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ChemicalBook >> CAS DataBase List >>1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]-

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]-

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- Structure
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- structure
CAS No.
2687970-96-1
Chemical Name:
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]-
Synonyms
TDI-011536;(Z)-N-(3-Benzyl-4-(hydroxymethyl)thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]-
CBNumber:
CB110980346
Molecular Formula:
C19H16N4O2S
Molecular Weight:
364.42
MDL Number:
MOL File:
2687970-96-1.mol
Last updated:2025-10-09 14:55:14
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1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- Properties

Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 12.30±0.40(Predicted)
form Solid
color White to off-white
InChI InChI=1S/C19H16N4O2S/c24-11-14-12-26-19(23(14)10-13-5-2-1-3-6-13)22-18(25)16-9-21-17-15(16)7-4-8-20-17/h1-9,12,24H,10-11H2,(H,20,21)/b22-19-
InChIKey LJNPGPUDPDQGLE-QOCHGBHMSA-N
SMILES C(C1C=CC=CC=1)N1C(=CS/C/1=N\C(C1=CNC2=NC=CC=C12)=O)CO

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- Chemical Properties,Uses,Production

Description

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1].

TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of MÜller glia in human retinal organoids[1].

Cell Proliferation Assay[1]

TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1].
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1].

Uses

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1].

in vivo

TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1].
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1].

Animal Model:Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)[1].
Dosage:200 mg/kg
Administration:Intraperitoneal injections; once.
Result:Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.
Animal Model:Male 8-week-old mice (cryolesion model)[1].
Dosage:100 mg/kg
Administration:Intraperitoneal injections; once daily for 2 or 3 days.
Result:Promoted cardiomyocytes proliferation.

References

[1] Kastan NR, et al. Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2206113119. DOI:10.1073/pnas.2206113119

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- Suppliers

Global( 23)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32434 58
Shandong Jirun Biomedical Technology Co., Ltd. 0539-0539-8613587 17661611089 2639273505@qq.com China 202 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4667 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6771 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 7992 62
Shandong Chenxi Pharmaceutical Co., Ltd. +86-0531-88803416 13153166250 sales@chemedpharma.com China 203 58
DC Chemicals 021-8447131 13564518121 doncunbiosci@gmail.com China 545 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 63313187 15358055255 63313187@qq.com China 1989 58
Hubei wei shi reagent group ltd., company 027-59102966 18717199209 2853877583@qq.com China 2553 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shandong Jirun Biomedical Technology Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shandong Chenxi Pharmaceutical Co., Ltd. 58
DC Chemicals 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 58
Hubei wei shi reagent group ltd., company 58

View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TDI-011536 pictures 2025-10-09 TDI-011536
2687970-96-1
 US $51.00-172.00 / mg 99.53% 10g TargetMol Chemicals Inc.
  • TDI-011536 pictures
  • TDI-011536
    2687970-96-1
  • US $51.00-172.00 / mg
  • 99.53%
  • TargetMol Chemicals Inc.
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- TDI-011536 (Z)-N-(3-Benzyl-4-(hydroxymethyl)thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide 2687970-96-1