Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:)
![Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:) Structure](CAS/20211123/GIF/1103508-80-0.gif)
- CAS No.
- 1103508-80-0
- Chemical Name:
- Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:)
- Synonyms
- Tepotinib hydrochloride(1 : x);Tepotinib hydrochloride(1 : x), 10 mM in DMSO;Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:)
- CBNumber:
- CB110406804
- Molecular Formula:
- C29H29ClN6O2
- Molecular Weight:
- 529.04
- MDL Number:
- MOL File:
- 1103508-80-0.mol
- MSDS File:
- SDS
Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:) Properties
| FDA UNII | 8B73AZL5XP |
|---|
Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA02C8QC | Tepotinib hydrochloride(1 : x) | 1103508-80-0 | 1mg | $237 | 2026-06-02 | Buy |
| aablocks | AA02C8QC | Tepotinib hydrochloride(1 : x) | 1103508-80-0 | 5mg | $512 | 2026-06-02 | Buy |
| aablocks | AA02C8QC | Tepotinib hydrochloride(1 : x) | 1103508-80-0 | 10mg | $750 | 2026-06-02 | Buy |
| aablocks | AA02C8QC | Tepotinib hydrochloride(1 : x) | 1103508-80-0 | 25mg | $1186 | 2026-06-02 | Buy |
Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:) Chemical Properties, Uses, Production
Uses
Tepotinib (EMD-1214063) hydrochloride is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC50 of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib hydrochloride inhibits c-Met phosphorylation and induces autophagy. Tepotinib hydrochloride has antitumor effects[1][2][3].
in vivo
Tepotinib hydrochloride induces tumor regression in xenograft models and inhibits in vivo c-Met phosphorylation[1].
| Animal Model: | CD-1 or BALB/C nude mice bearing human cancer cell lines KP-4, or EBC-1[1] |
| Dosage: | 6 and 15 mg/kg for mice bearing NSCLC EBC-1; 25, 50 and 200 mg/kg for mice bearing pancreatic carcinoma cell line KP-4. |
| Administration: | Injected daily; for 14-18 days |
| Result: | Daily administration of 5 or 15 mg/kg to EBC-1 tumor-bearing mice resulted in effective inhibition or complete tumor regression, respectively. Induced dose-dependent tumor growth inhibition in mice bearing human pancreatic carcinoma KP-4 tumors. |
References
[1] Bladt F, et al. EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clin Cancer Res, 2013, 19(11), 2941-2951. DOI:10.1158/1078-0432.CCR-12-3247
[2] Zhan N, et al. The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, β-Catenin-Mutated Mouse Model. Gene Expr. 2018 May 18;18(2):135-147. DOI:10.3727/105221618X15174108894682
[3] A. Naing, et al. IS4-1 - A Phase I Dose-Escalation Study of emd 1214063, an Oral Selective CMET Inhibitor, in Patients with Advanced Solid Tumors. Annals of Oncology. Volume 23, Supplement 11, October 2012, Page xi21.
Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:) Preparation Products And Raw materials
Raw materials
Preparation Products
Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Chongqing jooe co., ltd | +86-15223382610 | info@jooe.com | China | 15930 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Latest Price from Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-, hydrochloride (1:) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Tepotinib hydrochloride(1 : x)
1103508-80-0
|
$148.00-497.00 | 99.81% | 10g | TargetMol Chemicals Inc. |
-
- Tepotinib hydrochloride(1 : x)
1103508-80-0
- $148.00-497.00
- 99.81%
- TargetMol Chemicals Inc.
