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5-Bromo-2-methoxy-4-methyl-3-nitropyridine

5-Bromo-2-methoxy-4-methyl-3-nitropyridine structure

CAS No.: 884495-14-1

Chemical Name:: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine

Synonyms: 5-Bromo-2-methoxy-3-nitro-4-picoline;SKL432;5-BroMo-2-Methoxy-4-Methyl-3-nitropyridin;2-Methoxy-3-nitro-4-methyl-5-Bromopyridine;5-Bromo-2-methoxy-4-methyl-3-nitropyridine;2-METHOXY-3-NITRO-5-BROMO-4-METHYLPYRIDINE;5-Bromo-2-methoxy-4-methy1-3-aitropyridine;5-Bromo-2-methoxy-4-methyl-3-nitropyridine-3;Pyridine, 5-broMo-2-Methoxy-4-Methyl-3-nitro-;5-Bromo-2-methoxy-4-methyl-3-nitropyridine≥ 99% (HPLC)

CBNumber:: CB11012650

Molecular Formula:: C7H7BrN2O3

Molecular Weight:: 247.05

MDL Number:: MFCD06659504

MOL File:: 884495-14-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:00:38

Product description	Number	Pack Size	Price
5-Bromo-2-methoxy-4-methyl-3-nitropyridine ≥95%	OR41181	1g	$21
5-Bromo-2-methoxy-4-methyl-3-nitropyridine ≥95%	OR41181	5g	$55
5-Bromo-2-methoxy-3-nitro-4-picoline 98%(GC)	X6614	1g	$16
5-Bromo-2-methoxy-3-nitro-4-picoline 98%(GC)	X6614	5g	$24
5-Bromo-2-methoxy-3-nitro-4-picoline 98%(GC)	X6614	25g	$65
More product size

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5-Bromo-2-methoxy-4-methyl-3-nitropyridine Properties

Boiling point	302.8±37.0 °C(Predicted)
Density	1.636±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Dichloromethane, Ethyl Acetate
pka	-2.34±0.28(Predicted)
form	Solid
color	Light Yellow
InChI	InChI=1S/C7H7BrN2O3/c1-4-5(8)3-9-7(13-2)6(4)10(11)12/h3H,1-2H3
InChIKey	BGDKJBCVNNWITN-UHFFFAOYSA-N
SMILES	C1(OC)=NC=C(Br)C(C)=C1[N+]([O-])=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933399990

5-Bromo-2-methoxy-4-methyl-3-nitropyridine price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR41181	5-Bromo-2-methoxy-4-methyl-3-nitropyridine ≥95%	884495-14-1	1g	$21	2026-06-04	Buy
Apolloscientific	OR41181	5-Bromo-2-methoxy-4-methyl-3-nitropyridine ≥95%	884495-14-1	5g	$55	2026-06-04	Buy
AK Scientific	X6614	5-Bromo-2-methoxy-3-nitro-4-picoline 98%(GC)	884495-14-1	1g	$16	2026-06-04	Buy
AK Scientific	X6614	5-Bromo-2-methoxy-3-nitro-4-picoline 98%(GC)	884495-14-1	5g	$24	2026-06-04	Buy
AK Scientific	X6614	5-Bromo-2-methoxy-3-nitro-4-picoline 98%(GC)	884495-14-1	25g	$65	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR41181	1g	$21	Buy
OR41181	5g	$55	Buy
X6614	1g	$16	Buy
X6614	5g	$24	Buy
X6614	25g	$65	Buy

5-Bromo-2-methoxy-4-methyl-3-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Solid

Uses

5-Bromo-2-methoxy-4-methyl-3-nitropyridine (BMN) is a chemical compound with anticancer activity. BMN inhibits tumor growth by binding to the bromodomain, which is found in many proteins that regulate cell division and DNA repair.

Synthesis

160590-36-3

884495-14-1

The general procedure for the synthesis of 5-bromo-2-methoxy-4-methyl-3-nitropyridine using 2-methoxy-3-nitro-4-methylpyridine as starting material was as follows: sodium acetate (365 g, 5.37 mol) was slowly added to a stirring solution of 2-methoxy-4-methyl-3-nitropyridine (250 g, 1.49 mol) in acetic acid (1.5 L) at room temperature. Subsequently, bromine (Br2, 639 g, 4.00 mol) was added dropwise and the dropwise addition time was controlled to be less than 30 minutes. After addition, the reaction mixture was warmed up to 80 °C for 12 h, during which the progress of the reaction was monitored by thin-layer chromatography (TLC) to confirm that the reaction was complete. Upon completion of the reaction, the mixture was cooled to 0 °C and 10% aqueous solution (1.5 L) and saturated aqueous sodium sulfate solution (1.5 L) were added sequentially to quench the reaction. The resulting solid product was collected by filtration, washed with water, and then dried under reduced pressure to finally obtain 5-bromo-2-methoxy-4-methyl-3-nitropyridine (302 g, 82.2% yield) as a light yellow solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.25 (s, 1H), 3.94 (s, 3H), 2.29 (s, 3H).

