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ChemicalBook >> CAS DataBase List >>Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester

Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester

Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester Structure
Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester structure
CAS No.
329716-61-2
Chemical Name:
Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester
Synonyms
J115814;J-115814;UNII-81DP93CF8M;J 115814J-115814;Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester
CBNumber:
CB110402462
Molecular Formula:
C29H38ClN5O3S
Molecular Weight:
572.16
MDL Number:
MOL File:
329716-61-2.mol
Last updated:2025-04-18 09:51:34
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Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester Properties

Boiling point 692.9±55.0 °C(Predicted)
Density 1.261±0.06 g/cm3(Predicted)
pka 12.93±0.70(Predicted)
FDA UNII 81DP93CF8M

Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester Chemical Properties,Uses,Production

Uses

J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors[1].

in vivo

J-115814 (0.3, 1, 3, 10 mg/kg; i.v.) inhibits NPY-induced feeding in SD rats[1].
J-115814 (3, 10, 30 mg/kg; i.p.) shows anorexigenic effect in mice[1].

Animal Model:db/db and lean C57BL6 mice[1]
Dosage:3, 10, 30 mg/kg
Administration:I.p.
Result:Decreasesd nocturnal food intake in a dose-dependent manner.
Animal Model:SD rats[1]
Dosage:0.3, 1, 3, 10 mg/kg
Administration:I.v.; 1 h before ICV NPY
Result:Inhibited NPY-induced feeding with significant responses at 3 and 10 mg/kg.

IC 50

hY1 receptor: 1.4 nM (Ki); rNPY Y1 receptor: 1.8 nM (Ki); mY1: 1.9 nM (Ki); hY4 receptor: 620 nM (Ki); hY5 receptor: 6000 nM (Ki); human Y2 receptor: >10000 nM (Ki); mY6: >10000 nM (Ki)

References

[1] Kanatani A, et al. A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Mol Pharmacol. 2001 Mar;59(3):501-5. DOI:10.1124/mol.59.3.501

Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester Suppliers

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Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester J 115814J-115814 J115814 J-115814 UNII-81DP93CF8M 329716-61-2