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Nemorubicin

Nemorubicin structure

CAS No.: 108852-90-0

Chemical Name:: Nemorubicin

Synonyms: MMRDX;DMM Dox;FCE 23762;PNU 152243;Nemorubicin;PNU-152243A;Nemorubicina;NeMorubincine;-Dichlorobenzophenone;Nemorubicin (PNU 152243)

CBNumber:: CB11179292

Molecular Formula:: C32H37NO13

Molecular Weight:: 643.64

MDL Number:: MFCD00871079

MOL File:: 108852-90-0.mol

Last updated:2025-04-17 18:22:24

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Nemorubicin Properties

Boiling point	852.2±65.0 °C(Predicted)
Density	1.55±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:60.0(Max Conc. mg/mL);101.0(Max Conc. mM)
form	Powder
pka	7.35±0.60(Predicted)
color	Orange to reddish brown
FDA UNII	7618O47BQM

Nemorubicin price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	N389838	Nemorubicin	108852-90-0	1mg	$615	2021-12-16	Buy
American Custom Chemicals Corporation	API0024400	NEMORUBICIN 95.00%	108852-90-0	1MG	$930.3	2021-12-16	Buy
Crysdot	CD31004619	Nemorubicin 98+%	108852-90-0	10mg	$977	2021-12-16	Buy
Crysdot	CD31004619	Nemorubicin 98+%	108852-90-0	5mg	$638	2021-12-16	Buy

Product number	Packaging	Price	Buy
N389838	1mg	$615	Buy
API0024400	1MG	$930.3	Buy
CD31004619	10mg	$977	Buy
CD31004619	5mg	$638	Buy

Nemorubicin Chemical Properties,Uses,Production

Uses

Nemorubicin is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway, where current therapies fail. Nemorubicin is biotransformed in the liver into cytotoxic metabolites that may further contribute to render this drug highly active against primary liver tumors or liver metastases.

Definition

ChEBI: Nemorubicin is a member of morpholines, an anthracycline antibiotic, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It is functionally related to a doxorubicin.

in vivo

Nemorubicin is converted to PNU-159682 by human liver cytochrome P450 (CYP) 3A4 in rat, mouse, and dog liver microsomes^[2]. Nemorubicin (60 μg/kg) induces sifnificant tumor growth delay in scid mice bearing 9L/3A4 tumors, but shows no obvious effect on the tumor growth delay of 9L tumors in mice by i.v. or intratumoral injection (i.t.). Nemorubicin (40 μg/kg, i.p.) exhibits no antitumor activity and no host toxicity in mice bearing 9L/3A4 tumors^[4].

target

cancer

Nemorubicin Preparation Products And Raw materials

Raw materials

Preparation Products

Nemorubicin Suppliers

Global( 88)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Benoy Chemical Co., Ltd	+8617342059697	sales@benoychem.com	China	315	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Jurong Coupling Biotechnology Co., Ltd.	13656108824	coupling278191416@hotmail.com	CHINA	184	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29807	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32268	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9304	58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	+86-029-86333380 +86-18829239519	sales06@tgybio.com	China	898	58
Wuhan Golt Biotech Co., Ltd.	+8615389281203	maria@goltbiotech.com	China	970	58

Supplier	Advantage
Hangzhou Benoy Chemical Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
BOC Sciences	58
Jurong Coupling Biotechnology Co., Ltd.	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Baoji Guokang Bio-Technology Co., Ltd.	58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	58
Wuhan Golt Biotech Co., Ltd.	58

Unlocking the Potential of Nemorubicin: Insights into Its Mechanism, Applications, and Storage
Nemorubicin, a doxorubicin derivative, is a DNA-intercalator, topoisomerase and RNA synthesis inhibitor that used for the trea....
Dec 13，2024

Nemorubicin:Metabolism and Pharmacokinetics, Cytotoxic Activity And Toxicity Studies
Nemorubicin is a member of the structural group of morpholinyl anthracyclines whose lead compounds were originally obtained by....
Feb 21，2023

View Lastest Price from Nemorubicin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Nemorubicin 108852-90-0	US $51.00-197.00 / mg		97.79%	10g	TargetMol Chemicals Inc.
2021-07-13	Nemorubicin 108852-90-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	Nemorubicin 108852-90-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Nemorubicin
108852-90-0
US $51.00-197.00 / mg
97.79%
TargetMol Chemicals Inc.

Nemorubicin
108852-90-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Nemorubicin
108852-90-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

108852-90-0(Nemorubicin)Related Search:

1,8-Dihydroxyanthraquinone Adriamycin Doxorubicinone Nemorubicin Idarubicin

Chrysophanic acid 2-Ethylanthraquinone DIETHANOL PROPANOLAMINE N,N-BIS(2-HYDROXYETHYL)ISOPROPANOLAMINE 1,5-DIHYDROXYANTHRAQUINONE

2,4-DIMETHYL-2'-METHOXYBENZOPHENONE 2,4-DIMETHYL-3'-METHOXYBENZOPHENONE 2,5-DIMETHYL-3'-METHOXYBENZOPHENONE N-ETHYL-TETRAHYDRO-2H-PYRAN-4-AMINE 14-Hydroxy Carminomycin

2-METHOXY-3'-METHYLBENZOPHENONE ISLANDICIN Feudomycin A

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Nemorubicin 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-2,3,6-trideoxy-3-(2S)-2-methoxy-4-morpholinyl-.alpha.-L-lyxo-hexopyranosyloxy-, (8S,10S)- methoxy-morpholynil-doxorubicin NeMorubincine PNU152243A; PNU-152243A; PNU 152243A; NEMORUBICIN; METHOXYMORPHOLINYL-DOXORUBICIN (1S,3S)-3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 2,3,6-trideoxy-3-[(S)-2-methoxymorpholino]-alpha-L-lyxo-hexopyranoside DMM Dox FCE 23762 Methoxymorpholinyldoxorubicin MMRDX (1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranoside PNU 152243 PNU-152243A Nemorubicin (PNU 152243) 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)- 5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-a-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)- FCE 23762,FCE-23762,PNU-152243,PNU152243,inhibit,Methoxymorpholinyl doxorubicin,Inhibitor,Nemorubicin,FCE23762 Nemorubicina -Dichlorobenzophenone (8S,10S)-6,8,11-Trihydroxy-10-(((2R,4S,5S,6S)-5-hydroxy-4-((S)-2-methoxymorpholino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione 108852-90-0 108852-90-1 ≧99%