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ChemicalBook >> CAS DataBase List >>1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Structure
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one structure
CAS No.
6969-71-7
Chemical Name:
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
Synonyms
2H-[1,2,4]triazolo[4,3-a]pyridin-3-one;1,2,4-TRIAZOLO-[4,3-A]PYRIDINE-3(2H)-ONE;NSC 68462;Pyridotriazolone;Pyridyltriazolone;Pyridinotriazolone;Triazolo Pyridinone;Pyridine Triazolone;1,2,4-Triazolo[4,3-a;Pyridine triadiMefon
CBNumber:
CB1120921
Molecular Formula:
C6H5N3O
Molecular Weight:
135.12
MDL Number:
MFCD00022632
MOL File:
6969-71-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:05:02
Product description Number Pack Size Price
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one 97% 736821 25g $62.9
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one >98.0%(HPLC)(T) T1667 25g $39
Triazolopyridinone ≥98% 34393 25g $69
Triazolopyridinone ≥98% 34393 50g $127
Triazolopyridinone ≥98% 34393 100g $238
More product size
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1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Properties

Melting point 231°C
Density 1.51±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka 7.86±0.20(Predicted)
form Solid
color Light Brown to Brown
BRN 607433
Stability Light Sensitive
InChI InChI=1S/C6H5N3O/c10-6-8-7-5-3-1-2-4-9(5)6/h1-4H,(H,8,10)
InChIKey LJRXNXBFJXXRNQ-UHFFFAOYSA-N
SMILES C12=NNC(=O)N1C=CC=C2
LogP 0.113
CAS DataBase Reference 6969-71-7(CAS DataBase Reference)
FDA UNII J5EWP6L1VA
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
2 0

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 736821 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one 97% 6969-71-7 25g $62.9 2022-05-15 Buy
TCI Chemical T1667 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one >98.0%(HPLC)(T) 6969-71-7 25g $39 2026-04-30 Buy
Cayman Chemical 34393 Triazolopyridinone ≥98% 6969-71-7 25g $69 2026-04-30 Buy
Cayman Chemical 34393 Triazolopyridinone ≥98% 6969-71-7 50g $127 2026-04-30 Buy
Cayman Chemical 34393 Triazolopyridinone ≥98% 6969-71-7 100g $238 2026-04-30 Buy
Product number Packaging Price Buy
736821 25g $62.9 Buy
T1667 25g $39 Buy
34393 25g $69 Buy
34393 50g $127 Buy
34393 100g $238 Buy

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Chemical Properties,Uses,Production

Chemical Properties

Beige Solid

Uses

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one was used to prepare a congener of Trazodone (T718500) which was found to be a potent and selective inhibitor of synaptosomal uptake of 5-hydroxytryptamine.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 28, p. 1394, 1985 DOI: 10.1021/jm00148a004

Synthesis

2-Chloropyridine

109-09-1

Semicarbazide hydrochloride

563-41-7

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

6969-71-7

General procedure for the synthesis of [1,2,4]triazolo[4,3-a]pyridin-3-(2H)-one from 2-chloropyridine and aminourea hydrochloride: 2-chloropyridine (5.0 g, 44.03 mmol), aminourea hydrochloride (9.8 g, 88.06 mmol), and 2-ethoxyethanol (15 mL) were mixed and heated to reflux. Concentrated hydrochloric acid (0.1 mL dissolved in 1 mL of 2-ethoxyethanol) was slowly added to the reaction mixture. The reaction was kept at reflux for 24 hours and subsequently cooled to about 60 °C and diluted with deionized water (15 mL). The resulting light yellow solid product was collected by filtration and washed with deionized water to afford the title compound (2.2 g, 51% yield). The melting point of the product was 235-240°C. 1H NMR (300 MHz, DMSO-d6) δ 6.51-6.60 (m, 1H), 7.05-7.22 (m, 2H), 7.80 (d, J=7.1 Hz, 1H), 12.45 (br, 1H, exchangeable with D2O); IR (KBr) ν 3173, 3098. 3048, 1717, 1634, 1536, 1348 cm-1; MS 136 (M+1).

