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ChemicalBook >> CAS DataBase List >>Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)-

Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)-

Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)- Structure
Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)- structure
CAS No.
2166378-92-1
Chemical Name:
Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)-
Synonyms
Glucocorticoid receptor agonist-2;Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)-
CBNumber:
CB112442196
Molecular Formula:
C34H35F2NO7
Molecular Weight:
607.64
MDL Number:
MOL File:
2166378-92-1.mol
Last updated:2025-04-17 18:22:24
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Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)- Properties

Boiling point 762.0±60.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
pka 12.74±0.70(Predicted)
form Solid
color White to off-white

Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)- Chemical Properties,Uses,Production

Uses

Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373[1].

References

[1] Mcpherson MJ, et al. Preparation of glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471. 2017.

Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)- Preparation Products And Raw materials

Raw materials

Preparation Products

Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Supplier Advantage
Aladdin Scientific 		58
Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-(3-aminophenoxy)phenyl]methylene]bis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)- Glucocorticoid receptor agonist-2 2166378-92-1 C34H35F2NO7