ChemicalBook >> CAS DataBase List >>1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester
1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester
![1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester Structure](CAS/20210305/GIF/1860297-13-7.gif)
- CAS No.
- 1860297-13-7
- Chemical Name:
- 1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester
- Synonyms
- 2-((4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)methyl)oxazole-4-carboxylic acid;2-({4-[(tert-butoxy)carbonyl]-1,4-diazepan-1-yl}methyl)-1,3-oxazole-4-carboxylic acid;1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester
- CBNumber:
- CB09786408
- Molecular Formula:
- C15H23N3O5
- Molecular Weight:
- 325.36
- MDL Number:
- MOL File:
- 1860297-13-7.mol
Last updated:2026-01-13 11:13:24
1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester Properties
| Boiling point | 464.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.249±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | powder |
| pka | 3.20±0.10(Predicted) |
| InChI | 1S/C15H23N3O5/c1-15(2,3)23-14(21)18-6-4-5-17(7-8-18)9-12-16-11(10-22-12)13(19)20/h10H,4-9H2,1-3H3,(H,19,20) |
| InChIKey | ISKRFCHVIQJQMO-UHFFFAOYSA-N |
| SMILES | CC(C)(OC(N1CCCN(CC1)CC2=NC(C(O)=O)=CO2)=O)C |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester Chemical Properties, Uses, Production
Uses
2-((4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)methyl)oxazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920517
920681
reaction suitability
reagent type: linker
1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester Preparation Products And Raw materials
Raw materials
Preparation Products
1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester Suppliers
Global Suppliers ( 2)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1644 | 58 |
| Supplier | Advantage |
|---|---|
| Jilin Province Woda Biotechnology Co., Ltd. | 58 |
1H-1,4-Diazepine-1-carboxylic acid, 4-[(4-carboxy-2-oxazolyl)methyl]hexahydro-, 1-(1,1-dimethylethyl) ester
2-({4-[(tert-butoxy)carbonyl]-1,4-diazepan-1-yl}methyl)-1,3-oxazole-4-carboxylic acid
2-((4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)methyl)oxazole-4-carboxylic acid
1860297-13-7
