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Diethyl squarate

Diethyl squarate structure

CAS No.: 5231-87-8

Chemical Name:: Diethyl squarate

Synonyms: DIETHYL SQUARATE;3,4-DiethoxycycL;DIETHYL SUQUARATE;DiethylSquarate98%;Diethyl quadratate;TIMTEC-BB SBB008498;obut-3-ene-1,2-dione;DIETHOXYCYCLOBUTENEDIONE;SQUARIC ACID DIETHYL ESTER;SUQUARIC ACID DIETHYL ESTER

CBNumber:: CB1106356

Molecular Formula:: C8H10O4

Molecular Weight:: 170.16

MDL Number:: MFCD00001333

MOL File:: 5231-87-8.mol

MSDS File:: SDS

Last updated:2026-01-13 11:14:01

Product description	Number	Pack Size	Price
3,4-Diethoxy-3-cyclobutene-1,2-dione 98%	310778	5g	$145
3,4-Diethoxy-3-cyclobutene-1,2-dione >98.0%(GC)	D3253	5g	$64
3,4-Diethoxy-3-cyclobutene-1,2-dione >98.0%(GC)	D3253	25g	$202
3,4-Diethoxy-3-cyclobutene-1,2-dione	074283	1.00g	$59
3,4-Diethoxy-3-cyclobutene-1,2-dione	074283	5.00g	$151
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Diethyl squarate Properties

Melting point	13-18 °C
Boiling point	95 °C0.1 mm Hg(lit.)
Density	1.15 g/mL at 25 °C(lit.)
refractive index	n20/D 1.509(lit.)
Flash point	>230 °F
storage temp.	2-8°C
form	Liquid
color	Clear yellow to light brownish
Water Solubility	insoluble
BRN	640626
InChI	1S/C8H10O4/c1-3-11-7-5(9)6(10)8(7)12-4-2/h3-4H2,1-2H3
InChIKey	DFSFLZCLKYZYRD-UHFFFAOYSA-N
SMILES	CCOC1=C(OCC)C(=O)C1=O
CAS DataBase Reference	5231-87-8(CAS DataBase Reference)
EWG's Food Scores	1
NIST Chemistry Reference	3,4-Diethoxy-3-cyclobutene-1,2-dione(5231-87-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H315-H317-H319-H334-H335

Precautionary statements

P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

36/37/38-42/43

Safety Statements

7-26-37/39-24-23

WGK Germany

RTECS

GU1772466

Hazard Note

Irritant

HS Code

29145090

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3

NFPA 704

	1
2		0

Diethyl squarate price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	310778	3,4-Diethoxy-3-cyclobutene-1,2-dione 98%	5231-87-8	5g	$145	2026-04-30	Buy
TCI Chemical	D3253	3,4-Diethoxy-3-cyclobutene-1,2-dione >98.0%(GC)	5231-87-8	5g	$64	2026-04-30	Buy
TCI Chemical	D3253	3,4-Diethoxy-3-cyclobutene-1,2-dione >98.0%(GC)	5231-87-8	25g	$202	2026-04-30	Buy
Matrix Scientific	074283	3,4-Diethoxy-3-cyclobutene-1,2-dione	5231-87-8	1.00g	$59	2026-05-18	Buy
Matrix Scientific	074283	3,4-Diethoxy-3-cyclobutene-1,2-dione	5231-87-8	5.00g	$151	2026-05-18	Buy

Product number	Packaging	Price	Buy
310778	5g	$145	Buy
D3253	5g	$64	Buy
D3253	25g	$202	Buy
074283	1.00g	$59	Buy
074283	5.00g	$151	Buy

Diethyl squarate Chemical Properties,Uses,Production

Chemical Properties

clear yellow to light brownish liquid

Uses

Diethyl squarate is an intermediate for pharma products, for photochemicals used in the dry-view process, in synthesis of photosensitive squaraine dyes (eg. laser dyes used in CD-Rom) and as intermediate for functional polymers.

Uses

3,4-Dethoxy-3-cyclobutene-1,2-dione is used as a starting material for synthesis of furanones and quinones. It undergoes ethoxy substitution with amines and unsaturated organosilanes.

General Description

The reaction of 3,4-diethoxy-3-cyclobutene-1,2-dione (squaric acid diethyl ester) with glycosylamines (formed by reducing oligosaccharides) was studied. The derivatives formed were linked to amino-functionalized lipids, solids or proteins.

