methoxy-5-fluoroaniline from 2-nitro-4-fluoroanisole: 4-fluoro-2-nitroanisole (85 g, 0.50 mol) was dissolved in methanol (300 mL) and palladium-carbon catalyst (10%, 8 g) was added. The reaction was stirred under hydrogen atmosphere for 15 hours. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was concentrated to dryness to obtain the crude product 2-methoxy-5-fluoroaniline (61.5 g, 0.436 mol, 87% yield), which could be directly used in the next reaction without further purification.
References
[1] Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 1, p. 72 - 87
[2] Patent: WO2005/26137, 2005, A2. Location in patent: Page/Page column 231
[3] Journal of Organic Chemistry, 1951, vol. 16, p. 1345,1348
[4] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[5] Journal of Organic Chemistry, 1952, vol. 17, p. 229,230
5-Fluoro-2-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUXI SHUANGQI TECHNOLOGY CO LTD. | 18114865355 18055643310 | 1702606491@qq.com | China | 1104 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 5-Fluoro-2-methoxyaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 5-Fluoro-o-anisidine
1978-39-8
|
$1.00-50.00 | 1kg | 99 | Henan Fengda Chemical Co., Ltd | ||
 |
2026-03-20 | 5-Fluoro-2-methoxyaniline
1978-39-8
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2026-02-02 | 5-Fluoro-2-methoxyaniline
1978-39-8
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 5-Fluoro-o-anisidine
1978-39-8
- $1.00-50.00
- 99
- Henan Fengda Chemical Co., Ltd
-
- 5-Fluoro-2-methoxyaniline
1978-39-8
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Fluoro-2-methoxyaniline
1978-39-8
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