References

[1] Patent: WO2016/77378, 2016, A1. Location in patent: Page/Page column 85; 86; 157; 158; 163; 164
[2] Patent: WO2016/77380, 2016, A1. Location in patent: Page/Page column 63; 64
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5391 - 5402
[4] Patent: WO2016/77375, 2016, A1. Location in patent: Page/Page column 79-80
[5] Patent: WO2016/123391, 2016, A1. Location in patent: Page/Page column 76; 77; 185; 186

5-Bromo-2-methoxy-4-methyl-3-nitropyridine synthesis

Synthesis of 5-Bromo-2-methoxy-4-methyl-3-nitropyridine from 2-Amino-5-bromo-4-methyl-3-nitropyridine

5-Bromo-2-methoxy-4-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-bromo-4-methyl-3-nitropyridine 2-METHOXY-3-NITRO-4-PICOLINE

Preparation Products

4-bromo-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one ABBV-075 5-broMo-4-Methyl-2-(Methyloxy)-3-pyridinaMine

5-Bromo-2-methoxy-4-methyl-3-nitropyridine Suppliers

Global( 214)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Laing Biotechnology Co.,Ltd	+86-13004516015 +86-18149392822	christina@laingbiotec.com	China	777	58
Shanghai Scochem Technology Co., Ltd	+86-021-33758897 +86-13701882790	sales@scochem.com	China	1977	58
Nanjing New Thinking Chem Co.,Ltd	+8615896017193	nanjingxinsi@163.com	China	217	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58

Supplier	Advantage
Suzhou Laing Biotechnology Co.,Ltd	58
Shanghai Scochem Technology Co., Ltd	58
Nanjing New Thinking Chem Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Shanghai Arbor Chemical Co., Ltd.	58
Jinan Carbotang Biotech Co.,Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Accela ChemBio Inc.	58

View Lastest Price from 5-Bromo-2-methoxy-4-methyl-3-nitropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-02	5-Bromo-2-methoxy-4-methyl-3-nitropyridine 884495-14-1	$1.00	1g	98%	50tons	Shaanxi Dideu Medichem Co. Ltd
2025-12-01	5-Bromo-2-methoxy-4-methyl-3-nitropyridine 884495-14-1		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-11-18	5-Bromo-2-methoxy-4-methyl-3-nitropyridine 884495-14-1	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited

5-Bromo-2-methoxy-4-methyl-3-nitropyridine
884495-14-1
$1.00
98%
Shaanxi Dideu Medichem Co. Ltd

5-Bromo-2-methoxy-4-methyl-3-nitropyridine
884495-14-1
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

5-Bromo-2-methoxy-4-methyl-3-nitropyridine
884495-14-1
$1.10
99.00%
Dideu Industries Group Limited

5-Bromo-2-methoxy-4-methyl-3-nitropyridine Spectrum

5-Bromo-2-methoxy-4-methyl-3-nitropyridine(884495-14-1)¹HNMR

884495-14-1(5-Bromo-2-methoxy-4-methyl-3-nitropyridine)Related Search:

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5-Bromo-2-methoxy-4-methyl-3-nitropyridine 5-BroMo-2-Methoxy-4-Methyl-3-nitropyridin 5-Bromo-2-methoxy-4-methyl-3-nitropyridine-3 Pyridine, 5-broMo-2-Methoxy-4-Methyl-3-nitro- 2-METHOXY-3-NITRO-5-BROMO-4-METHYLPYRIDINE 5-Bromo-2-methoxy-4-methyl-3-nitropyridine≥ 99% (HPLC) 2-Methoxy-3-nitro-4-methyl-5-Bromopyridine 5-Bromo-2-methoxy-4-methyl-3-nitropyridine ISO 9001：2015 REACH SKL432 5-Bromo-2-methoxy-4-methy1-3-aitropyridine 5-Bromo-2-methoxy-3-nitro-4-picoline 884495-14-1 C7H7BrN2O3 Pyridine Series Aromatics Heterocycles CHIRAL CHEMICALS