Synthesis

64-17-5

2892-51-5

5231-87-8

1. Squaric acid (1.0023 g) was dissolved in 30 mL of anhydrous ethanol and heated to reflux overnight. After the reaction was completed, the reaction solution was concentrated and purified by fast column chromatography to give 0.7430 g of diethyl ester of squaric acid in 50% yield. 2. The resulting diethyl (ethyl) squarate, 2-aminopyridine (100 mg, 0.588 mmol) and triethylamine (10 drops) were dissolved in dichloromethane (10 mL) and stirred at room temperature overnight. After completion of the reaction, the reaction solution was concentrated under reduced pressure and purified by fast column chromatography (petroleum ether/ethyl acetate, 2:1) to afford compound 6 as a white solid in 73% yield. 3. The NMR data of compound 6 were as follows: 1H NMR (400 MHz, acetone-d6) δ 10.26 (s, 1H), 8.50-8.29 (m, 1H), 7.98-7.78 (m, 1H), 7.68 (d, J = 8.3 Hz, 1H), 7.14 (dd, J = 6.9, 5.3 Hz, 1H), 4.85 (q, J = 7.1 Hz, 2H), 1.48 (t, J = 7.1 Hz, 3H); 13C NMR (100 MHz, acetone-d6) δ 186.42, 180.83, 170.33, 166.86, 152.22, 149.33, 139.43, 120.17, 113.63, 70.65, 16.06.

References

[1] Journal of Materials Chemistry A, 2015, vol. 3, # 6, p. 2883 - 2894
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 22, p. 6181 - 6186
[3] Angew. Chem., 2017, vol. 129, # 22, p. 6277 - 6282,6
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 2, p. 263 - 272
[5] Chemical Communications, 2013, vol. 49, # 89, p. 10465 - 10467

Diethyl squarate synthesis

Synthesis of Diethyl squarate from Triethyl orthoformate and Squaric acid

Diethyl squarate Preparation Products And Raw materials

Raw materials

Ethanol Squaric acid

Preparation Products

3,4-Dimethoxy-3-cyclobutene-1,2-dione 3-(BENZYLAMINO)-4-ETHOXYCYCLOBUT-3-ENE-1,2-DIONE 3-Cyclobutene-1,2-dione,3-amino-4-ethoxy-(9CI) 3-[(2-ETHOXY-3,4-DIOXO-1-CYCLOBUTEN-1-YL)AMINO]-2-HYDROXY-N,N-DIMETHYL-BENZAMIDE

Diethyl squarate Suppliers

Global( 245)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
career henan chemical co	58
HaBo Hong Kong Co., Limited.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from Diethyl squarate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	Diethyl squarate 5231-87-8	US $2.00-5.00 / KG	0.1KG	99%	g-kg-tons	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-06-27	Diethyl squarate 5231-87-8	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	Diethyl squarate 5231-87-8	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

Diethyl squarate
5231-87-8
US $2.00-5.00 / KG
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Diethyl squarate
5231-87-8
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Diethyl squarate
5231-87-8
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

Diethyl squarate Spectrum

Diethyl squarate(5231-87-8)MS Diethyl squarate(5231-87-8)¹HNMR Diethyl squarate(5231-87-8)¹³CNMR Diethyl squarate(5231-87-8)IR1

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3,4-DIETHOXYCYCLOBUTANE-1,2-DIONE Diethyl squarate, Squaric acid diethyl ester SQUARIC ACID DIETHYL ESTER,(DIETHYL SQUARATE, 3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE) DIETHOXYCYCLOBUTENEDIONE 3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE 98% SQUARICACIDDIETHYLESTER/3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE 3,4-Diethoxy-3-cyclobuten-1,2-dion Diethyl quadratate 3,4-Diethoxy-3-Cyclobutene-1,2-Dione Diethyl Squarate 3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE, 98 % DiethylSquarate98% Diethyl squarate, 1,2-Diethoxy-3,4-dioxocyclobut-1-ene Diethyl Suquarate Suquaric Acid Diethyl Ester 3,4-Diethoxy-3-cyclobuten-1,2-dione Diethylsquarate[3,4-Diethoxy-3-cyclobutene-1,2-dione] DIETHYL SQUARATE DIETHYL SUQUARATE 3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE 3,4-DIETHOXYCYCLOBUT-3-ENE-1,2-DIONE 1,2-DIETHOXYCYCLOBUTENEDIONE SQUARIC ACID DIETHYL ESTER SUQUARIC ACID DIETHYL ESTER TIMTEC-BB SBB008498 3-Cyclobutene-1,2-dione, 3,4-diethoxy- SQUARIC ACID DIETHYL ESTER,(DIETHYL SQUARATE, 3,4-DIETHOXY-3-CYCLO SQUARIC ACID DIETHYL ESTER,(DIETHYL SQUARATE, 3,4-DIETHOXY- Diethyl squarate in stock Factory 3,4-Diethoxycyclobut-3-ene-1,2-dione 98% diethoxycyclobut-3-ene-1,2-dione 3,4-Diethoxy-3-cyclobutene-1,2-dione> 3,4-DiethoxycycL obut-3-ene-1,2-dione TIANFU-CHEM CAS:5231-87-8 Diethyl squarate 5231-87-8 C2H5O2C4O2 Simple 4-Membered Ring Compounds C7 to C8 Carbonyl Compounds Building Blocks Cyclobutanes & Cyclobutenes Organic Building Blocks Ketones Cyclobutanes & Cyclobutenes Simple 4-Membered Ring Compounds Ring Systems Aluminium foil bag/Fluoride bottle or on your request