References

[1] Patent: US2009/209550, 2009, A1. Location in patent: Page/Page column 25-26
[2] Patent: US4254124, 1981, A

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one synthesis

4930-98-7
57-13-6
6969-71-7
Synthesis of 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one from 2-Hydrazinopyridine and Urea

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Preparation Products And Raw materials

Raw materials

Pyridine Semicarbazide hydrochloride 2-Bromopyridine Sulfuric acid 2-Ethoxyethanol
Urea 2-Chloropyridine 2-Hydrazinopyridine

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Preparation Products

Diethylacetamide Acetic acid 2-(2-hydroxyethyl)-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Suppliers

Global( 371)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21588 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2950 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8828 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 8742 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Jinan Finer Chemical Co., Ltd 		58
Standardpharm Co. Ltd. 		58
Alchem Pharmtech,Inc. 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shanghai UCHEM Inc. 		58

View Lastest Price from 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one pictures 2025-11-18 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
6969-71-7
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one pictures 2021-08-12 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
6969-71-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one pictures 2019-07-06 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
6969-71-7
 $8.00 1kg 99% 10MT Career Henan Chemical Co

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Spectrum

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one(6969-71-7)MS1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one(6969-71-7)1HNMR1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one(6969-71-7)13CNMR1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one(6969-71-7)IR11,2,4-Triazolo[4,3-a]pyridin-3(2H)-one(6969-71-7)IR2

6969-71-7(1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one)Related Search:

Sulfasalazine Furazolidone Sodium Pyrithione Chromium picolinate Triadimefon
Zinc pyrithione Trazodone 4-Methylpyridine Pyridine 2-Pyridinecarboxaldehyde
Pyridine hydrochloride Pyridine sulfur trioxide Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 6-BROMO-1,2,4-TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE Trazodone hydrochloride
4-HYDROXYPYRIDINE 2-(3-CHLOROPROPYL)-1,2,4-TRIAZOL-[4,3-A]PYRIDINE-3 (2H)-ONE 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl-d6]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one Hydrochloride

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1,2,4-TRIAZOLE(4,3)PYRIDIN-3-(2H)-ONE 1,2,4-TRIAZOL-(4,3-A)-PYRIDINE 3 (2H)-ONE 1,2,4-Triazolopyridin-3-one 3-HYDROXYTRIAZOLO[4,3-A]PYRIDINE 3-HYDROXY-1,2,4-TRIAZOLO[4,3-A]PYRIDINE 1,2,4-Triazole-(4,3-alpha)pyri Trazodone Impurity 15 2,4-Triazolopyridin-3-one Triazolo Pyridinone 1,2,4-Triazole-(4,3-a) Pyridine-3 (2H) - One 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 98+% 1,2,4-Triazolo4,3-aüpyridin-3(2H)-one, 98+% 1,2,4-TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE 1,2,4-Triazolo[4,3-a Pyridine triadiMefon 1,2,4-trizolo(4,3a)pyridine-3(2H)-one 1,2,4-Triazol-[4,3-a]-pyridin-3(2H)-one 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one 97% 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one NSC 68462 s-Triazolo[4,3-a]pyridin-3-ol 1,2,4-Triazolo[4,3-a]pyridin-3(H)-one 2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one Pyridine threeTriadiMefon 1,2,4-Triazolo[4,3-a]pyridine-3(2H) Trazodone Triazolopyridinone 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one ISO 9001：2015 REACH [1,2,4] TRIAZOLO [4,3-A] PYRIDIN-3(2H)-ONE ( TPO ) 1,2,4-TRIAZOLO-[4,3-α]-PYRIDIN-3(2H)-ONE 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one (9CI, ACI) 1,2,4 triazolo[4,3-a pyridine-3(2H)-Onesodium (TDI) 1,2,4]triazolo[4,3-a]pyridine-3(2H)-Onesodium Pyridinotriazolone 1,2,4]triazolo[4,3-a]pyridin-3-one Pyridotriazolone Pyridine Triazolone (trazodone impurity 4) Pyridyltriazolone Trazodone EP Impurity K (Triazolopyridinone) Trazodone Hydrochloride Impurity 15 (Trazodone Hydrochloride EP Impurity K) Trazodone impurity K Trazodone Impurity 15 (Trazodone Hydrochloride EP Impurity K) Pyridine Triazolone 1,2,4-TRIAZOLO-[4,3-A]PYRIDINE-3(2H)-ONE 2H-[1,2,4]triazolo[4,3-a]pyridin-3-one 6969-71-7 6967-71-7 C6H5N3O Heterocycles intermediate for some organic synthesis Fused Ring Systems Pyridines APIs & Intermediate Pyrimidine