1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro-
- CAS No.
- 72583-92-7
- Chemical Name:
- 1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro-
- Synonyms
- RX 801077;2-(2-benzofuranyl)-2-imidazoline;1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro-
- CBNumber:
- CB11239183
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- 72583-92-7.mol
1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro- Chemical Properties,Uses,Production
Uses
RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI)[1][2].
Definition
ChEBI: 2-(2-benzofuranyl)-4,5-dihydro-1H-imidazole is a member of benzofurans.
in vivo
RX 801077 (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2].
| Animal Model: | 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2] |
| Dosage: | 5, 10, 20 mg/kg |
| Administration: | I.p.; twice daily for 3 days |
| Result: | Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex. |
References
[1] Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272(2):681-8. PMID:7853182
[2] Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.
1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19962 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6967 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-58851090 17714375163 | 2881759498@qq.com | China | 13011 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 55 |
| TargetMol Chemicals Inc. | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 58 |
