Ilomastat
- CAS No.
- 142880-36-2
- Chemical Name:
- Ilomastat
- Synonyms
- CS-1405;SANTACRUZ;llomastat;sc-203979A;IlloMastat;galardin tm;Ilomastat, >=98%;GM 6001 Ilomastat;Ilomastat (GM 6001);Galardin CS 610
- CBNumber:
- CB11178927
- Molecular Formula:
- C20H28N4O4
- Molecular Weight:
- 388.46
- MDL Number:
- MFCD00917040
- MOL File:
- 142880-36-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| GM 6001 | 364205 | 1mg | $124 |
| GM 6001 | 364205 | 5mg | $466 |
| Ilomastat | I1202 | 10MG | $107 |
| GM 6001 ≥90% | 14533 | 500μg | $36 |
| GM 6001 ≥90% | 14533 | 1mg | $68 |
| More product size | |||
| Density | 1.228±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO, and 100% ethanol. |
| pka | 9.16±0.20(Predicted) |
| form | Off-white solid |
| color | White |
| Sensitive | Moisture Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Cosmetics Ingredients Functions |
CHELATING SKIN CONDITIONING |
| InChIKey | NITYDPDXAAFEIT-DYVFJYSZSA-N |
| SMILES | CNC([C@@H](NC([C@@H](C(C)C)CC(NC)=O)=O)CC1=CNC2=CC=CC=C21)=O |
| FDA UNII | I0403ML141 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
Ilomastat price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 364205 | GM 6001 | 142880-36-2 | 1mg | $124 | 2026-04-30 | Buy |
| Sigma-Aldrich | 364205 | GM 6001 | 142880-36-2 | 5mg | $466 | 2026-04-30 | Buy |
| TCI Chemical | I1202 | Ilomastat | 142880-36-2 | 10MG | $107 | 2026-04-30 | Buy |
| Cayman Chemical | 14533 | GM 6001 ≥90% | 142880-36-2 | 500μg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 14533 | GM 6001 ≥90% | 142880-36-2 | 1mg | $68 | 2026-04-30 | Buy |
Ilomastat Chemical Properties,Uses,Production
Description
Ilomastat (142880-36-2) is a potent pan-specific inhibitor of matrix metalloproteinases (MMPs).1 Ki values have been reported for the following human MMPs: MMP-1, 0.4nM; MMP-2, 0.5nM; MMP-3, 27nM; MMP-7, 3.7nM; MMP-8, 0.1nM; MMP-9, 0.2nM; MMP-12, 3.6nM; MMP-14, 13.4nM; MMP-26, 0.36nM.2-4 Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE and ADAM19.
Uses
GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs). It inhibits zinc-containing thermolysin and elastase from P. aeruginosa, both with Ki values of 20 nM. GM 6001 inhibits MMP-1, -2, -7, -8, -9, -12, -13, -14, -16, and -26 with Ki or IC50 values between 0.1 and 10 nM. It inhibits disintegrin and metalloproteinase domain-containing (ADAM) proteins ADAM9, ADAM10, ADAM12, and ADAM17 at nanomolar concentrations. It less potently inhibits lethal factor from B. anthracis anthrax lethal toxin (Ki = 2.74 μM). GM 6001 also impairs the growth of the human pathogen Chlamydia by inhibiting peptide deformylase, which contains iron rather than zinc (IC50 = 38 nM).
Uses
Ilomastat is a metalloprotease inhibitor.
Definition
ChEBI: Ilomastat is an N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor It has a role as an EC 3.4.24.24 (gelatinase A) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an antibacterial agent and an antineoplastic agent. It is a L-tryptophan derivative, a hydroxamic acid and a N-acyl-amino acid.
General Description
A cell-permeable, potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.
Biochem/physiol Actions
GM6001 promotes cardiovascular and hepatocellular function.
storage
Store at -20°C
References
[1] ALAN SAGHATELIAN. Activity-based probes for the proteomic profiling of metalloproteases.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 27: 10000-10005. DOI:10.1073/pnas.0402784101
[2] RICHARD E. GALARDY. Low Molecular Weight Inhibitors in Corneal Ulcerationa[J]. Annals of the New York Academy of Sciences, 1994, 732 1: 315-323. DOI:10.1111/j.1749-6632.1994.tb24746.x
[3] MINORU YAMAMOTO. Inhibition of Membrane-Type 1 Matrix Metalloproteinase by Hydroxamate Inhibitors: An Examination of the Subsite Pocket[J]. Journal of Medicinal Chemistry, 1998, 41 8: 1209-1217. DOI:10.1021/jm970404a
[4] HYUN I PARK. The intermediate S1’ pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling.[J]. The Journal of Biological Chemistry, 2003, 278 51: 51646-51653. DOI:10.1074/jbc.m310109200
Ilomastat Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
